Horizontal versus familial transmission of Helicobacter pylori (2008)
Schwarz, Sandra, Morelli, Giovanna, Manica, Andrea, Balloux, Francois, Owen, Robert J., Graham, David Y., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Horizontal versus familial transmission of Helicobacter pylori (2008)
Schwarz, Sandra, Morelli, Giovanna, Manica, Andrea, Balloux, Francois, Owen, Robert J., Graham, David Y., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Horizontal versus Familial Transmission of Helicobacter pylori (2008)
Schwarz, Sandra, Morelli, Giovanna, Kusecek, Barica, Manica, Andrea, Balloux, Francois, Owen, Robert J., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Medizinische Mikrobiologie und Infektiologie, 6th Edition. (2008)
Hahn, Helmut, Kaufmann, Stefan H. E., Schulz, Thomas F., Suerbaum, Sebastian
Chaberny, Iris F., Schwab, Frank, Ziesing, Stefan, Suerbaum, Sebastian, Gastmeier, Petra
Objectives To determine whether a routine admission screening in surgical wards and intensive care units (ICUs) was effective in reducing methicillin-resistant Staphylococcus aureus (MRSA)...
An African origin for the intimate association between humans and Helicobacter pylori (2007)
Linz, Bodo, Balloux, Francois, Moodley, Yoshan, Manica, Andrea, Liu, Hua, Roumagnac, Philippe, ...
Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic...
An African origin for the intimate association between humans and Helicobacter pylori (2007)
Linz, Bodo, Balloux, Francois, Moodley, Yoshan, Manica, Andrea, Liu, Hua, Roumagnac, Philippe, ...
Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic...
Andrzejewska, Joanna, Lee, Sae Kyun, Olbermann, Patrick, Lotzing, Nina, Katzowitsch, Elena, Linz, Bodo, ...
An African origin for the intimate association between humans and Helicobacter pylori (2007)
Linz, Bodo, Balloux, François, Moodley, Yoshan, Manica, Andrea, Liu, Hua, Roumagnac, Philippe, ...
Andrzejewska, Joanna, Lee, Sae Kyung, Olbermann, Patrick, Lotzing, Nina, Katzowitsch, Elena, Linz, Bodo, ...
Olbermann, Patrick, Linz, Bodo, Andrzejewska, Joanna, Lotzing, Nina, Achtman, Mark, Suerbaum, Sebastian, ...
Ukena, Sya N, Westendorf, Astrid M, Hansen, Wiebke, Rohde, Manfred, Geffers, Robert, Coldewey, Sina, ...
Abstract Background The use of live microorganisms to influence positively the course of intestinal disorders such as infectious diarrhea or chronic inflammatory conditions has recently gained...
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori (2005)
Helga Gressmann, Bodo Linz, Rohit Ghai, Klaus-Peter Pleissner, Ralph Schlapbach, Yoshio Yamaoka, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Gain and loss of multiple genes during the evolution of Helicobacter pylori (2005)
Gressmann, Helga, Linz, Bodo, Ghai, Rohit, Pleissner, Klaus-Peter, Schlapbach, Ralph, Yamaoka, Yoshio, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Helicobacter pylori: recombination, population structure and human migrations (2004)
Suerbaum,Sebastian, Achtman,Mark
Helicobacter pylori shows extensive genetic diversity and variability due to frequent intraspecific recombination during mixed infection. In the last years, modern genetic and genomic technology as...
Niehus,Eike, Gressmann,Helga, Ye,Fang, Schlapbach,Ralph, Dehio,Michaela, Dehio,Christoph, ...
The flagellar system of Helicobacter pylori, which comprises more than 40 mostly unclustered genes, is essential for colonization of the human stomach mucosa. In order to elucidate the complex...
Salaun,Laurence, Linz,Bodo, Suerbaum,Sebastian, Saunders,Nigel J.
Phase variation is a common mechanism used by pathogenic bacteria to generate intra-strain diversity that is important in niche adaptation and is strongly associated with virulence determinants....
Traces of human migrations in Helicobacter pylori populations (2003)
Falush,Daniel, Wirth,Thierry, Linz,Bodo, Pritchard,Jonathan K., Stephens,Matthew, Kidd,Mark, ...
Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations derive...
Traces of human migrations in Helicobacter pylori populations (2003)
Falush, Daniel, Wirth, Thierry, Linz, Bodo, Pritchard, Jonathan K., Stephens, Matthew, Kidd, Mark, ...
Falush,Daniel, Kraft,Christian, Taylor,Nancy S., Correa,Pelayo, Fox,James G., Achtman,Mark, ...
The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of...
Falush, Daniel, Kraft, Christian, Taylor, Nancy S., Correa, Pelayo, Fox, James G., Achtman, Mark, ...
Bochum, Univ,. Habil.-Schr., 1995.
Bochum, Univ., Diss., 1988.
Free recombination within Helicobacter pylori
Suerbaum, Sebastian, Smith, John Maynard, Bapumia, Khairun, Morelli, Giovanna, Smith, Noel H., Kunstmann, Erdmute, ...
Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and for linkage...
Falush, Daniel, Kraft, Christian, Taylor, Nancy S., Correa, Pelayo, Fox, James G., Achtman, Mark, ...
The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of...
Genetic Diversity of Neisseria lactamica Strains from Epidemiologically Defined Carriers
Alber, Dirk, Oberkötter, Mark, Suerbaum, Sebastian, Claus, Heike, Frosch, Matthias, Vogel, Ulrich
We assessed the genetic diversity of 26 Neisseria lactamica strains from epidemiologically related sources, i.e., groups of kindergartens and primary schools in three Bavarian towns, by the partial...
Allelic Diversity and Recombination in Campylobacter jejuni
Suerbaum, Sebastian, Lohrengel, Marc, Sonnevend, Agnes, Ruberg, Florian, Kist, Manfred
The allelic diversity and population structure of Campylobacter jejuni were studied by multilocus nucleotide sequence analysis. Sequences from seven housekeeping genes were obtained from 32 C. jejuni...
Schreiber, Sören, Stüben, Manuela, Josenhans, Christine, Scheid, Peter, Suerbaum, Sebastian
We describe a method that permits the collection of very small samples (2 nl) from precisely defined positions within the gastric mucus of anesthetized mice. This method was used to study the in vivo...
The Nonfunctional Allele TCRBV6S1B Is Strongly Associated with Helicobacter pylori Infection
Kunstmann, Erdmute, Hardt, Cornelia, Elitok, Ercan, Harder, Marianne, Suerbaum, Sebastian, Peitz, Ulrich, ...
To determine genetic susceptibility factors for Helicobacter pylori infection, polymorphic T-cell receptor gene elements were investigated in 203 H. pylori-infected individuals and 180 uninfected...
Josenhans, Christine, Eaton, Kathryn A., Thevenot, Tracy, Suerbaum, Sebastian
The genome of Helicobacter pylori contains numerous simple nucleotide repeats that have been proposed to have regulatory functions and to compensate for the conspicuous dearth of master regulatory...
Clyne, Marguerite, Ocroinin, Tadhg, Suerbaum, Sebastian, Josenhans, Christine, Drumm, Brendan
Isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae were screened for their ability to adhere to primary human and ferret gastric epithelial cells, respectively. We...
The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
Suerbaum, Sebastian, Josenhans, Christine, Sterzenbach, Torsten, Drescher, Bernd, Brandt, Petra, Bell, Monica, ...
Helicobacter hepaticus causes chronic hepatitis and liver cancer in mice. It is the prototype enterohepatic Helicobacter species and a close relative of Helicobacter pylori, also a recognized...
Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
Kullberg, Marika C., Andersen, John F., Gorelick, Peter L., Caspar, Patricia, Suerbaum, Sebastian, Fox, James G., ...
It is now well established that the intestinal flora plays an important role in the pathogenesis of inflammatory bowel disease (IBD). However, whether bacteria serve as the sole target of the immune...
The spatial orientation of Helicobacter pylori in the gastric mucus
Schreiber, Sören, Konradt, Manuela, Groll, Claudia, Scheid, Peter, Hanauer, Guido, Werling, Hans-Otto, ...
The highly motile human pathogen Helicobacter pylori lives deep in the gastric mucus layer. To identify which chemical gradient guides the bacteria within the mucus layer, combinations of luminal...
Schmausser, Bernd, Josenhans, Christine, Endrich, Simon, Suerbaum, Sebastian, Sitaru, Cassian, Andrulis, Mindaugas, ...
In Helicobacter pylori gastritis, neutrophil activation and migration, which play central roles in the pathogenesis of the disease, are regulated by the neutrophil attractant chemokines interleukin 8...
Rapid Loss of Motility of Helicobacter pylori in the Gastric Lumen In Vivo
Schreiber, Sören, Bücker, Roland, Groll, Claudia, Azevedo-Vethacke, Marina, Garten, Désirée, Scheid, Peter, ...
The human pathogen Helicobacter pylori has infected more than half of the world's population. Nevertheless, the first step of infection, the acute colonization of the gastric mucus, is poorly...
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori
Gressmann, Helga, Linz, Bodo, Ghai, Rohit, Pleissner, Klaus-Peter, Schlapbach, Ralph, Yamaoka, Yoshio, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Boutin, Samuel R., Shen, Zeli, Rogers, Arlin B., Feng, Yan, Ge, Zhongming, Xu, Sandy, ...
A 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain ATCC 51449 is a putative pathogenicity island (PAI). To determine the in vivo relevance of this PAI, we inoculated A/JCr mice with one...
Genomic Changes during Chronic Helicobacter pylori Infection
Kraft, Christian, Stack, Allison, Josenhans, Christine, Niehus, Eike, Dietrich, Guido, Correa, Pelayo, ...
The gastric pathogen Helicobacter pylori shows tremendous genetic variability within human populations, both in gene content and at the sequence level. We investigated how this variability arises by...
Ukena, Sya N, Westendorf, Astrid M, Hansen, Wiebke, Rohde, Manfred, Geffers, Robert, Coldewey, Sina, ...
Andrzejewska, Joanna, Lee, Sae Kyung, Olbermann, Patrick, Lotzing, Nina, Katzowitsch, Elena, Linz, Bodo, ...
The Helicobacter pylori cag pathogenicity island (cag PAI) encodes components of a type IV secretion system (T4SS) involved in host interaction and pathogenicity. Previously, seven cag PAI proteins...
Free recombination within Helicobacter pylori
Suerbaum, Sebastian, Smith, John Maynard, Bapumia, Khairun, Morelli, Giovanna, Smith, Noel H., Kunstmann, Erdmute, ...
Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and for linkage...
Falush, Daniel, Kraft, Christian, Taylor, Nancy S., Correa, Pelayo, Fox, James G., Achtman, Mark, ...
The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of...
Genetic Diversity of Neisseria lactamica Strains from Epidemiologically Defined Carriers
Alber, Dirk, Oberkötter, Mark, Suerbaum, Sebastian, Claus, Heike, Frosch, Matthias, Vogel, Ulrich
We assessed the genetic diversity of 26 Neisseria lactamica strains from epidemiologically related sources, i.e., groups of kindergartens and primary schools in three Bavarian towns, by the partial...
Allelic Diversity and Recombination in Campylobacter jejuni
Suerbaum, Sebastian, Lohrengel, Marc, Sonnevend, Agnes, Ruberg, Florian, Kist, Manfred
The allelic diversity and population structure of Campylobacter jejuni were studied by multilocus nucleotide sequence analysis. Sequences from seven housekeeping genes were obtained from 32 C. jejuni...
Schreiber, Sören, Stüben, Manuela, Josenhans, Christine, Scheid, Peter, Suerbaum, Sebastian
We describe a method that permits the collection of very small samples (2 nl) from precisely defined positions within the gastric mucus of anesthetized mice. This method was used to study the in vivo...
The Nonfunctional Allele TCRBV6S1B Is Strongly Associated with Helicobacter pylori Infection
Kunstmann, Erdmute, Hardt, Cornelia, Elitok, Ercan, Harder, Marianne, Suerbaum, Sebastian, Peitz, Ulrich, ...
To determine genetic susceptibility factors for Helicobacter pylori infection, polymorphic T-cell receptor gene elements were investigated in 203 H. pylori-infected individuals and 180 uninfected...
Josenhans, Christine, Eaton, Kathryn A., Thevenot, Tracy, Suerbaum, Sebastian
The genome of Helicobacter pylori contains numerous simple nucleotide repeats that have been proposed to have regulatory functions and to compensate for the conspicuous dearth of master regulatory...
Clyne, Marguerite, Ocroinin, Tadhg, Suerbaum, Sebastian, Josenhans, Christine, Drumm, Brendan
Isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae were screened for their ability to adhere to primary human and ferret gastric epithelial cells, respectively. We...
The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
Suerbaum, Sebastian, Josenhans, Christine, Sterzenbach, Torsten, Drescher, Bernd, Brandt, Petra, Bell, Monica, ...
Helicobacter hepaticus causes chronic hepatitis and liver cancer in mice. It is the prototype enterohepatic Helicobacter species and a close relative of Helicobacter pylori, also a recognized...
Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
Kullberg, Marika C., Andersen, John F., Gorelick, Peter L., Caspar, Patricia, Suerbaum, Sebastian, Fox, James G., ...
It is now well established that the intestinal flora plays an important role in the pathogenesis of inflammatory bowel disease (IBD). However, whether bacteria serve as the sole target of the immune...
The spatial orientation of Helicobacter pylori in the gastric mucus
Schreiber, Sören, Konradt, Manuela, Groll, Claudia, Scheid, Peter, Hanauer, Guido, Werling, Hans-Otto, ...
The highly motile human pathogen Helicobacter pylori lives deep in the gastric mucus layer. To identify which chemical gradient guides the bacteria within the mucus layer, combinations of luminal...
Schmausser, Bernd, Josenhans, Christine, Endrich, Simon, Suerbaum, Sebastian, Sitaru, Cassian, Andrulis, Mindaugas, ...
In Helicobacter pylori gastritis, neutrophil activation and migration, which play central roles in the pathogenesis of the disease, are regulated by the neutrophil attractant chemokines interleukin 8...
Rapid Loss of Motility of Helicobacter pylori in the Gastric Lumen In Vivo
Schreiber, Sören, Bücker, Roland, Groll, Claudia, Azevedo-Vethacke, Marina, Garten, Désirée, Scheid, Peter, ...
The human pathogen Helicobacter pylori has infected more than half of the world's population. Nevertheless, the first step of infection, the acute colonization of the gastric mucus, is poorly...
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori
Gressmann, Helga, Linz, Bodo, Ghai, Rohit, Pleissner, Klaus-Peter, Schlapbach, Ralph, Yamaoka, Yoshio, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Boutin, Samuel R., Shen, Zeli, Rogers, Arlin B., Feng, Yan, Ge, Zhongming, Xu, Sandy, ...
A 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain ATCC 51449 is a putative pathogenicity island (PAI). To determine the in vivo relevance of this PAI, we inoculated A/JCr mice with one...
Genomic Changes during Chronic Helicobacter pylori Infection
Kraft, Christian, Stack, Allison, Josenhans, Christine, Niehus, Eike, Dietrich, Guido, Correa, Pelayo, ...
The gastric pathogen Helicobacter pylori shows tremendous genetic variability within human populations, both in gene content and at the sequence level. We investigated how this variability arises by...
Ukena, Sya N, Westendorf, Astrid M, Hansen, Wiebke, Rohde, Manfred, Geffers, Robert, Coldewey, Sina, ...
Andrzejewska, Joanna, Lee, Sae Kyung, Olbermann, Patrick, Lotzing, Nina, Katzowitsch, Elena, Linz, Bodo, ...
The Helicobacter pylori cag pathogenicity island (cag PAI) encodes components of a type IV secretion system (T4SS) involved in host interaction and pathogenicity. Previously, seven cag PAI proteins...
Sterzenbach, Torsten, Lee, Sae Kyung, Brenneke, Birgit, Von Goetz, Franz, Schauer, David B., Fox, James G., ...
Enterohepatic Helicobacter species infect the intestinal tracts and biliary trees of various mammals, including mice and humans, and are associated with chronic inflammatory diseases of the...
Probiotic Escherichia coli Nissle 1917 Inhibits Leaky Gut by Enhancing Mucosal Integrity
Ukena, Sya N., Singh, Anurag, Dringenberg, Ulrike, Engelhardt, Regina, Seidler, Ursula, Hansen, Wiebke, ...
Schweinitzer, Tobias, Mizote, Tomoko, Ishikawa, Naohiro, Dudnik, Alexey, Inatsu, Sakiko, Schreiber, Sören, ...
Helicobacter pylori requires flagellar motility and chemotaxis to establish and maintain chronic infection of the human stomach. The pH gradient in the stomach mucus is essential for bacterial...
Horizontal versus Familial Transmission of Helicobacter pylori
Schwarz, Sandra, Morelli, Giovanna, Kusecek, Barica, Manica, Andrea, Balloux, Francois, Owen, Robert J., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Kulick, Stefan, Moccia, Claudia, Didelot, Xavier, Falush, Daniel, Kraft, Christian, Suerbaum, Sebastian
Helicobacter pylori colonizes the gastric mucosa of half of the human population, causing gastritis, ulcers, and cancer. H. pylori is naturally competent for transformation by exogenous DNA, and...
Sterzenbach, Torsten, Bartonickova, Lucie, Behrens, Wiebke, Brenneke, Birgit, Schulze, Jessika, Kops, Friederike, ...
The enterohepatic Helicobacter species Helicobacter hepaticus colonizes the murine intestinal and hepatobiliary tract and is associated with chronic intestinal inflammation, gall stone formation,...