Disease Gene Mapping in General (2009)
R. Browning, Li Li, Sharon R. Browning, Zhao-bang Zeng
Disease gene mapping is one of the main focuses of genetic epidemiology and statistical genetics. This dissertation explores some methods and algorithms in this area, especially in pedigrees. The...
Multilocus analysis of GAW15 NARAC chromosome 18 case-control data (2007)
Browning, Sharon R, Thomas, Jessica
Abstract The Genetic Analysis Workshop 15 rheumatoid arthritis data included a set of 460 cases and 460 controls genotyped at 2300 closely spaced markers on a 10 megabase region of chromosome 18q. We...
Sharon R. Browning, Linda P. Briley, Gyan Ch, Jonathan H. Charnecki, Margaret G. Ehm, ...
Related individuals collected for use in linkage studies may be used in case-control linkage disequilibrium analysis, provided one takes into account correlations between individuals due to...
Multilocus Association Mapping Using Variable-Length Markov Chains
I propose a new method for association-based gene mapping that makes powerful use of multilocus data, is computationally efficient, and is straightforward to apply over large genomic regions. The...
Multilocus Association Mapping Using Variable-Length Markov Chains
I propose a new method for association-based gene mapping that makes powerful use of multilocus data, is computationally efficient, and is straightforward to apply over large genomic regions. The...
Multilocus analysis of GAW15 NARAC chromosome 18 case-control data
Browning, Sharon R, Thomas, Jessica
The Genetic Analysis Workshop 15 rheumatoid arthritis data included a set of 460 cases and 460 controls genotyped at 2300 closely spaced markers on a 10 megabase region of chromosome 18q. We...
I present a new approach for calculating probabilities of identity by descent for pairs of haplotypes. The approach is based on a joint hidden Markov model for haplotype frequencies and identity by...
A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic
Madsen, Bo Eskerod, Browning, Sharon R.
Resequencing is an emerging tool for identification of rare disease-associated mutations. Rare mutations are difficult to tag with SNP genotyping, as genotyping studies are designed to detect common...
Browning, Brian L., Browning, Sharon R.
We present methods for imputing data for ungenotyped markers and for inferring haplotype phase in large data sets of unrelated individuals and parent-offspring trios. Our methods make use of known...