Qiao, Liya, Zhang, Huiyun, Wu, Shandong, He, Shaoheng
Abstract Background Protease-activated receptors (PAR) are seven transmembrane G-coupled receptors comprising four genes (PAR-1 ~ PAR-4). Mast cell has been identified to be able to express PARs and...
Yang, Haiwei, Wei, Jifu, Zhang, Huiyun, Lin, Liyan, Zhang, Wei, He, Shaoheng
Abstract Backgroud Recently, mast cells have been recognized to express several Toll-like receptors (TLRs) on their membrane surfaces, and granulocyte-macrophage colony-stimulating factor (GM-CSF)...
Experimental activation of mast cells and their pharmacological modulation. (2008)
He, Shaoheng, Walls, Andrew F.
The activation of mast cells is of pivotal importance in the pathogenesis of allergic conditions. Mast cell activation can provoke rapid increases in microvascular permeability, induce...
Wang, Li, Luo, Jianmin, He, Shaoheng
Abstract Background It has been recognized that dermal fibroblasts and matrix metalloproteases (MMP) play crucial roles in wound healing process in skin. Thrombin was found to stimulate IL-8 release...
Wang, Haiyan, Zheng, Yanshan, He, Shaoheng
Abstract Background Hypersecretion of cytokines and serine proteinases has been observed in asthma. Since protease-activated receptors (PARs) are receptors of several serine proteinases and airway...
He, Shaoheng, Aslam, Akhmed, Gaca, Marianna D., He, Yongsong, Buckley, Mark G., Hollenberg, Morley D., ...
Tryptase, the major secretory product of human mast cells, is emerging as a new target for therapeutic intervention in allergic airways disease. We have investigated the ability of tryptase and...
He, Shaoheng, McEuen, Alan R., Blewett, Sally A., Li, Ping, Buckley, Mark G., Leufkens, Paul, ...
Inhibitors of mast cell tryptase and chymase can be effective as mast cell stabilising compounds. Lactoferrin has been reported to inhibit tryptase activity, but its actions on other serine proteases...
The roles of chymase in acute allergic responses are not clear, despite the relative abundance of this serine proteinase in the secretory granules of human mast cells. We have isolated chymase to...