Shanmuga Sozhamannan

The Bacillus anthracischromosome contains four conserved, excision-proficient, putative prophages (2006)

Sozhamannan, Shanmuga, Chute, Michael D, McAfee, Farrell D, Fouts, Derrick E, Akmal, Arya, Galloway, Darrell R, ...

Abstract Background Bacillus anthracis is considered to be a recently emerged clone within the Bacillus cereus sensu lato group. The B. anthracis genome sequence contains four putative lambdoid...

Cloning and Sequencing of the Genes Downstream of the wbf Gene Cluster of Vibrio cholerae Serogroup O139 and Analysis of the Junction Genes in Other Serogroups

Sozhamannan, Shanmuga, Deng, Ying Kang, Li, Manrong, Sulakvelidze, Alexander, Kaper, James B., Johnson, Judith A., ...

The DNA sequence of the O-antigen biosynthesis cluster (wbf) of a recently emergent pathogen, Vibrio cholerae serogroup O139, has been determined. Here we report the sequence of the genes downstream...

Mutations in the Extracellular Protein Secretion Pathway Genes (eps) Interfere with Rugose Polysaccharide Production in and Motility of Vibrio cholerae

Ali, Afsar, Johnson, Judith A., Franco, Augusto A., Metzger, Daniel J., Connell, Terry D., Morris, J. Glenn, ...

Vibrio cholerae is the causal organism of the diarrheal disease cholera. The rugose variant of V. cholerae is associated with the secretion of an exopolysaccharide. The rugose polysaccharide has been...

Sequence Analysis of TnphoA Insertion Sites in Vibrio cholerae Mutants Defective in Rugose Polysaccharide Production

Ali, Afsar, Hayat Mahmud, Zahid, Morris, J. Glenn, Sozhamannan, Shanmuga, Johnson, Judith A.

Vibrio cholerae can switch from a smooth to a wrinkled or rugose colony phenotype characterized by the secretion of a polysaccharide that enables the bacteria to survive harsh environmental...

Phylogeny of Vibrio cholerae Based on recA Sequence

Stine, O. Colin, Sozhamannan, Shanmuga, Gou, Qing, Zheng, Siqen, Morris, J. Glenn, Johnson, Judith A.

We sequenced a 705-bp fragment of the recA gene from 113 Vibrio cholerae strains and closely related species. One hundred eighty-seven nucleotides were phylogenetically informative, 55 were...

Evidence for the Emergence of Non-O1 and Non-O139 Vibrio cholerae Strains with Pathogenic Potential by Exchange of O-Antigen Biosynthesis Regions

Li, Manrong, Shimada, Toshio, Morris, J. Glenn, Sulakvelidze, Alexander, Sozhamannan, Shanmuga

The novel epidemic strain Vibrio cholerae O139 Bengal originated from a seventh-pandemic O1 El Tor strain by antigenic shift resulting from homologous recombination-mediated exchange of O-antigen...

Comparative Genomic Analyses of the Vibrio Pathogenicity Island and Cholera Toxin Prophage Regions in Nonepidemic Serogroup Strains of Vibrio cholerae

Li, Manrong, Kotetishvili, Mamuka, Chen, Yuansha, Sozhamannan, Shanmuga

Two major virulence factors are associated with epidemic strains (O1 and O139 serogroups) of Vibrio cholerae: cholera toxin encoded by the ctxAB genes and toxin-coregulated pilus encoded by the tcpA...

Multilocus Sequence Typing Has Better Discriminatory Ability for Typing Vibrio cholerae than Does Pulsed-Field Gel Electrophoresis and Provides a Measure of Phylogenetic Relatedness

Kotetishvili, Mamuka, Stine, O. Colin, Chen, Yuansha, Kreger, Arnold, Sulakvelidze, Alexander, Sozhamannan, Shanmuga, ...

Twenty-two Vibrio cholerae isolates, including some from “epidemic” (O1 and O139) and “nonepidemic” serogroups, were characterized by pulsed-field gel electrophoresis (PFGE) and multilocus...

Cloning and Sequencing of the Genes Downstream of the wbf Gene Cluster of Vibrio cholerae Serogroup O139 and Analysis of the Junction Genes in Other Serogroups

Sozhamannan, Shanmuga, Deng, Ying Kang, Li, Manrong, Sulakvelidze, Alexander, Kaper, James B., Johnson, Judith A., ...

The DNA sequence of the O-antigen biosynthesis cluster (wbf) of a recently emergent pathogen, Vibrio cholerae serogroup O139, has been determined. Here we report the sequence of the genes downstream...

Mutations in the Extracellular Protein Secretion Pathway Genes (eps) Interfere with Rugose Polysaccharide Production in and Motility of Vibrio cholerae

Ali, Afsar, Johnson, Judith A., Franco, Augusto A., Metzger, Daniel J., Connell, Terry D., Morris, J. Glenn, ...

Vibrio cholerae is the causal organism of the diarrheal disease cholera. The rugose variant of V. cholerae is associated with the secretion of an exopolysaccharide. The rugose polysaccharide has been...

Sequence Analysis of TnphoA Insertion Sites in Vibrio cholerae Mutants Defective in Rugose Polysaccharide Production

Ali, Afsar, Hayat Mahmud, Zahid, Morris, J. Glenn, Sozhamannan, Shanmuga, Johnson, Judith A.

Vibrio cholerae can switch from a smooth to a wrinkled or rugose colony phenotype characterized by the secretion of a polysaccharide that enables the bacteria to survive harsh environmental...

Phylogeny of Vibrio cholerae Based on recA Sequence

Stine, O. Colin, Sozhamannan, Shanmuga, Gou, Qing, Zheng, Siqen, Morris, J. Glenn, Johnson, Judith A.

We sequenced a 705-bp fragment of the recA gene from 113 Vibrio cholerae strains and closely related species. One hundred eighty-seven nucleotides were phylogenetically informative, 55 were...

Evidence for the Emergence of Non-O1 and Non-O139 Vibrio cholerae Strains with Pathogenic Potential by Exchange of O-Antigen Biosynthesis Regions

Li, Manrong, Shimada, Toshio, Morris, J. Glenn, Sulakvelidze, Alexander, Sozhamannan, Shanmuga

The novel epidemic strain Vibrio cholerae O139 Bengal originated from a seventh-pandemic O1 El Tor strain by antigenic shift resulting from homologous recombination-mediated exchange of O-antigen...

Comparative Genomic Analyses of the Vibrio Pathogenicity Island and Cholera Toxin Prophage Regions in Nonepidemic Serogroup Strains of Vibrio cholerae

Li, Manrong, Kotetishvili, Mamuka, Chen, Yuansha, Sozhamannan, Shanmuga

Two major virulence factors are associated with epidemic strains (O1 and O139 serogroups) of Vibrio cholerae: cholera toxin encoded by the ctxAB genes and toxin-coregulated pilus encoded by the tcpA...

Multilocus Sequence Typing Has Better Discriminatory Ability for Typing Vibrio cholerae than Does Pulsed-Field Gel Electrophoresis and Provides a Measure of Phylogenetic Relatedness

Kotetishvili, Mamuka, Stine, O. Colin, Chen, Yuansha, Kreger, Arnold, Sulakvelidze, Alexander, Sozhamannan, Shanmuga, ...

Twenty-two Vibrio cholerae isolates, including some from “epidemic” (O1 and O139) and “nonepidemic” serogroups, were characterized by pulsed-field gel electrophoresis (PFGE) and multilocus...

RTX Toxin Actin Cross-Linking Activity in Clinical and Environmental Isolates of Vibrio cholerae▿

Cordero, Christina L., Sozhamannan, Shanmuga, Satchell, Karla J. Fullner

Vibrio cholerae strains from diverse O-antigen groups were evaluated for RTX toxin actin cross-linking activity. This study demonstrates that the actin cross-linking domain sequence is present within...

Molecular Characterization of a Variant of Bacillus anthracis-Specific Phage AP50 with Improved Bacteriolytic Activity▿ †

Sozhamannan, Shanmuga, McKinstry, Michael, Lentz, Shannon M., Jalasvuori, Matti, McAfee, Farrell, Smith, Angela, ...

The genome sequence of a Bacillus anthracis-specific clear plaque mutant phage, AP50c, contains 31 open reading frames spanning 14,398 bp, has two mutations compared to wild-type AP50t, and has a...