Derudder, Emmanuel, Cadera, Emily J., Val, J. Christoph, Wang, Jing, Fox, Casey J., Zha, Shan, ...
By genetically ablating I kappa B kinase (IKK)-mediated activation of the transcription factor NF-kappa B in the B cell lineage and by analyzing a mouse mutant in which immunoglobulin...
Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells
Zha, Shan, Alt, Frederick W., Cheng, Hwei-Ling, Brush, James W., Li, Gang
Nonhomologous DNA end-joining (NHEJ) is a major pathway of DNA double-strand break (DSB) repair in mammalian cells, and it functions to join both specifically programmed DSBs that occur in the...
Complementary functions of ATM and H2AX in development and suppression of genomic instability
Zha, Shan, Sekiguchi, JoAnn, Brush, James W., Bassing, Craig H., Alt, Frederick W.
Upon DNA damage, histone H2AX is phosphorylated by ataxia-telangiectasia mutated (ATM) and other phosphoinositide 3-kinase-related protein kinases. To elucidate further the potential overlapping and...