BRCA-FA pathway as a target for anti-tumor drugs (2008)
Litman, Rachel, Gupta, Rigu, Brosh, Robert M., Cantor, Sharon B.
Promising research on DNA repair signaling pathways predicts a new age of anti-tumor drugs. This research was initiated through the discovery and characterization of proteins that functioned together...
Gupta, Rigu, Sharma, Sudha, Sommers, Joshua A., Kenny, Mark K., Cantor, Sharon B., Brosh, Robert M.
The BRCA1 associated C-terminal helicase (BACH1, designated FANCJ) is implicated in the chromosomal instability genetic disorder Fanconi anemia (FA) and hereditary breast cancer. A critical role of...
Peng, Min, Litman, Rachel, Xie, Jenny X., Sharma, Sudha, Brosh, Robert M., Cantor, Sharon B.
FANCJ also called BACH1/BRIP1 was first linked to hereditary breast cancer through its direct interaction with BRCA1. FANCJ was also recently identified as a Fanconi anemia (FA) gene product,...
Peng, Min, Litman, Rachel, Xie, Jenny X., Sharma, Sudha, Brosh, Robert M., Cantor, Sharon B.
FANCJ also called BACH1/BRIP1 was first linked to hereditary breast cancer through its direct interaction with BRCA1. FANCJ was also recently identified as a Fanconi anemia (FA) gene product,...
Gupta, Rigu, Sharma, Sudha, Doherty, Kevin M., Sommers, Joshua A., Cantor, Sharon B., Brosh, Robert M.
The BRCA1 associated C-terminal helicase (BACH1) associated with breast cancer has been implicated in double strand break (DSB) repair. More recently, BACH1 (FANCJ) has been genetically linked to the...
BACH1 is a DNA repair protein supporting BRCA1 damage response (2006)
Peng, Min, Litman, Rachel, Jin, Zhe, Fong, G., Cantor, Sharon B.
The link between defects in BRCA1 and breast cancer development may be best understood by deciphering the role of associated proteins. BRCA1 associated C-terminal helicase (BACH1) interacts directly...
Greenberg, Roger A., Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B., Nakatani, Yoshihiro, Livingston, David M.
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA...
Gupta, Rigu, Sharma, Sudha, Doherty, Kevin M., Sommers, Joshua A., Cantor, Sharon B., Brosh, Robert M.
The BRCA1 associated C-terminal helicase (BACH1) associated with breast cancer has been implicated in double strand break (DSB) repair. More recently, BACH1 (FANCJ) has been genetically linked to the...
Greenberg, Roger A., Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B., Nakatani, Yoshihiro, Livingston, David M.
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA...
Gupta, Rigu, Sharma, Sudha, Doherty, Kevin M., Sommers, Joshua A., Cantor, Sharon B., Brosh, Robert M.
The BRCA1 associated C-terminal helicase (BACH1) associated with breast cancer has been implicated in double strand break (DSB) repair. More recently, BACH1 (FANCJ) has been genetically linked to the...
Assessing the link between BACH1 and BRCA1 in the FA pathway (2005)
Cantor, Sharon B., Andreassen, Paul R.
The BACH1 helicase was initially identified by its direct binding to BRCA1 and, thus, was linked to hereditary breast cancer. More recently, BACH1 was identified as the gene defective in the J...
Litman, Rachel, Peng, Min, Jin, Zhe, Zhang, Fan, Zhang, Junran, Powell, Simon N., ...
We showed in this study that cells deficient of the BRCA1-associated BACH1 helicase, also known as BRIP1, failed to elicit homologous recombination (HR) after DNA double-stranded breaks (DSBs)....
Gupta, Rigu, Sharma, Sudha, Sommers, Joshua A., Jin, Zhe, Cantor, Sharon B., Brosh, Robert M.
We have investigated the DNA substrate specificity of BACH1 (BRCA1-associated C-terminal helicase). The importance of various DNA structural elements for efficient unwinding by purified recombinant...
Cantor, Sharon B., Drapkin, Ronny, Zhang, Fan, Lin, Yafang, Han, Juliana, Pamidi, Sushmita, ...
BACH1 is a nuclear protein that directly interacts with the highly conserved, C-terminal BRCT repeats of the tumor suppressor, BRCA1. Mutations within the BRCT repeats disrupt the interaction between...
Joo, Woo S., Jeffrey, Philip D., Cantor, Sharon B., Finnin, Michael S., Livingston, David M., Pavletich, Nikola P.
Cantor, Sharon B., Bell, Daphne W., Ganesan, Shridar, Kass, Elizabeth M., Drapkin, Ronny, Grossman, Steven R., ...
BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a mutation in a residue that...
BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway (1999)
Chen, Junjie, Silver, Daniel P., Cantor, Sharon B., Livingston, David M., Scully, Ralph
The two major hereditary breast cancer susceptibility genes, BRCA1 and BRCA2, are associated with early-onset breast and/or ovarian cancer and encode products that each interact with the product of...
Chen, Junjie, Silver, Daniel P., Walpita, Deepika, Cantor, Sharon B., Gazdar, Adi F., Tomlinson, Gail, ...
BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51. Results presented here show that BRCA1 and BRCA2...
Evidence for a Ras/Ral signaling cascade (1996)
Feig, Larry A., Urano, Takeshi, Cantor, Sharon B.
It is becoming clear that Ras proteins mediate their diverse biological functions by binding to, and participating in, the activation of multiple downstream targets. Recent work has identified...
Cantor, Sharon B., Urano, Takeshi, Feig, Larry A.
Ral proteins constitute a distinct family of Ras-related GTPases. Although similar to Ras in amino acid sequence, Ral proteins are activated by a unique nucleotide exchange factor and inactivated by...
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
Joo, Woo S., Jeffrey, Philip D., Cantor, Sharon B., Finnin, Michael S., Livingston, David M., Pavletich, Nikola P.
Brca1 C-terminal (BRCT) domains are a common protein–protein interaction motif in proteins involved in the DNA damage response and DNA repair. The DNA-damage response protein 53BP1 has two BRCT...
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
Greenberg, Roger A., Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B., Nakatani, Yoshihiro, Livingston, David M.
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA...
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
Joo, Woo S., Jeffrey, Philip D., Cantor, Sharon B., Finnin, Michael S., Livingston, David M., Pavletich, Nikola P.
Brca1 C-terminal (BRCT) domains are a common protein–protein interaction motif in proteins involved in the DNA damage response and DNA repair. The DNA-damage response protein 53BP1 has two BRCT...
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
Greenberg, Roger A., Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B., Nakatani, Yoshihiro, Livingston, David M.
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA...
Gupta, Rigu, Sharma, Sudha, Doherty, Kevin M., Sommers, Joshua A., Cantor, Sharon B., Brosh, Robert M.
The BRCA1 associated C-terminal helicase (BACH1) associated with breast cancer has been implicated in double strand break (DSB) repair. More recently, BACH1 (FANCJ) has been genetically linked to the...
The FANCJ/MutLα interaction is required for correction of the cross-link response in FA-J cells
Peng, Min, Litman, Rachel, Xie, Jenny, Sharma, Sudha, Brosh, Robert M, Cantor, Sharon B
FANCJ also called BACH1/BRIP1 was first linked to hereditary breast cancer through its direct interaction with BRCA1. FANCJ was also recently identified as a Fanconi anemia (FA) gene product,...
Gupta, Rigu, Sharma, Sudha, Sommers, Joshua A., Kenny, Mark K., Cantor, Sharon B., Brosh, Robert M.
The BRCA1 associated C-terminal helicase (BACH1, designated FANCJ) is implicated in the chromosomal instability genetic disorder Fanconi anemia (FA) and hereditary breast cancer. A critical role of...