Ali M Ardekani, Ben A Hitt, Peter J Levine, Vincent A Fusaro, Seth M Steinberg, ...
Background New technologies for the detection of earlystage ovarian cancer are urgently needed. Pathological changes within an organ might be reflected in proteomic patterns in serum. We developed a...
BRIEF COMMUNICATIONS Serum Proteomic Patterns for Detection of Prostate Cancer (2008)
David K, Cloud P. Paweletz, Paul S. Hackett, Ben A, Alfredo Velassco, ...
Pathologic states within the prostate may be reflected by changes in serum proteomic patterns. To test this hypothesis, we analyzed serum proteomic mass spectra with a bioinformatics tool to reveal...
Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain (2008)
Gril, Brunilde, Palmieri, Diane, Bronder, Julie L., Herring, Jeanne M., Vega-Valle, Eleazar, Feigenbaum, Lionel, ...
Background The brain is increasingly being recognized as a sanctuary site for metastatic tumor cells in women with HER2-overexpressing breast cancer who receive trastuzumab therapy. There are no...
Blackman, Marc R, Muniyappa, Ranganath, Wilson, Mildred, Moquin, Barbara E, Baldwin, Howard L, Wong, Kelli A, ...
Abstract Rheumatoid arthritis (RA) is associated with neuroendocrine and immunologic dysfunction leading to rheumatoid cachexia. Although excess proinflammatory cytokines can decrease somatotropic...
Tsurutani, Junji, Steinberg, Seth M, Ballas, Marc, Robertson, Matthew, LoPiccolo, Jaclyn, Soda, Hiroshi, ...
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Palmieri, Diane, Halverson, Douglas O., Ouatas, Taoufik, Horak, Christine E., Salerno, Massimiliano, Johnson, Jennifer, ...
Background: Reestablishment of metastasis suppressor gene expression may constitute a therapeutic strategy for high-risk breast cancer patients. We previously showed that medroxyprogesterone acetate...
Serum Proteomic Patterns for Detection of Prostate Cancer (2002)
Petricoin, Emanuel F., Ornstein, David K., Paweletz, Cloud P., Ardekani, Ali, Hackett, Paul S., Hitt, Ben A., ...
Pathologic states within the prostate may be reflected by changes in serum proteomic patterns. To test this hypothesis, we analyzed serum proteomic mass spectra with a bioinformatics tool to reveal...
Kelley, Michael J., Nakagawa, Kazuhiko, Steinberg, Seth M., Mulshine, James L., Kamb, Alexander, Johnson, Bruce E.
Background: The CDKN2 gene encodes the human cyclin-dependent kinase 4 inhibitor. This inhibitor protein is believed to be a tumor suppressor that plays an essential role in cell cycle regulation....
Obesity and Therapy-Related Toxicity in Patients Treated for Small-Cell Lung Cancer (1995)
Georgiadis, Mark S., Steinberg, Seth M., Hankins, Lynn A., Ihde, Daniel C., Johnson, Bruce E.
Background Obese individuals have altered pharmacokinetics for many medications when compared with the non-obese. For the oncologist treating an obese cancer patient, these changes in drug...
Kohn, Elise C., Sarosy, Gisele, Bicher, Annette, Link, Charles, Christian, Michaele, Steinberg, Seth M., ...
Background Paclitaxel (Taxol), a diterpene plant product that promotes tubulin polymerization, has documented activity against a number of solid tumors, including ovarian cancer and breast cancer...
Rosenberg, Steven A., Lotze, Michael T., Yang, James C., Topalian, Suzanne L., Chang, Alfred E., Schwartzentruber, Douglas J., ...
Background: Treatment using interleukin-2 (IL-2) alone or in conjunction with lymphokine-activated killer (LAK) cells has been shown to mediate disease regression in selected patients with advanced...
Yee, Lorrin K., Allegra, Carmen J., Steinberg, Seth M., Grem, Jean L.
Background: We previously reported that recombinant interferon α-2a (IFN α-2a) therapy was associated with a dose-dependent decrease in fluorouracil (5-FU) clearance. Purpose: In this study, we...
Gazdar, Adi F., Steinberg, Seth M., Russell, Edward K., Linnoila, R. Ilona, Oie, Herbert K., Ghosh, Bimal C., ...
We devised a novel clinical protocol for extensive-stage small cell lung cancer (SCLC), selecting chemotherapy whenever possible on the basis of in vitro drug-sensitivity testing (DST) of individual...
Rothenberg, Mace L, Ostchega, Yechiam, Steinberg, Seth M., Young, Robert C., Hummel, Sherifynn, Ozols, Robert F.
Diethyldithiocarbamate (DDTC) has been found to protect the bone marrow, kidneys, and gastrointestinal tract, from the toxic effects of cisplatin and carboplatin (CBDCA) in animal mod-1 els. In an...
Park, Jae-Gahb, Collins, Jerry M., Gazdar, Adi F., Allegra, Carmen J., Steinberg, Seth M., Greene, Raymond F., ...
Reduced folates have been shown to increase the cytotoxicity of 5-fluorouracil (5-FU) by stabilizing the 5-fluoro-2′-deoxyuridine-5′-monophosphate-thymidylate synthase complex, thus increasing...
Petiniot, Lisa K., Weaver, Zoë, Barlow, Carrolee, Shen, Rhuna, Eckhaus, Michael, Steinberg, Seth M., ...
The majority of Atm-deficient mice die of malignant thymic lymphoma by 4–5 mo of age. Cytogenetic abnormalities in these tumors are consistently identified within the Tcr α/δ locus, suggesting...
Blazevic, Vesna, Jankelevich, Shirley, Steinberg, Seth M., Jacobsen, Freda, Yarchoan, Robert, Shearer, Gene M.
The present study analyzes the effect of highly active antiretroviral therapy (HAART) on restoration of cellular immunity in human immunodeficiency virus (HIV)-infected children over a 24-week period...
RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice
Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, ...
Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA...
Phan, Giao Q., Yang, James C., Sherry, Richard M., Hwu, Patrick, Topalian, Suzanne L., Schwartzentruber, Douglas J., ...
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and a subset of regulatory T cells) capable of down-regulating T cell...
Hazra, Rohan, Balis, Frank M., Tullio, Antonella N., DeCarlo, Ellen, Worrell, Carol J., Steinberg, Seth M., ...
Tenofovir disoproxil fumarate (DF) is a potent nucleotide analog reverse transcriptase inhibitor approved for the treatment of human immunodeficiency virus (HIV)-infected adults. The single-dose and...
Could Human Papillomaviruses Be Spread through Blood?
Bodaghi, Sohrab, Wood, Lauren V., Roby, Gregg, Ryder, Celia, Steinberg, Seth M., Zheng, Zhi-Ming
The human papillomaviruses (HPVs) are epitheliotropic viruses that require the environment of a differentiating squamous epithelium for their life cycle. HPV infection through abrasion of the skin or...
Wei, Jun S., Greer, Braden T., Westermann, Frank, Steinberg, Seth M., Son, Chang-Gue, Chen, Qing-Rong, ...
Currently, patients with neuroblastoma are classified into risk groups (e.g., according to the Children’s Oncology Group risk-stratification) to guide physicians in the choice of the most...
Petiniot, Lisa K., Weaver, Zoë, Barlow, Carrolee, Shen, Rhuna, Eckhaus, Michael, Steinberg, Seth M., ...
The majority of Atm-deficient mice die of malignant thymic lymphoma by 4–5 mo of age. Cytogenetic abnormalities in these tumors are consistently identified within the Tcr α/δ locus, suggesting...
Blazevic, Vesna, Jankelevich, Shirley, Steinberg, Seth M., Jacobsen, Freda, Yarchoan, Robert, Shearer, Gene M.
The present study analyzes the effect of highly active antiretroviral therapy (HAART) on restoration of cellular immunity in human immunodeficiency virus (HIV)-infected children over a 24-week period...
RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice
Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, ...
Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA...
Phan, Giao Q., Yang, James C., Sherry, Richard M., Hwu, Patrick, Topalian, Suzanne L., Schwartzentruber, Douglas J., ...
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and a subset of regulatory T cells) capable of down-regulating T cell...
Hazra, Rohan, Balis, Frank M., Tullio, Antonella N., DeCarlo, Ellen, Worrell, Carol J., Steinberg, Seth M., ...
Tenofovir disoproxil fumarate (DF) is a potent nucleotide analog reverse transcriptase inhibitor approved for the treatment of human immunodeficiency virus (HIV)-infected adults. The single-dose and...
Could Human Papillomaviruses Be Spread through Blood?
Bodaghi, Sohrab, Wood, Lauren V., Roby, Gregg, Ryder, Celia, Steinberg, Seth M., Zheng, Zhi-Ming
The human papillomaviruses (HPVs) are epitheliotropic viruses that require the environment of a differentiating squamous epithelium for their life cycle. HPV infection through abrasion of the skin or...
Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma
Little, Richard F., Pluda, James M., Wyvill, Kathleen M., Rodriguez-Chavez, Isaac R., Tosato, Giovanna, Catanzaro, Andrew T., ...
Interleukin-12 (IL-12) enhances Th1-type T-cell responses and exerts antiangiogenic effects. We initiated a phase 1 pilot study of IL-12 in 32 patients with acquired immunodeficiency syndrome...
Blackman, Marc R, Muniyappa, Ranganath, Wilson, Mildred, Moquin, Barbara E, Baldwin, Howard L, Wong, Kelli A, ...
Rheumatoid arthritis (RA) is associated with neuroendocrine and immunologic dysfunction leading to rheumatoid cachexia. Although excess proinflammatory cytokines can decrease somatotropic axis...
Toro, Jorge R., Pautler, Stephen E., Stewart, Laveta, Glenn, Gladys M., Weinreich, Michael, Toure, Ousmane, ...
Rationale: Birt-Hogg-Dubé syndrome (BHDS) is an autosomal, dominantly inherited genodermatosis that predisposes to fibrofolliculomas, kidney neoplasms, lung cysts, and spontaneous pneumothorax.
Nakata, Hirotomo, Steinberg, Seth M., Koh, Yasuhiro, Maeda, Kenji, Takaoka, Yoshikazu, Tamamura, Hirokazu, ...
Aplaviroc (AVC), an experimental CCR5 inhibitor, potently blocks in vitro the infection of R5-tropic human immunodeficiency virus type 1 (R5-HIV-1) at subnanomolar 50% inhibitory concentrations....
Little, Richard F., Aleman, Karen, Kumar, Pallavi, Wyvill, Kathleen M., Pluda, James M., Read-Connole, Elizabeth, ...
Thirty-six patients with AIDS-associated Kaposi sarcoma (KS) requiring chemotherapy were treated for six 3-week cycles of pegylated liposomal doxorubicin (20 mg/m2) plus interleukin-12 (IL-12; 300...