Sergei B. Koralov

Direct in vivo VH to JH rearrangement violating the 12/23 rule

Koralov, Sergei B., Novobrantseva, Tatiana I., Hochedlinger, Konrad, Jaenisch, Rudolf, Rajewsky, Klaus

V(D)J recombination at the immunoglobulin heavy chain (IgH) locus follows the 12/23 rule to ensure the correct assembly of the variable region gene segments. Here, we report characterization of an in...

Tracking germinal center B cells expressing germ-line immunoglobulin γ1 transcripts by conditional gene targeting

Casola, Stefano, Cattoretti, Giorgio, Uyttersprot, Nathalie, Koralov, Sergei B., Segal, Jane, Hao, Zhenyue, ...

Germinal centers (GCs) represent the main sites for the generation of high-affinity, class-switched antibodies during T cell-dependent antibody responses. To study gene function specifically in GC B...

Tracking germinal center B cells expressing germ-line immunoglobulin γ1 transcripts by conditional gene targeting

Casola, Stefano, Cattoretti, Giorgio, Uyttersprot, Nathalie, Koralov, Sergei B., Seagal, Jane, Hao, Zhenyue, ...

Germinal centers (GCs) represent the main sites for the generation of high-affinity, class-switched antibodies during T cell-dependent antibody responses. To study gene function specifically in GC B...

Direct in vivo VH to JH rearrangement violating the 12/23 rule

Koralov, Sergei B., Novobrantseva, Tatiana I., Hochedlinger, Konrad, Jaenisch, Rudolf, Rajewsky, Klaus

V(D)J recombination at the immunoglobulin heavy chain (IgH) locus follows the 12/23 rule to ensure the correct assembly of the variable region gene segments. Here, we report characterization of an in...

Complement C4 Inhibits Systemic Autoimmunity through a Mechanism Independent of Complement Receptors Cr1 and Cr2

Chen, Zhibin, Koralov, Sergei B., Kelsoe, Garnett

The complement system enhances antibody responses to T-dependent antigens, but paradoxically, deficiencies in C1 and C4 are strongly linked to autoantibody production in humans. In mice, disruption...