Scientific Commons: Settara C. Chandrasekharappa

The human homolog of the Saccharomyces cerevisiae cell division control 27 gene (CDC27) was mapped to human chromosome 17q12-q21 using a panel of human/rodent somatic cell hybrids and localized...

Characterization of 10 New Polymorphic Dinucleotide Repeats and Generation of a High-Density Microsatellite-Based Physical Map of the BRCA1 Region of Chromosome 17q21 (1994)

Couch, Fergus J., Kiousis, Sam, Castilla, Lucio H., Xu, Junzhe, Chandrasekharappa, Settara C., Chamberlain, Jeffrey S., ...

A familial early onset breast cancer gene (BRCA1) has been localized to chromosome 17q21. To aid in the identification of this gene a number of new microsatellite markers from the D17S857 to D17S78...

Multicolor FISH Mapping of YAC Clones in 3p14 and Identification of a YAC Spanning both FRA3B and the t(3;8) Associated with Hereditary Renal Cell Carcinoma (1994)

Wilke, Charles M., Guo, Sun-Wei, Hall, Bryan K., Boldog, Ferenc, Gemmill, Robert M., Chandrasekharappa, Settara C., ...

Human chromosome band 3p14 contains two tightly linked cytogenetic markers of broad interest, FRA3B and the t(3;8) breakpoint associated with hereditary renal cell carcinoma (RCC). The common fragile...

The Gene for Pancreatic Polypeptide (PPY) and the Anonymous Marker D17S78 Are within 45 kb of Each Other on Chromosome 17q21 (1994)

Chandrasekharappa, Settara C., Friedman, Lori, King, Stephanie E., Lee, Yoon-Hee, Welsch, Piri, Bowcock, Anne M., ...

Peer Reviewed

The CA repeat marker D17S791 islocated within 40 kb of the WNT3 gene on chromosome 17q (1993)

Chandrasekharappa, Settara C., King, Stephanie E., Freedman, Matthew L., Hayes, Steve T., Bowcock, Anne M., Collins, Francis S.

Peer Reviewed

Multicolor FISH Mapping with Alu-PCR-Amplified YAC Clone DNA Determines the Order of Markers in the BRCA1 Region on Chromosome 17q12-q21 (1993)

Flejter, Wendy L., Barcroft, Christine L., Guo, Sun-Wei, Lynch, Eric D., Boehnke, Michael, Chandrasekharappa, Settara C., ...

A gene designated BRCA1, implicated in the susceptibility to early-onset familial breast cancer, has recently been localized to chromosome 17q12-q21. To date, the order of DNA markers mapped within...

A Radiation Hybrid Map of the BRCA1 Region of Chromosome 17q12-q21 (1993)

Abel, Kenneth J., Boehnke, Michael, Prahalad, Murali, Ho, Peggy P., Flejter, Wendy L., Watkins, Melanie, ...

The chromosomal region 17q12-q21 contains a gene (BRCA1) conferring susceptibility to early-onset familial breast and ovarian cancer. An 8000-rad radiation-reduced hybrid (RH) panel was constructed...

Human PCK1 Encoding Phosphoenolpyruvate Carboxykinase Is Located on Chromosome 20q13.2 (1993)

Yu, Hua, Thun, Rachel, Chandrasekharappa, Settara C., Trent, Jeffrey M., Zhang, Ji, Meisler, Miriam H.

Cytoplasmic liver phosphoenolpyruvate carboxykinase (GTP)(PEPCK) catalyzes a rate-limiting step in gluconeogenesis. Primers derived from the rat liver PEPCK sequence were used to amplify a portion of...

Tetranucleotide repeat polymorphism at D17S846 maps within 40 kb of GAS at 17q12-q22 (1993)

Flejter, Wendy L., Kukowska-Latallo, Jolanta F., Kiousis, Sam, Chandrasekharappa, Settara C., King, Stephanie E., Chamberlain, Jeffrey S.

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

Crabtree, Judy S., Scacheri, Peter C., Ward, Jerrold M., Garrett-Beal, Lisa, Emmert-Buck, Michael R., Edgemon, Keith A., ...

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant cancer syndrome, characterized primarily by multiple tumors in the parathyroid glands, endocrine pancreas, and anterior pituitary....

Menin, the product of the MEN1 gene, is a nuclear protein

Guru, Siradanahalli C., Goldsmith, Paul K., Burns, A. Lee, Marx, Stephen J., Spiegel, Allen M., Collins, Francis S., ...

The MEN1 gene, mutations in which are responsible for multiple endocrine neoplasia type 1 (MEN1), encodes a 610-amino acid protein, denoted menin. The amino acid sequence of this putative tumor...

The 32-Kilodalton Subunit of Replication Protein A Interacts with Menin, the Product of the MEN1 Tumor Suppressor Gene

Sukhodolets, Karen E., Hickman, Alison B., Agarwal, Sunita K., Sukhodolets, Maxim V., Obungu, Victor H., Novotny, Elizabeth A., ...

Menin is a 70-kDa protein encoded by MEN1, the tumor suppressor gene disrupted in multiple endocrine neoplasia type 1. In a yeast two-hybrid system based on reconstitution of Ras signaling, menin was...

Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout

Crabtree, Judy S., Scacheri, Peter C., Ward, Jerrold M., McNally, Sara R., Swain, Gary P., Montagna, Cristina, ...

Patients with multiple endocrine neoplasia type 1 (MEN1) develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and endocrine pancreas, due to the inactivation of the MEN1...

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

Agarwal, Sunita K., Novotny, Elizabeth A., Crabtree, Judy S., Weitzman, Jonathan B., Yaniv, Moshe, Burns, A. Lee, ...

Different components of the AP1 transcription factor complex appear to have distinct effects on cell proliferation and transformation. In contrast to other AP1 components, JunD has been shown to...

A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus

Guru, Siradanahalli C., Agarwal, Sunita K., Manickam, Pachiappan, Olufemi, Shodimu-Emmanuel, Crabtree, Judy S., Weisemann, Jane M., ...

Multiple endocrine neoplasia type 1 (MEN 1) is an inherited cancer syndrome in which affected individuals develop multiple parathyroid, enteropancreatic, and pituitary tumors. The locus for MEN1 is...