Sharon R. Grady

Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the α6 subtype (2009)

Breining, Scott R., Bencherif, Merouane, Grady, Sharon R., Whiteaker, Paul, Marks, Michael J., Wageman, Charles R., ...

Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands indicates that the pyrimidine substitution has the potential to enhance affinity and/or functional...

In vivo activation of midbrain dopamine neurons via sensitized, high-affinity α6*nicotinic acetylcholine receptors (2008)

Drenan, Ryan M., Grady, Sharon R., Whiteaker, Paul, McClure-Begley, Tristan, McKinney, Sheri, Miwa, Julie M., ...

α6-containing (α6*) nicotinic ACh receptors (nAChRs) are selectively expressed in dopamine (DA) neurons and participate in cholinergic transmission. We generated and studied mice with...

Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation (2007)

Whyte, Douglas, Cahir, Elizabeth, Lester, Henry A, Grady, Sharon R, Marks, Michael J, ...

We generated a mouse line harboring an autosomal-dominant nocturnal frontal lobe epilepsy (ADNFLE) mutation: the alpha 4 nicotinic receptor S248F knock-in strain. In this mouse, modest nicotine doses...

Pharmacological and Null Mutation Approaches Reveal Nicotinic Receptor Diversity (2000)

Paul Whiteaker, Michael J. Marks, Sharon R. Grady, Ying Lu, Marina R. Picciotto, Jean-Pierre Changeux, ...

w 125 x Z.w 3 x We have developed an array of assays for nicotinic acetylcholine receptor binding and function. I a-Bungarotoxin-, y - H nico- w 3 x tine-, and H epibatidine-binding nicotinic...

Two Pharmacologically Distinct Components of Nicotinic Receptor-Mediated Rubidium Efflux in Mouse Brain Require the (1999)

Subunit Michael Marks, Michael J. Marks, Paul Whiteaker, Jennifer Calcaterra, Jerry A. Stitzel, Amy E. Bullock, ...

Nicotinic agonist-stimulated efflux of 86 Rb 1 from mouse brain synaptosomes was monitored continuously by on-line radioactivity detection. The concentration-effect curve following a 5-s stimulation...

Tritium exchange reactions catalyzed by 2-oxo-4-hydroxyglutarate aldolase from Escherichia coli K-12 (1979)

Grady, Sharon R., Dekker, Eugene E.

Tritiated water and tritiated substrates have been used to study exchange reactions catalyzed by Escherichia coli 2-oxo-4-hydroxyglutarate aldolase (4-hydroxy-2-oxoglutarate glyoxylate-lyase, EC...