Scheinfeldt, Laura B., Biswas, Shameek, Madeoy, Jennifer, Connelly, Caitlin F., Schadt, Eric E., Akey, Joshua M.
Mutations in the human gene ALMS1 result in Alström Syndrome, which presents with early childhood obesity and insulin resistance leading to Type 2 diabetes. Previous genomewide scans for selection...
Biswas, Shameek, Storey, John D, Akey, Joshua M
Abstract Background The combination of gene expression profiling with linkage analysis has become a powerful paradigm for mapping gene expression quantitative trait loci (eQTL). To date, most studies...
G.Hripcsak, “Analysis of variance of cross-validation estimators of the generalization error (2005)
Marianthi Markatou, Hong Tian, Shameek Biswas, George Hripcsak, David Madigan
This paper brings together methods from two different disciplines: statistics and machine learning. We address the problem of estimating the variance of cross-validation (CV) estimators of the...
Genome-wide Insights into the Patterns and Determinants of Fine-Scale Population Structure in Humans
Biswas, Shameek, Scheinfeldt, Laura B., Akey, Joshua M.
Studying genomic patterns of human population structure provides important insights into human evolutionary history and the relationship among populations, and it has significant practical...