Chang, Edward F, Bao, Shaowen, Merzenich, Michael M
Experience-dependent plasticity during development results in the emergence of highly adapted representations of the external world in the adult brain. Previous studies have convincingly shown that...
Thesis (Ph. D.)--University of Southern California, 1999.
Impaired Eye-Blink Conditioning in waggler, a Mutant Mouse With Cerebellar BDNF Deficiency (1998)
Bao, Shaowen, Chen, Lu, Qiao, Xiaoxi, Knusel, Beat, Thompson, Richard F.
Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...
Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...
Chen, Lu, Bao, Shaowen, Qiao, Xiaoxi, Thompson, Richard F.
The waggler, a neurological mutant mouse with a disrupted putative neuronal Ca2+ channel γ subunit, exhibits a cerebellar granule cell-specific brain-derived neurotrophic factor deficit, severe...
Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice
Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...
Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...
Cerebellar cortical inhibition and classical eyeblink conditioning
Bao, Shaowen, Chen, Lu, Kim, Jeansok J., Thompson, Richard F.
The cerebellum is considered a brain structure in which memories for learned motor responses (e.g., conditioned eyeblink responses) are stored. Within the cerebellum, however, the relative importance...
Disruption of primary auditory cortex by synchronous auditory inputs during a critical period
Zhang, Li I., Bao, Shaowen, Merzenich, Michael M.
In the primary auditory cortex (AI), the development of tone frequency selectivity and tonotopic organization is influenced by patterns of neural activity. Introduction of synchronous inputs into the...
Suppression of cortical representation through backward conditioning
Bao, Shaowen, Chan, Vincent T., Zhang, Li I., Merzenich, Michael M.
Temporal stimulus reinforcement sequences have been shown to determine the directions of synaptic plasticity and behavioral learning. Here, we examined whether they also control the direction of...
Impaired Eye-Blink Conditioning in waggler, a Mutant Mouse With Cerebellar BDNF Deficiency
Bao, Shaowen, Chen, Lu, Qiao, Xiaoxi, Knusel, Beat, Thompson, Richard F.
In addition to their trophic functions, neurotrophins are also implicated in synaptic modulation and learning and memory. Although gene knockout techniques have been used widely in studying the roles...
Transgenic Brain-Derived Neurotrophic Factor Modulates a Developing Cerebellar Inhibitory Synapse
Bao, Shaowen, Chen, Lu, Qiao, Xiaoxi, Thompson, Richard F.
Brain-derived neurotrophic factor (BDNF) has been shown to promote synapse formation and maturation in neurons of many brain regions, including inhibitory synapses. In the cerebellum, the Golgi...
Development of spectral and temporal response selectivity in the auditory cortex
Chang, Edward F., Bao, Shaowen, Imaizumi, Kazuo, Schreiner, Christoph E., Merzenich, Michael M.
The mechanisms by which hearing selectivity is elaborated and refined in early development are very incompletely determined. In this study, we documented contributions of progressively maturing...
Chen, Lu, Bao, Shaowen, Qiao, Xiaoxi, Thompson, Richard F.
The waggler, a neurological mutant mouse with a disrupted putative neuronal Ca2+ channel γ subunit, exhibits a cerebellar granule cell-specific brain-derived neurotrophic factor deficit, severe...
Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice
Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...
Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...
Cerebellar cortical inhibition and classical eyeblink conditioning
Bao, Shaowen, Chen, Lu, Kim, Jeansok J., Thompson, Richard F.
The cerebellum is considered a brain structure in which memories for learned motor responses (e.g., conditioned eyeblink responses) are stored. Within the cerebellum, however, the relative importance...
Disruption of primary auditory cortex by synchronous auditory inputs during a critical period
Zhang, Li I., Bao, Shaowen, Merzenich, Michael M.
In the primary auditory cortex (AI), the development of tone frequency selectivity and tonotopic organization is influenced by patterns of neural activity. Introduction of synchronous inputs into the...
Suppression of cortical representation through backward conditioning
Bao, Shaowen, Chan, Vincent T., Zhang, Li I., Merzenich, Michael M.
Temporal stimulus reinforcement sequences have been shown to determine the directions of synaptic plasticity and behavioral learning. Here, we examined whether they also control the direction of...
Impaired Eye-Blink Conditioning in waggler, a Mutant Mouse With Cerebellar BDNF Deficiency
Bao, Shaowen, Chen, Lu, Qiao, Xiaoxi, Knusel, Beat, Thompson, Richard F.
In addition to their trophic functions, neurotrophins are also implicated in synaptic modulation and learning and memory. Although gene knockout techniques have been used widely in studying the roles...
Transgenic Brain-Derived Neurotrophic Factor Modulates a Developing Cerebellar Inhibitory Synapse
Bao, Shaowen, Chen, Lu, Qiao, Xiaoxi, Thompson, Richard F.
Brain-derived neurotrophic factor (BDNF) has been shown to promote synapse formation and maturation in neurons of many brain regions, including inhibitory synapses. In the cerebellum, the Golgi...
Development of spectral and temporal response selectivity in the auditory cortex
Chang, Edward F., Bao, Shaowen, Imaizumi, Kazuo, Schreiner, Christoph E., Merzenich, Michael M.
The mechanisms by which hearing selectivity is elaborated and refined in early development are very incompletely determined. In this study, we documented contributions of progressively maturing...
CLRN1 Is Nonessential in the Mouse Retina but Is Required for Cochlear Hair Cell Development
Geller, Scott F., Guerin, Karen I., Visel, Meike, Pham, Aaron, Lee, Edwin S., Dror, Amiel A., ...
Mutations in the CLRN1 gene cause Usher syndrome type 3 (USH3), a human disease characterized by progressive blindness and deafness. Clarin 1, the protein product of CLRN1, is a four-transmembrane...