Fernando, Himesh, Sewitz, Sven, Darot, Jeremy, Tavaré, Simon, Huppert, Julian Leon, Balasubramanian, Shankar
G-quadruplex nucleic acids have been proposed to play a role in a number of fundamental biological processes that include transcription and translation. We have developed a single-chain antibody that...
Accurate whole human genome sequencing using reversible terminator chemistry (2008)
Bentley, David R., Balasubramanian, Shankar, Swerdlow, Harold P., Smith, Geoffrey P., Milton, John, Brown, Clive G., ...
DNA sequence information underpins genetic research, enabling discoveries of important biological or medical benefit. Sequencing projects have traditionally used long (400-800 base pair) reads, but...
Strong antimicrobial coatings: single-walled carbon nanotubes armored with biopolymers. (2008)
Nepal, Dhriti, Balasubramanian, Shankar, Simonian, Aleksandr L., Davis, Virginia A.
Large scale biomimetic single-walled carbon nanotube (SWNT) coatings with significant antimicrobial activity, high Young's Modulus, and controlled morphology were fabricated using layer-by-layer...
G-quadruplexes: the beginning and end of UTRs (2008)
Huppert, Julian Leon, Bugaut, Anthony, Kumari, Sunita, Balasubramanian, Shankar
Molecular mechanisms that regulate gene expression can occur either before or after transcription. The information for post-transcriptional regulation can lie within the sequence or structure of the...
Enzyme-Encapsulated Silica Monolayers for Rapid Functionalization of a Gold Surface PREPRINT (2007)
Luckarift, Heather R., Johnson, Glenn R., Balasubramanian, Shankar, Paliwal, Sheetal, Simonian, Aleksandr L.
We report a simple and rapid method for the deposition of amorphous silica onto a gold surface. The method is based on the ability of lysozyme to mediate the formation of silica nanoparticles. A...
Bhargava, B. L., Devane, R, Klein, M. L., Balasubramanian, Shankar
A model to perform coarse grained molecular dynamics simulations of room temperature ionic liquids of the family 1-n-alkyl-3-methylimidazolium hexafluorophosphate has been developed. Large scale...
G-quadruplexes in promoters throughout the human genome (2007)
Huppert, Julian L., Balasubramanian, Shankar
Certain G-rich DNA sequences readily form four-stranded structures called G-quadruplexes. These sequence motifs are located in telomeres as a repeated unit, and elsewhere in the genome, where their...
Exploring the Recognition of Quadruplex DNA by an Engineered Cys2-His2 Zinc Finger Protein (2006)
Ladame, Sylvian, Schouten, James A., Roldan, Jose, Redman, James Edward, Neidle, Stephen, Balasubramanian, Shankar
Exploring the Recognition of Quadruplex DNA by an Engineered Cys2-His2 Zinc Finger Protein (2006)
Ladame, Sylvian, Schouten, James A., Roldan, Jose, Redman, James Edward, Neidle, Stephen, Balasubramanian, Shankar
G-quadruplexes in promoters throughout the human genome (2006)
Huppert, Julian L., Balasubramanian, Shankar
Certain G-rich DNA sequences readily form four-stranded structures called G-quadruplexes. These sequence motifs are located in telomeres as a repeated unit, and elsewhere in the genome, where their...
G-quadruplexes in promoters throughout the human genome (2006)
Huppert, Julian L., Balasubramanian, Shankar
Certain G-rich DNA sequences readily form four-stranded structures called G-quadruplexes. These sequence motifs are located in telomeres as a repeated unit, and elsewhere in the genome, where their...
Prevalence of quadruplexes in the human genome (2005)
Huppert, Julian L., Balasubramanian, Shankar
Guanine-rich DNA sequences of a particular form have the ability to fold into four-stranded structures called G-quadruplexes. In this paper, we present a working rule to predict which primary...
Decision directed channel estimation in OFDM systems using embedded pilots / (2003)
Includes abstract.
Ren, Xiaojun, Gavory, Gérald, Li, Haitao, Ying, Liming, Klenerman, David, Balasubramanian, Shankar
The enzyme telomerase is a ribonucleoprotein that has a critical role in the maintenance of stable telomeres in organisms that possess linear chromosomes. Using a recently developed single molecule...
G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection (2003)
Schouten, James A., Ladame, Sylvain, Mason, Stephen J., Cooper, Matthew A., Balasubramanian, Shankar
G-quadruplex DNA-specific ligands were generated using a combinatorial selection of tetrapeptides which were then conjugated to a hemicyanine scaffold. The heterocycle enhanced peptide binding...
Gavory, Gérald, Farrow, Mark, Balasubramanian, Shankar
Telomeres are essential for genomic stability and cell viability. Telomerase, the enzyme responsible for telomere maintenance, is composed of a reverse transcriptase protein subunit and an integral...
Typescript.
Studies on the reaction mechanism of chorismate synthase. (1991)
Thesis (Ph. D.)--University of Cambridge, 1991.
Non-Arrhenius kinetics for the loop closure of a DNA hairpin
Wallace, Mark I., Ying, Liming, Balasubramanian, Shankar, Klenerman, David
Intramolecular chain diffusion is an elementary process in the conformational fluctuations of the DNA hairpin-loop. We have studied the temperature and viscosity dependence of a model DNA...
Gavory, Gérald, Farrow, Mark, Balasubramanian, Shankar
Telomeres are essential for genomic stability and cell viability. Telomerase, the enzyme responsible for telomere maintenance, is composed of a reverse transcriptase protein subunit and an integral...
Ren, Xiaojun, Gavory, Gérald, Li, Haitao, Ying, Liming, Klenerman, David, Balasubramanian, Shankar
The enzyme telomerase is a ribonucleoprotein that has a critical role in the maintenance of stable telomeres in organisms that possess linear chromosomes. Using a recently developed single molecule...
Ying, Liming, Green, Jeremy J., Li, Haitao, Klenerman, David, Balasubramanian, Shankar
We have investigated the structure and unfolding kinetics of the human telomeric intramolecular G quadruplex by using single-molecule fluorescence resonance energy transfer. An exploration of...
Li, Haitao, Ren, Xiaojun, Ying, Liming, Balasubramanian, Shankar, Klenerman, David
This work presents a general method for determining single-molecule intramolecular dynamics in biomolecules by using a reporter fluorophore, whose fluorescence is quenched or partially quenched as a...
Prevalence of quadruplexes in the human genome
Huppert, Julian L., Balasubramanian, Shankar
Guanine-rich DNA sequences of a particular form have the ability to fold into four-stranded structures called G-quadruplexes. In this paper, we present a working rule to predict which primary...
Non-Arrhenius kinetics for the loop closure of a DNA hairpin
Wallace, Mark I., Ying, Liming, Balasubramanian, Shankar, Klenerman, David
Intramolecular chain diffusion is an elementary process in the conformational fluctuations of the DNA hairpin-loop. We have studied the temperature and viscosity dependence of a model DNA...
Gavory, Gérald, Farrow, Mark, Balasubramanian, Shankar
Telomeres are essential for genomic stability and cell viability. Telomerase, the enzyme responsible for telomere maintenance, is composed of a reverse transcriptase protein subunit and an integral...
Ren, Xiaojun, Gavory, Gérald, Li, Haitao, Ying, Liming, Klenerman, David, Balasubramanian, Shankar
The enzyme telomerase is a ribonucleoprotein that has a critical role in the maintenance of stable telomeres in organisms that possess linear chromosomes. Using a recently developed single molecule...
Ying, Liming, Green, Jeremy J., Li, Haitao, Klenerman, David, Balasubramanian, Shankar
We have investigated the structure and unfolding kinetics of the human telomeric intramolecular G quadruplex by using single-molecule fluorescence resonance energy transfer. An exploration of...
Li, Haitao, Ren, Xiaojun, Ying, Liming, Balasubramanian, Shankar, Klenerman, David
This work presents a general method for determining single-molecule intramolecular dynamics in biomolecules by using a reporter fluorophore, whose fluorescence is quenched or partially quenched as a...
Prevalence of quadruplexes in the human genome
Huppert, Julian L., Balasubramanian, Shankar
Guanine-rich DNA sequences of a particular form have the ability to fold into four-stranded structures called G-quadruplexes. In this paper, we present a working rule to predict which primary...
G-quadruplexes in promoters throughout the human genome
Huppert, Julian L., Balasubramanian, Shankar
Certain G-rich DNA sequences readily form four-stranded structures called G-quadruplexes. These sequence motifs are located in telomeres as a repeated unit, and elsewhere in the genome, where their...
G-quadruplexes: the beginning and end of UTRs
Huppert, Julian Leon, Bugaut, Anthony, Kumari, Sunita, Balasubramanian, Shankar
Molecular mechanisms that regulate gene expression can occur either before or after transcription. The information for post-transcriptional regulation can lie within the sequence or structure of the...
G-Quadruplex DNA Bound by a Synthetic Ligand is Highly Dynamic
Jena, Prakrit V., Shirude, Pravin S., Okumus, Burak, Laxmi-Reddy, Katta, Godde, Frédéric, Huc, Ivan, ...
Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression
Fernando, Himesh, Sewitz, Sven, Darot, Jeremy, Tavaré, Simon, Huppert, Julian Leon, Balasubramanian, Shankar
G-quadruplex nucleic acids have been proposed to play a role in a number of fundamental biological processes that include transcription and translation. We have developed a single-chain antibody that...