Derek A. Roff, Serge Mostowy, Daphne J. Fairbairn
The concept of phenotypic trade-offs is a central element in evolutionary theory. In general, phenotypic models assume a fixed trade-off function, whereas quantitative genetic theory predicts that...
Quantitative genetics has traditionally been used to examine selection responses in domesticated organisms, but has recently been applied by evolutionary biologists to natural populations....
Written for the Dept. of Biology.
Quantitative genetics has traditionally been used to examine selection responses in domesticated organisms, but has recently been applied by evolutionary biologists to natural populations....
Mostowy, Serge, Cousins, Debby, Behr, Marcel A.
Despite their remarkable genetic homology, members of the Mycobacterium tuberculosis complex express very different phenotypes, most notably in their spectra of clinical presentation. For example, M....
Nguyen, Dao, Brassard, Paul, Menzies, Dick, Thibert, Louise, Warren, Rob, Mostowy, Serge, ...
In a study of 302 Mycobacterium tuberculosis clinical isolates from the low-incidence Canadian-born population of Quebec, we characterized a large endemic strain family by using genomic deletions....
Genomic Analysis Distinguishes Mycobacterium africanum
Mostowy, Serge, Onipede, Anthony, Gagneux, Sebastien, Niemann, Stefan, Kremer, Kristin, Desmond, Edward P., ...
Mycobacterium africanum is thought to comprise a unique species within the Mycobacterium tuberculosis complex. M. africanum has traditionally been identified by phenotypic criteria, occupying an...
Extensive Genomic Polymorphism within Mycobacterium avium†
Semret, Makeda, Zhai, Gary, Mostowy, Serge, Cleto, Cynthia, Alexander, David, Cangelosi, Gerard, ...
We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium...
Revisiting the Evolution of Mycobacterium bovis
Mostowy, Serge, Inwald, Jackie, Gordon, Steve, Martin, Carlos, Warren, Rob, Kremer, Kristin, ...
Though careful consideration has been placed towards genetic characterization of tubercle bacillus isolates causing disease in humans, those causing disease predominantly among wild and domesticated...
Mostowy, Serge, Cousins, Debby, Behr, Marcel A.
Despite their remarkable genetic homology, members of the Mycobacterium tuberculosis complex express very different phenotypes, most notably in their spectra of clinical presentation. For example, M....
Nguyen, Dao, Brassard, Paul, Menzies, Dick, Thibert, Louise, Warren, Rob, Mostowy, Serge, ...
In a study of 302 Mycobacterium tuberculosis clinical isolates from the low-incidence Canadian-born population of Quebec, we characterized a large endemic strain family by using genomic deletions....
Genomic Analysis Distinguishes Mycobacterium africanum
Mostowy, Serge, Onipede, Anthony, Gagneux, Sebastien, Niemann, Stefan, Kremer, Kristin, Desmond, Edward P., ...
Mycobacterium africanum is thought to comprise a unique species within the Mycobacterium tuberculosis complex. M. africanum has traditionally been identified by phenotypic criteria, occupying an...
Extensive Genomic Polymorphism within Mycobacterium avium†
Semret, Makeda, Zhai, Gary, Mostowy, Serge, Cleto, Cynthia, Alexander, David, Cangelosi, Gerard, ...
We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium...
Revisiting the Evolution of Mycobacterium bovis
Mostowy, Serge, Inwald, Jackie, Gordon, Steve, Martin, Carlos, Warren, Rob, Kremer, Kristin, ...
Though careful consideration has been placed towards genetic characterization of tubercle bacillus isolates causing disease in humans, those causing disease predominantly among wild and domesticated...
Sancho-Shimizu, Vanessa, Khan, Rabia, Mostowy, Serge, Larivière, Line, Wilkinson, Rosalie, Riendeau, Noémie, ...
Numerous genes have been identified to date that contribute to the host response to systemic Salmonella Typhimurium infection in mice. We have previously identified two loci, Ity2 and Ity3, that...
Geier, Henriette, Mostowy, Serge, Cangelosi, Gerard A., Behr, Marcel A., Ford, Timothy E.
Mycobacterium avium is an environmental organism and opportunistic pathogen with inherent resistance to drugs, environmental stresses, and the host immune response. To adapt to these disparate...
PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence
Gonzalo-Asensio, Jesús, Mostowy, Serge, Harders-Westerveen, Jose, Huygen, Kris, Hernández-Pando, Rogelio, Thole, Jelle, ...
Inactivation of the transcriptional regulator PhoP results in Mycobacterium tuberculosis attenuation. Preclinical testing has shown that attenuated M. tuberculosis phoP mutants hold promise as safe...
Septins Regulate Bacterial Entry into Host Cells
Mostowy, Serge, Nam Tham, To, Danckaert, Anne, Guadagnini, Stéphanie, Boisson-Dupuis, Stéphanie, Pizarro-Cerdá, Javier, ...
Septin 11 Restricts InlB-mediated Invasion by ListeriaS⃞
Mostowy, Serge, Danckaert, Anne, Tham, To Nam, Machu, Christophe, Guadagnini, Stéphanie, Pizarro-Cerdá, Javier, ...
Septins are filament-forming GTPases implicated in several cellular functions, including cytokinesis. We previously showed that SEPT2, SEPT9, and SEPT11 colocalize with several bacteria entering into...