Expression of iron-related genes in human brain and brain tumors (2009)
Hänninen, Milla M, Haapasalo, Joonas, Haapasalo, Hannu, Fleming, Robert E, Britton, Robert S, Bacon, Bruce R, ...
Abstract Background Defective iron homeostasis may be involved in the development of some diseases within the central nervous system. Although the expression of genes involved in normal iron balance...
Innocenti, Alessio, Hilvo, Mika, Parkkila, Seppo, Scozzafava, Andrea, Supuran, Claudiu T.
Bioorganic & Medicinal Chemistry Letters Vol.19 Nr.13, 3430 - 3433
Parkkila, Seppo, Innocenti, Alessio, Kallio, Heini, Hilvo, Mika, Scozzafava, Andrea, Supuran, Claudiu T.
Bioorganic & Medicinal Chemistry Letters Vol.19 Nr.15, 4102 - 4106
Bootorabi, Fatemeh, Jänis, Janne, Valjakka, Jarkko, Isoniemi, Sari, Vainiotalo, Pirjo, Vullo, Daniela, ...
Abstract Background Acetaldehyde, the first metabolite of ethanol, can generate covalent modifications of proteins and cellular constituents. However, functional consequences of such modification...
The calcium-binding protein S100P in normal and malignant human tissues (2008)
Parkkila, Seppo, Pan, Pei-wen, Ward, Aoife, Gibadulinova, Adriana, Oveckova, Ingrid, Pastorekova, Silvia, ...
Abstract Background S100P is a Ca 2+ binding protein overexpressed in a variety of cancers, and thus, has been considered a potential tumor biomarker. Very little has been studied about its normal...
Carbonic anhydrase IX in oligodendroglial brain tumors (2008)
Järvelä, Sally, Parkkila, Seppo, Bragge, Helena, Kähkönen, Marketta, Parkkila, Anna-Kaisa, Soini, Ylermi, ...
Abstract Background Carbonic anhydrase IX is a hypoxia-induced enzyme that has many biologically important functions, including its role in cell adhesion and invasion. Methods This study was set out...
Haapasalo, Joonas, Hilvo, Mika, Nordfors, Kristiina, Haapasalo, Hannu, Parkkila, Seppo, Hyrskyluoto, Alise, ...
Carbonic anhydrase XII (CA XII) is a transmembrane enzyme that is associated with neoplastic growth. CA XII has been proposed to be involved in acidification of the extracellular milieu, creating an...
Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse (2007)
Rodriguez, Alejandra, Hilvo, Mika, Kytömäki, Leena, Fleming, Robert E, Britton, Robert S, Bacon, Bruce R, ...
Abstract Background Hereditary hemochromatosis (HH) encompasses genetic disorders of iron overload characterized by deficient expression or function of the iron-regulatory hormone hepcidin. Mutations...
Carbonic anhydrase II in the endothelium of glial tumors: A potential target for therapy (2007)
Haapasalo, Joonas, Nordfors, Kristiina, Järvelä, Sally, Bragge, Helena, Rantala, Immo, Parkkila, Anna-Kaisa, ...
Carbonic anhydrase isozyme II (CA II) is a cytosolic enzyme that is highly expressed in most organs, including the brain, where it is mainly located in the oligodendrocytes. Recent studies have shown...
A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system (2007)
Pan, Pei-wen, Rodriguez, Alejandra, Parkkila, Seppo
Abstract Background Carbonic anhydrases (CAs) are physiologically important enzymes which participate in many gastrointestinal processes such as acid and bicarbonate secretion and metabolic pathways...
Expression of carbonic anhydrases IX and XII during mouse embryonic development (2006)
Kallio, Heini, Pastorekova, Silvia, Pastorek, Jaromir, Waheed, Abdul, Sly, William S, Mannisto, Susanna, ...
Abstract Background Of the thirteen active carbonic anhydrase (CA) isozymes, CA IX and XII have been linked to carcinogenesis. It has been suggested that these membrane-bound CAs participate in...
Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa (2005)
Kummola, Laura, Hämäläinen, Jonna M, Kivelä, Jyrki, Kivelä, Antti J, Saarnio, Juha, Karttunen, Tuomo, ...
Abstract Background Carbonic anhydrase (CA) isozymes may have an important role in cancer development. Some isozymes control pH homeostasis in tumors that appears to modulate the behaviour of cancer...
Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs (2004)
Hynninen, Piritta, Hämäläinen, Jonna M, Pastorekova, Silvia, Pastorek, Jaromir, Waheed, Abdul, Sly, William S, ...
Abstract Background Carbonic anhydrase (CA) classically catalyses the reversible hydration of dissolved CO 2 to form bicarbonate ions and protons. The twelve active CA isozymes are thought to...
The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV (2002)
Parkkila, Seppo, Kivelä, Antti J, Kaunisto, Kari, Parkkila, Anna-Kaisa, Hakkola, Jukka, Rajaniemi, Hannu, ...
Abstract Background Biochemical and histochemical studies have both previously indicated plasma membrane-associated carbonic anhydrase (CA) activity in hepatocytes which has been assumed to be CA IV....
Karhumaa, Pepe, Kaunisto, Kari, Parkkila, Seppo, Waheed, Abdul, Pastoreková, Silvia, Pastorek, Jaromir, ...
Testicular fluid is concentrated and acidified during its passage through the excurrent ducts. These processes involve bicarbonate absorption, in which carbonic anhydrases are implicated. In this...
Recent advances in the pathology of alcoholic myopathy (2001)
Preedy, Victor R., Adachi, Junko, Peters, Timothy J., Worrall, Simon, Parkkila, Seppo, Niemela, Onni, ...
This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Victor R. Preedy and Junko Adachi. The presentations were (1) Alcoholic myopathy:...
Rintala, Jyrki, Jaatinen, Pia, Parkkila, Seppo, Sarviharju, Maija, Kiianmaa, Kalervo, Hervonen, Antti, ...
Acetaldehyde, the first metabolite of ethanol, has been shown to be capable of binding covalently to liver proteins in vivo, which may be responsible for a variety of toxic effects of ethanol....
The impact of Active Networks on established Network Operators. (1999)
Juhola , Arto, Marshall, Ian, Covaci, Stefan, Thomas , Velte, Donohoe, Mike, Parkkila, Seppo
A collaborative case based study has established that Active Networks will have a very significant impact on Network operators. Active Networking appears to be the only route to adding integrated...
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
Waheed, Abdul, Parkkila, Seppo, Saarnio, Juha, Fleming, Robert E., Zhou, Xiao Yan, Tomatsu, Shunji, ...
In hereditary hemochromatosis (HH), intestinal absorption of dietary iron is increased, leading to excessive iron accumulation in tissues and resultant organ damage. The HFE protein, which is...
Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro
Parkkila, Seppo, Rajaniemi, Hannu, Parkkila, Anna-Kaisa, Kivelä, Jyrki, Waheed, Abdul, Pastoreková, Silvia, ...
Acidification of the extracellular milieu of malignant tumors is reported to increase the invasive behavior of cancer cells. In normal tissues, production of acid is catalyzed by carbonic anhydrases...
HFE gene knockout produces mouse model of hereditary hemochromatosis
Zhou, Xiao Yan, Tomatsu, Shunji, Fleming, Robert E., Parkkila, Seppo, Waheed, Abdul, Jiang, Jinxing, ...
Hereditary hemochromatosis (HH) is a common autosomal recessive disease characterized by increased iron absorption and progressive iron storage that results in damage to major organs in the body....
Parkkila, Seppo, Waheed, Abdul, Britton, Robert S., Feder, John N., Tsuchihashi, Zenta, Schatzman, Randall C., ...
Hereditary hemochromatosis (HH) is a common autosomal recessive disorder of iron metabolism that leads to excessive iron storage in the liver and other organs. Recently, between 83 and 100% of HH...
Parkkila, Seppo, Waheed, Abdul, Britton, Robert S., Bacon, Bruce R., Zhou, Xiao Yan, Tomatsu, Shunji, ...
Hereditary hemochromatosis (HH) is a common autosomal recessive disease associated with loss of regulation of dietary iron absorption and excessive iron deposition in major organs of the body....
Waheed, Abdul, Parkkila, Seppo, Zhou, Xiao Yan, Tomatsu, Shunji, Tsuchihashi, Zenta, Feder, John N., ...
Hereditary hemochromatosis (HH) is the most common autosomal recessive disorder known in humans. A candidate gene for HH called HFE has recently been cloned that encodes a novel member of the major...
Parkkila, Seppo, Parkkila, Anna-Kaisa, Rajaniemi, Hannu, Shah, Gul N., Grubb, Jeffrey H., Waheed, Abdul, ...
Although long suspected from histochemical evidence for carbonic anhydrase (CA) activity on neurons and observations that CA inhibitors enhance the extracellular alkaline shifts associated with...
Karhumaa, Pepe, Leinonen, Jukka, Parkkila, Seppo, Kaunisto, Kari, Tapanainen, Juha, Rajaniemi, Hannu
In addition to essential nutrients, human milk contains several classes of bioactive factors such as enzymes, hormones, and growth factors, many of which are implicated in infantile growth and...
The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV
Parkkila, Seppo, Kivelä, Antti J, Kaunisto, Kari, Parkkila, Anna-Kaisa, Hakkola, Jukka, Rajaniemi, Hannu, ...
Halsted, Charles H., Villanueva, Jesus A., Devlin, Angela M., Niemelä, Onni, Parkkila, Seppo, Garrow, Timothy A., ...
Alcoholic liver disease is associated with abnormal hepatic methionine metabolism and folate deficiency. Because folate is integral to the methionine cycle, its deficiency could promote alcoholic...
Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs
Hynninen, Piritta, Hämäläinen, Jonna M, Pastorekova, Silvia, Pastorek, Jaromir, Waheed, Abdul, Sly, William S, ...
Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa
Kummola, Laura, Hämäläinen, Jonna M, Kivelä, Jyrki, Kivelä, Antti J, Saarnio, Juha, Karttunen, Tuomo, ...
Leppilampi, Mari, Parkkila, Seppo, Karttunen, Tuomo, Gut, Marta Ortova, Gros, Gerolf, Sjöblom, Markus
Duodenal bicarbonate secretion (DBS) is accepted as the primary mucosal defense against acid discharged from the stomach and is impaired in patients with duodenal ulcer disease. The secretory...
Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase
Hilvo, Mika, Tolvanen, Martti, Clark, Amy, Shen, Bairong, Shah, Gul N., Waheed, Abdul, ...
The main function of CAs (carbonic anhydrases) is to participate in the regulation of acid–base balance. Although 12 active isoenzymes of this family had already been described, analyses of genomic...
Expression of carbonic anhydrases IX and XII during mouse embryonic development
Kallio, Heini, Pastorekova, Silvia, Pastorek, Jaromir, Waheed, Abdul, Sly, William S, Mannisto, Susanna, ...
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
Waheed, Abdul, Parkkila, Seppo, Saarnio, Juha, Fleming, Robert E., Zhou, Xiao Yan, Tomatsu, Shunji, ...
In hereditary hemochromatosis (HH), intestinal absorption of dietary iron is increased, leading to excessive iron accumulation in tissues and resultant organ damage. The HFE protein, which is...
Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro
Parkkila, Seppo, Rajaniemi, Hannu, Parkkila, Anna-Kaisa, Kivelä, Jyrki, Waheed, Abdul, Pastoreková, Silvia, ...
Acidification of the extracellular milieu of malignant tumors is reported to increase the invasive behavior of cancer cells. In normal tissues, production of acid is catalyzed by carbonic anhydrases...
HFE gene knockout produces mouse model of hereditary hemochromatosis
Zhou, Xiao Yan, Tomatsu, Shunji, Fleming, Robert E., Parkkila, Seppo, Waheed, Abdul, Jiang, Jinxing, ...
Hereditary hemochromatosis (HH) is a common autosomal recessive disease characterized by increased iron absorption and progressive iron storage that results in damage to major organs in the body....
Parkkila, Seppo, Waheed, Abdul, Britton, Robert S., Feder, John N., Tsuchihashi, Zenta, Schatzman, Randall C., ...
Hereditary hemochromatosis (HH) is a common autosomal recessive disorder of iron metabolism that leads to excessive iron storage in the liver and other organs. Recently, between 83 and 100% of HH...
Parkkila, Seppo, Waheed, Abdul, Britton, Robert S., Bacon, Bruce R., Zhou, Xiao Yan, Tomatsu, Shunji, ...
Hereditary hemochromatosis (HH) is a common autosomal recessive disease associated with loss of regulation of dietary iron absorption and excessive iron deposition in major organs of the body....
Waheed, Abdul, Parkkila, Seppo, Zhou, Xiao Yan, Tomatsu, Shunji, Tsuchihashi, Zenta, Feder, John N., ...
Hereditary hemochromatosis (HH) is the most common autosomal recessive disorder known in humans. A candidate gene for HH called HFE has recently been cloned that encodes a novel member of the major...
Parkkila, Seppo, Parkkila, Anna-Kaisa, Rajaniemi, Hannu, Shah, Gul N., Grubb, Jeffrey H., Waheed, Abdul, ...
Although long suspected from histochemical evidence for carbonic anhydrase (CA) activity on neurons and observations that CA inhibitors enhance the extracellular alkaline shifts associated with...
Karhumaa, Pepe, Leinonen, Jukka, Parkkila, Seppo, Kaunisto, Kari, Tapanainen, Juha, Rajaniemi, Hannu
In addition to essential nutrients, human milk contains several classes of bioactive factors such as enzymes, hormones, and growth factors, many of which are implicated in infantile growth and...
The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV
Parkkila, Seppo, Kivelä, Antti J, Kaunisto, Kari, Parkkila, Anna-Kaisa, Hakkola, Jukka, Rajaniemi, Hannu, ...
Halsted, Charles H., Villanueva, Jesus A., Devlin, Angela M., Niemelä, Onni, Parkkila, Seppo, Garrow, Timothy A., ...
Alcoholic liver disease is associated with abnormal hepatic methionine metabolism and folate deficiency. Because folate is integral to the methionine cycle, its deficiency could promote alcoholic...
Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs
Hynninen, Piritta, Hämäläinen, Jonna M, Pastorekova, Silvia, Pastorek, Jaromir, Waheed, Abdul, Sly, William S, ...
Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa
Kummola, Laura, Hämäläinen, Jonna M, Kivelä, Jyrki, Kivelä, Antti J, Saarnio, Juha, Karttunen, Tuomo, ...
Leppilampi, Mari, Parkkila, Seppo, Karttunen, Tuomo, Gut, Marta Ortova, Gros, Gerolf, Sjöblom, Markus
Duodenal bicarbonate secretion (DBS) is accepted as the primary mucosal defense against acid discharged from the stomach and is impaired in patients with duodenal ulcer disease. The secretory...
Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase
Hilvo, Mika, Tolvanen, Martti, Clark, Amy, Shen, Bairong, Shah, Gul N., Waheed, Abdul, ...
The main function of CAs (carbonic anhydrases) is to participate in the regulation of acid–base balance. Although 12 active isoenzymes of this family had already been described, analyses of genomic...
Expression of carbonic anhydrases IX and XII during mouse embryonic development
Kallio, Heini, Pastorekova, Silvia, Pastorek, Jaromir, Waheed, Abdul, Sly, William S, Mannisto, Susanna, ...
Carbonic anhydrase gene expression in CA II-deficient (Car2−/−) and CA IX-deficient (Car9−/−) mice
Pan, Peiwen, Leppilampi, Mari, Pastorekova, Silvia, Pastorek, Jaromir, Waheed, Abdul, Sly, William S, ...
Using real-time PCR and immunohistochemistry, we have examined the expression of carbonic anhydrase isozymes (CA) I, II, III, IV, IX, XII, XIII and XIV in the brain, kidney, stomach and colon of the...
Saarnio, Juha, Parkkila, Seppo, Parkkila, Anna-Kaisa, Haukipuro, Kari, Pastoreková, Silvia, Pastorek, Jaromir, ...
Carbonic anhydrase isoenzyme IX, MN/CA IX, is a recently discovered member of the carbonic anhydrase (CA) gene family with a suggested function in acid-base balance, intercellular communication, and...
Kivelä, Antti, Parkkila, Seppo, Saarnio, Juha, Karttunen, Tuomo J., Kivelä, Jyrki, Parkkila, Anna-Kaisa, ...
Carbonic anhydrase isozyme XII is a recently discovered member of the α-carbonic anhydrase gene family with a suggested role in von Hippel-Lindau gene-mediated carcinogenesis. Increased expression...
Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse
Rodriguez, Alejandra, Hilvo, Mika, Kytömäki, Leena, Fleming, Robert E, Britton, Robert S, Bacon, Bruce R, ...
Carbonic anhydrase IX in oligodendroglial brain tumors
Järvelä, Sally, Parkkila, Seppo, Bragge, Helena, Kähkönen, Marketta, Parkkila, Anna-Kaisa, Soini, Ylermi, ...
The calcium-binding protein S100P in normal and malignant human tissues
Parkkila, Seppo, Pan, Pei-wen, Ward, Aoife, Gibadulinova, Adriana, Oveckova, Ingrid, Pastorekova, Silvia, ...
Salivary carbonic anhydrase isoenzyme VI
Kivelä, Jyrki, Parkkila, Seppo, Parkkila, Anna-Kaisa, Leinonen, Jukka, Rajaniemi, Hannu
The carbonic anhydrases (CAs) participate in the maintenance of pH homeostasis in various tissues and biological fluids of the human body by catalysing the reversible reaction CO2+ H2O ⇌ HCO3−+...
Carbonic anhydrase II in the endothelium of glial tumors: A potential target for therapy
Haapasalo, Joonas, Nordfors, Kristiina, Järvelä, Sally, Bragge, Helena, Rantala, Immo, Parkkila, Anna-Kaisa, ...
Carbonic anhydrase isozyme II (CA II) is a cytosolic enzyme that is highly expressed in most organs, including the brain, where it is mainly located in the oligodendrocytes. Recent studies have shown...
Bootorabi, Fatemeh, Jänis, Janne, Valjakka, Jarkko, Isoniemi, Sari, Vainiotalo, Pirjo, Vullo, Daniela, ...
Haapasalo, Joonas, Hilvo, Mika, Nordfors, Kristiina, Haapasalo, Hannu, Parkkila, Seppo, Hyrskyluoto, Alise, ...
Carbonic anhydrase XII (CA XII) is a transmembrane enzyme that is associated with neoplastic growth. CA XII has been proposed to be involved in acidification of the extracellular milieu, creating an...
Expression of iron-related genes in human brain and brain tumors
Hänninen, Milla M, Haapasalo, Joonas, Haapasalo, Hannu, Fleming, Robert E, Britton, Robert S, Bacon, Bruce R, ...
Rodriguez, Alejandra, Luukkaala, Tiina, Fleming, Robert E., Britton, Robert S., Bacon, Bruce R., Parkkila, Seppo
Iron is an essential trace element whose absorption is usually tightly regulated in the duodenum. HFE-related hereditary hemochromatosis (HH) is characterized by abnormally low expression of the...