Strategies to Reduce Mortality from Bacterial Sepsis in Adults in Developing Countries (2008)
Allen C. Cheng, T. Eoin West, Direk Limmathurotsakul, Sharon J. Peacock
Burkholderia pseudomalleigenome plasticity associated with genomic island variation (2008)
Tumapa, Sarinna, Holden, Matthew TG, Vesaratchavest, Mongkol, Wuthiekanun, Vanaporn, Limmathurotsakul, Direk, Chierakul, Wirongrong, ...
Abstract Background Burkholderia pseudomallei is a soil-dwelling saprophyte and the cause of melioidosis. Horizontal gene transfer contributes to the genetic diversity of this pathogen and may be an...
W. Joost Wiersinga, Catharina W. Wieland, Mark C. Dessing, Narisara Chantratita, Allen C. Cheng, Direk Limmathurotsakul, ...
BackgroundToll-like receptors (TLRs) are essential in host defense against pathogens by virtue of their capacity to detect microbes and initiate the immune response. TLR2 is seen as the most...
Tiyawisutsri, Rachaneeporn, Holden, Matthew TG, Tumapa, Sarinna, Rengpipat, Sirirat, Clarke, Simon R, Foster, Simon J, ...
Abstract Background The bacterial biothreat agents Burkholderia mallei and Burkholderia pseudomallei are the cause of glanders and melioidosis, respectively. Genomic and epidemiological studies have...
Tiyawisutsri, Rachaneeporn, Holden, Matthew TG, Tumapa, Sarinna, Rengpipat, Sirirat, Clarke, Simon R, Foster, Simon J, ...
Abstract Background The bacterial biothreat agents Burkholderia mallei and Burkholderia pseudomallei are the cause of glanders and melioidosis, respectively. Genomic and epidemiological studies have...
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)
Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...
Yes
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)
Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...
Yes
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)
Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...
Enright, Mark C., Day, Nicholas P. J., Davies, Catrin E., Peacock, Sharon J., Spratt, Brian G.
A multilocus sequence typing (MLST) scheme has been developed for Staphylococcus aureus. The sequences of internal fragments of seven housekeeping genes were obtained for 155 S. aureus isolates from...
Virulent Combinations of Adhesin and Toxin Genes in Natural Populations of Staphylococcus aureus
Peacock, Sharon J., Moore, Catrin E., Justice, Anita, Kantzanou, Maria, Story, Lisa, Mackie, Kathryn, ...
Most cases of severe Staphylococcus aureus disease cannot be explained by the action of a single virulence determinant, and it is likely that a number of factors act in combination during the...
Functional Blocking of Staphylococcus aureus Adhesins following Growth in Ex Vivo Media
Massey, Ruth C., Dissanayeke, Shobana R., Cameron, Brian, Ferguson, David, Foster, Timothy J., Peacock, Sharon J.
Defining the role of Staphylococcus aureus adhesins in disease pathogenesis may depend on the use of bacteria grown in culture media that more closely reflect the human milieu than conventional...
Determinants of Acquisition and Carriage of Staphylococcus aureus in Infancy
Peacock, Sharon J., Justice, Anita, Griffiths, D., Kantzanou, M. N., Crook, Derrick, ...
Nasal carriage of Staphylococcus aureus is a major risk factor for invasive S. aureus disease. The aim of this study was to define factors associated with carriage. We conducted a prospective,...
Holden, Matthew T. G., Feil, Edward J., Lindsay, Jodi A., Peacock, Sharon J., Day, Nicholas P. J., Enright, Mark C., ...
Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...
Wuthiekanun, Vanaporn, Amornchai, Premjit, Chierakul, Wirongrong, Cheng, Allen C., White, Nicholas J., Peacock, Sharon J., ...
An enzyme-linked immunosorbent assay-based rapid cassette immunoglobulin G (IgG) and IgM immunochromogenic test kit was compared to the indirect hemagglutination test (IHA) for the diagnosis of acute...
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei
Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...
Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...
Detection of Burkholderia pseudomallei in Soil within the Lao People's Democratic Republic
Wuthiekanun, Vanaporn, Mayxay, Mayfong, Chierakul, Wirongrong, Phetsouvanh, Rattanaphone, Cheng, Allen C., White, Nicholas J, ...
Clinical cases of melioidosis caused by the saprophyte Burkholderia pseudomallei were first noted in the Lao People's Democratic Republic (PDR) in 1999. In this study, 36% of 110 soil samples in...
Rapid Immunofluorescence Microscopy for Diagnosis of Melioidosis
Wuthiekanun, Vanaporn, Desakorn, Varunee, Wongsuvan, Gumphol, Amornchai, Premjit, Cheng, Allen C., Maharjan, Bina, ...
An immunofluorescent (IF) method that detects Burkholderia pseudomallei in clinical specimens within 10 min was devised. The results of this rapid method and those of an existing IF method were...
Role and Significance of Quantitative Urine Cultures in Diagnosis of Melioidosis
Limmathurotsakul, Direk, Wuthiekanun, Vanaporn, Chierakul, Wirongrong, Cheng, Allen C., Maharjan, Bina, Chaowagul, Wipada, ...
Melioidosis is associated with significant mortality in countries in which it is endemic. Previous studies have demonstrated that quantitative Burkholderia pseudomallei counts in blood are predictive...
Tiyawisutsri, Rachaneeporn, Peacock, Sharon J., Langa, Sayan, Limmathurotsakul, Direk, Cheng, Allen C., Chierakul, Wirongrong, ...
The indirect hemagglutination assay routinely used to detect antibodies to Burkholderia pseudomallei was modified to detect cross-reactivity of antibodies to B. pseudomallei, B. mallei, and B....
Peacock, Sharon J., Chieng, Grace, Cheng, Allen C., Dance, David A. B., Amornchai, Premjit, Wongsuvan, Gumphol, ...
Ashdown's medium, Burkholderia pseudomallei selective agar (BPSA), and a commercial Burkholderia cepacia medium were compared for their abilities to grow B. pseudomallei from 155 clinical specimens...
Chaowagul, Wipada, Chierakul, Wirongrong, Simpson, Andrew J., Short, Jennifer M., Stepniewska, Kasia, Maharjan, Bina, ...
Melioidosis (infection caused by Burkholderia pseudomallei) requires a prolonged course of oral antibiotics following initial intravenous therapy to reduce the risk of relapse after cessation of...
Maharjan, Bina, Chantratita, Narisara, Vesaratchavest, Mongkol, Cheng, Allen, Wuthiekanun, Vanaporn, Chierakul, Wirongrong, ...
Human melioidosis is associated with a high rate of recurrent disease, despite adequate antimicrobial treatment. Here, we define the rate of relapse versus the rate of reinfection in 116 patients...
Lindsay, Jodi A., Moore, Catrin E., Day, Nicholas P., Peacock, Sharon J., Witney, Adam A., Stabler, Richard A., ...
Staphylococcus aureus is the most common cause of hospital-acquired infection. In healthy hosts outside of the health care setting, S. aureus is a frequent colonizer of the human nose but rarely...
Wuthiekanun, Vanaporn, Chierakul, Wirongrong, Rattanalertnavee, Jurairat, Langa, Sayan, Sirodom, Damrong, Wattanawaitunechai, Charnkij, ...
A serological study was performed to determine recent human exposure to Burkholderia pseudomallei (the cause of melioidosis) in residents of southern Thailand affected by the tsunami of 26 December...
How Clonal Is Staphylococcus aureus?
Feil, Edward J., Cooper, Jessica E., Grundmann, Hajo, Robinson, D. Ashley, Enright, Mark C., Berendt, Tony, ...
Staphylococcus aureus is an important human pathogen and represents a growing public health burden owing to the emergence and spread of antibiotic-resistant clones, particularly within the hospital...
Cheng, Allen C., Wuthiekanun, Vanaporn, Limmathurosakul, Direk, Wongsuvan, Gumphol, Day, Nicholas P. J., Peacock, Sharon J.
Vesaratchavest, Mongkol, Tumapa, Sarinna, Day, Nicholas P. J., Wuthiekanun, Vanaporn, Chierakul, Wirongrong, Holden, Matthew T. G., ...
Burkholderia pseudomallei is a soil-dwelling saprophyte and the causative agent of melioidosis, a life-threatening human infection. Most cases are reported from northeast Thailand and northern...
Enright, Mark C., Day, Nicholas P. J., Davies, Catrin E., Peacock, Sharon J., Spratt, Brian G.
A multilocus sequence typing (MLST) scheme has been developed for Staphylococcus aureus. The sequences of internal fragments of seven housekeeping genes were obtained for 155 S. aureus isolates from...
Virulent Combinations of Adhesin and Toxin Genes in Natural Populations of Staphylococcus aureus
Peacock, Sharon J., Moore, Catrin E., Justice, Anita, Kantzanou, Maria, Story, Lisa, Mackie, Kathryn, ...
Most cases of severe Staphylococcus aureus disease cannot be explained by the action of a single virulence determinant, and it is likely that a number of factors act in combination during the...
Functional Blocking of Staphylococcus aureus Adhesins following Growth in Ex Vivo Media
Massey, Ruth C., Dissanayeke, Shobana R., Cameron, Brian, Ferguson, David, Foster, Timothy J., Peacock, Sharon J.
Defining the role of Staphylococcus aureus adhesins in disease pathogenesis may depend on the use of bacteria grown in culture media that more closely reflect the human milieu than conventional...
How Clonal Is Staphylococcus aureus?
Feil, Edward J., Cooper, Jessica E., Grundmann, Hajo, Robinson, D. Ashley, Enright, Mark C., Berendt, Tony, ...
Staphylococcus aureus is an important human pathogen and represents a growing public health burden owing to the emergence and spread of antibiotic-resistant clones, particularly within the hospital...
Determinants of Acquisition and Carriage of Staphylococcus aureus in Infancy
Peacock, Sharon J., Justice, Anita, Griffiths, D., Kantzanou, M. N., Crook, Derrick, ...
Nasal carriage of Staphylococcus aureus is a major risk factor for invasive S. aureus disease. The aim of this study was to define factors associated with carriage. We conducted a prospective,...
Holden, Matthew T. G., Feil, Edward J., Lindsay, Jodi A., Peacock, Sharon J., Day, Nicholas P. J., Enright, Mark C., ...
Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...
Wuthiekanun, Vanaporn, Amornchai, Premjit, Chierakul, Wirongrong, Cheng, Allen C., White, Nicholas J., Peacock, Sharon J., ...
An enzyme-linked immunosorbent assay-based rapid cassette immunoglobulin G (IgG) and IgM immunochromogenic test kit was compared to the indirect hemagglutination test (IHA) for the diagnosis of acute...
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei
Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...
Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...
Detection of Burkholderia pseudomallei in Soil within the Lao People's Democratic Republic
Wuthiekanun, Vanaporn, Mayxay, Mayfong, Chierakul, Wirongrong, Phetsouvanh, Rattanaphone, Cheng, Allen C., White, Nicholas J, ...
Clinical cases of melioidosis caused by the saprophyte Burkholderia pseudomallei were first noted in the Lao People's Democratic Republic (PDR) in 1999. In this study, 36% of 110 soil samples in...
Rapid Immunofluorescence Microscopy for Diagnosis of Melioidosis
Wuthiekanun, Vanaporn, Desakorn, Varunee, Wongsuvan, Gumphol, Amornchai, Premjit, Cheng, Allen C., Maharjan, Bina, ...
An immunofluorescent (IF) method that detects Burkholderia pseudomallei in clinical specimens within 10 min was devised. The results of this rapid method and those of an existing IF method were...
Role and Significance of Quantitative Urine Cultures in Diagnosis of Melioidosis
Limmathurotsakul, Direk, Wuthiekanun, Vanaporn, Chierakul, Wirongrong, Cheng, Allen C., Maharjan, Bina, Chaowagul, Wipada, ...
Melioidosis is associated with significant mortality in countries in which it is endemic. Previous studies have demonstrated that quantitative Burkholderia pseudomallei counts in blood are predictive...
Tiyawisutsri, Rachaneeporn, Peacock, Sharon J., Langa, Sayan, Limmathurotsakul, Direk, Cheng, Allen C., Chierakul, Wirongrong, ...
The indirect hemagglutination assay routinely used to detect antibodies to Burkholderia pseudomallei was modified to detect cross-reactivity of antibodies to B. pseudomallei, B. mallei, and B....
Peacock, Sharon J., Chieng, Grace, Cheng, Allen C., Dance, David A. B., Amornchai, Premjit, Wongsuvan, Gumphol, ...
Ashdown's medium, Burkholderia pseudomallei selective agar (BPSA), and a commercial Burkholderia cepacia medium were compared for their abilities to grow B. pseudomallei from 155 clinical specimens...
Chaowagul, Wipada, Chierakul, Wirongrong, Simpson, Andrew J., Short, Jennifer M., Stepniewska, Kasia, Maharjan, Bina, ...
Melioidosis (infection caused by Burkholderia pseudomallei) requires a prolonged course of oral antibiotics following initial intravenous therapy to reduce the risk of relapse after cessation of...
Maharjan, Bina, Chantratita, Narisara, Vesaratchavest, Mongkol, Cheng, Allen, Wuthiekanun, Vanaporn, Chierakul, Wirongrong, ...
Human melioidosis is associated with a high rate of recurrent disease, despite adequate antimicrobial treatment. Here, we define the rate of relapse versus the rate of reinfection in 116 patients...
Lindsay, Jodi A., Moore, Catrin E., Day, Nicholas P., Peacock, Sharon J., Witney, Adam A., Stabler, Richard A., ...
Staphylococcus aureus is the most common cause of hospital-acquired infection. In healthy hosts outside of the health care setting, S. aureus is a frequent colonizer of the human nose but rarely...
Wuthiekanun, Vanaporn, Chierakul, Wirongrong, Rattanalertnavee, Jurairat, Langa, Sayan, Sirodom, Damrong, Wattanawaitunechai, Charnkij, ...
A serological study was performed to determine recent human exposure to Burkholderia pseudomallei (the cause of melioidosis) in residents of southern Thailand affected by the tsunami of 26 December...
Cheng, Allen C., Wuthiekanun, Vanaporn, Limmathurosakul, Direk, Wongsuvan, Gumphol, Day, Nicholas P. J., Peacock, Sharon J.
Vesaratchavest, Mongkol, Tumapa, Sarinna, Day, Nicholas P. J., Wuthiekanun, Vanaporn, Chierakul, Wirongrong, Holden, Matthew T. G., ...
Burkholderia pseudomallei is a soil-dwelling saprophyte and the causative agent of melioidosis, a life-threatening human infection. Most cases are reported from northeast Thailand and northern...
Tiyawisutsri, Rachaneeporn, Holden, Matthew TG, Tumapa, Sarinna, Rengpipat, Sirirat, Clarke, Simon R, Foster, Simon J, ...
Chantratita, Narisara, Wuthiekanun, Vanaporn, Thanwisai, Aunchalee, Limmathurotsakul, Direk, Cheng, Allen C., Chierakul, Wirongrong, ...
Five enzyme-linked immunosorbent assays developed to detect antibodies to different Burkholderia pseudomallei antigen preparations were evaluated as diagnostic tests for melioidosis in northeast...
Biological Relevance of Colony Morphology and Phenotypic Switching by Burkholderia pseudomallei▿
Chantratita, Narisara, Wuthiekanun, Vanaporn, Boonbumrung, Khaemaporn, Tiyawisutsri, Rachaneeporn, Vesaratchavest, Mongkol, Limmathurotsakul, Direk, ...
Melioidosis is a notoriously protracted illness and is difficult to cure. We hypothesize that the causative organism, Burkholderia pseudomallei, undergoes a process of adaptation involving altered...
Improved Multilocus Sequence Typing Scheme for Staphylococcus epidermidis▿
Thomas, Jonathan C., Vargas, Miguel R., Miragaia, Maria, Peacock, Sharon J., Archer, Gordon L., Enright, Mark C.
We evaluated three multilocus sequence typing (MLST) schemes for Staphylococcus epidermidis and selected the seven most discriminatory loci for the formation of a new, more powerful MLST scheme. This...
Optimization of Culture of Leptospira from Humans with Leptospirosis▿
Wuthiekanun, Vanaporn, Chierakul, Wirongrong, Limmathurotsakul, Direk, Smythe, Lee D., Symonds, Meegan L., Dohnt, Michael F., ...
A prospective study of 989 patients with acute febrile illness was performed in northeast Thailand to define the yield of Leptospira from four different types of blood sample. Based on a comparison...
Wiersinga, W. Joost, Wieland, Catharina W, Dessing, Mark C, Chantratita, Narisara, Cheng, Allen C, Limmathurotsakul, Direk, ...
Willem Wiersinga and colleagues find up-regulation of multiple Toll-like receptors (TLRs) in peripheral blood cells of patients with melioidosis. However, only TLR2 had an effect on the immune...
Wiersinga, W. Joost, Dessing, Mark C., Kager, Piet A., Cheng, Allen C., Limmathurotsakul, Direk, Day, Nicholas P., ...
Sepsis is characterized by an uncontrolled inflammatory response to invading microorganisms. We describe the inflammatory mRNA profiles in whole-blood leukocytes, monocytes, and granulocytes using a...
Thaipadungpanit, Janjira, Wuthiekanun, Vanaporn, Chierakul, Wirongrong, Smythe, Lee D., Petkanchanapong, Wimol, Limpaiboon, Roongrueng, ...
A sustained outbreak of human leptospirosis occurred in northeast Thailand between 1999 and 2003, the basis for which was unknown. Leptospirosis is a potentially serious infection cause by bacteria...
Endogenous Interleukin-18 Improves the Early Antimicrobial Host Response in Severe Melioidosis▿
Wiersinga, W. Joost, Wieland, Catharina W., De Boer, Anita, Florquin, Sandrine, Dondorp, Arjen, ...
Melioidosis is caused by the soil saprophyte Burkholderia pseudomallei and is endemic in Southeast Asia. The pathogenesis of melioidosis is still largely unknown, although gamma interferon (IFN-γ)...
Doxycycline versus Azithromycin for Treatment of Leptospirosis and Scrub Typhus▿
Phimda, Kriangsak, Hoontrakul, Siriwan, Suttinont, Chuanpit, Chareonwat, Sompong, Losuwanaluk, Kitti, Chueasuwanchai, Sunee, ...
Leptospirosis and scrub typhus are important causes of acute fever in Southeast Asia. Options for empirical therapy include doxycycline and azithromycin, but it is unclear whether their efficacies...