Alcoholic hepatitis is a serious consequence of alcohol misuse and the usual precursor of cirrhosis. Risk factors, histology, pathogenesis, clinical features, prognosis and treatment are discussed in...
BURROUGHS, A. K., MORGAN, MARSHA Y., SHERLOCK, SHEILA
Seventy-one patients undergoing withdrawal from alcohol were randomly assigned to treatment with oral bromocriptine, chlormethiazole or chlordiazepoxide. Forty-one percent had alcoholic hepatitis...
CURRENT PROBLEMS IN ALCOHOLIC LIVER DISEASE (1983)
The development of alcohol-related liver injury is reviewed. Factors predisposing to an individual's susceptibility to cirrhosis are considered and the possible mechanisms by which alcohol might...
MORGAN, MARSHA Y, COLMAN, JOHN C, SHERLOCK, SHEILA
Values for serum aspartate transaminase, gamma glutamyl transpeptidase and mean corpuscular volume were followed in twenty actively drinking alcoholics with pre-cirrhotic liver disease over a...
The Aetiology, Presentation and Natural History of Extra-hepatic Portal Venous Obstruction (1979)
WEBB, LINDSAY J., SHERLOCK, SHEILA
Extra-hepatic obstruction of the portal vein is a well known cause of hypertension in childhood and 55 out of the 97 patients (57 per cent) seen with this condition presented before they were 15...
Trial of ribavirin for the treatment of HBsAg positive chronic liver disease (1978)
Jain, S., Thomas, H. C., Oxford, J. S., Sherlock, Sheila
Six patients with HBsAg positive chronic liver disease were treated with ribavirin, a nucleoside analogue, in a double-blind controlled trial. Serum aspartate transaminase levels and hepatitis B...
KENNEDY, JEAN, PARBHOO, S. P., MACGILLIVRAY, B., SHERLOCK, SHEILA
The electroencephalogram (EEG) has been used in the assessment and selection of patients in coma due to acute liver failure for extracorporeal pig-liver perfusion. The response during and following...
Controlled Prospective Trial of Corticosteroid Therapy in Active Chronic Hepatitis (1971)
COOK, G. C., MULLIGAN, ROSEMARY, SHERLOCK, SHEILA
By a method using sealed envelopes a series of patients with active chronic hepatitis who had not received corticosteroids or adrenocorticotrophic hormone was divided into two groups; one was given...
CARCINOMA AT THE JUNCTION OF THE MAIN HEPATIC DUCTS (1969)
WHELTON, M. J., PETRELLI, MARY, GEORGE, PHYLLIS, YOUNG, W. B., SHERLOCK, SHEILA
IRON ABSORPTION AND SIDEROSIS IN CHRONIC LIVER DISEASE (1967)
WILLIAMS, ROGER, WILLIAMS, H.S., SCHEUER, P.J., PITCHER, C.S., LOISEAU, E., SHERLOCK, SHEILA
Cirugía de la vesícula y vías biliares / por Rodney Smith y Sheila Sherlock (1966)
Smith, Rodney, Sherlock, Sheila
Traducción de: Surgery of the Gall Bladder and bile ducts
ULCERATIVE COLITIS IN CHRONIC LIVER DISEASE (1965)
HOLDSWORTH, C. D., HALL, ELIZABETH W., DAWSON, A. M., SHERLOCK, SHEILA
AMMONIUM TOLERANCE IN LIVER DISEASE: OBSERVATIONS BASED ON CATHETERIZATION OF THE HEPATIC VEINS
White, Laurens P., Phear, Elizabeth A., Summerskill, W. H. J., Sherlock, Sheila, Cole, Marjorie
Renal involvement in active `juvenile' cirrhosis
Silva, Homero, Hall, Elizabeth W., Hill, Kenneth R., Shaldon, Stanley, Sherlock, Sheila
Twelve patients with active `juvenile' cirrhosis (active chronic hepatitis, `lupoid' hepatitis) and six subjects with other types of portal or postnecrotic cirrhosis were submitted to percutaneous...
Haemagglutination in acute hepatitis and other diseases
Turner, Paul, Jha, V. N., Crowley, Nuala, Sherlock, Sheila
A haemagglutination test using day-old chick erythrocytes was applied to the sera of 210 patients with hepato-biliary disease and to those of 31 with other diseases.
Hepatic blood flow and carbohydrate changes in man during fainting
Bearn, A. G., Billing, Barbara, Edholm, O. G., Sherlock, Sheila
A Controlled Trial of D-penicillamine Therapy in Primary Biliary Cirrhosis [Abstract]
Jain, Stephen, Scheuer, P J, Samourian, S, McGee, J O'D, Sherlock, Sheila
Fibrinolysis in Cholestatic Jaundice
Jedrychowski, A., Hillenbrand, P., Ajdukiewicz, A. B., Parbhoo, S. P., Sherlock, Sheila
The fibrinolytic system was studied in primary biliary cirrhosis (16 patients) and large bile duct obstruction (10 patients, nine of whom had carcinoma). Plasma fibrinolysis (plasminogen activator...
AMMONIUM TOLERANCE IN LIVER DISEASE: OBSERVATIONS BASED ON CATHETERIZATION OF THE HEPATIC VEINS
White, Laurens P., Phear, Elizabeth A., Summerskill, W. H. J., Sherlock, Sheila, Cole, Marjorie
Renal involvement in active `juvenile' cirrhosis
Silva, Homero, Hall, Elizabeth W., Hill, Kenneth R., Shaldon, Stanley, Sherlock, Sheila
Twelve patients with active `juvenile' cirrhosis (active chronic hepatitis, `lupoid' hepatitis) and six subjects with other types of portal or postnecrotic cirrhosis were submitted to percutaneous...
Haemagglutination in acute hepatitis and other diseases
Turner, Paul, Jha, V. N., Crowley, Nuala, Sherlock, Sheila
A haemagglutination test using day-old chick erythrocytes was applied to the sera of 210 patients with hepato-biliary disease and to those of 31 with other diseases.
Hepatic blood flow and carbohydrate changes in man during fainting
Bearn, A. G., Billing, Barbara, Edholm, O. G., Sherlock, Sheila
A Controlled Trial of D-penicillamine Therapy in Primary Biliary Cirrhosis [Abstract]
Jain, Stephen, Scheuer, P J, Samourian, S, McGee, J O'D, Sherlock, Sheila
Fibrinolysis in Cholestatic Jaundice
Jedrychowski, A., Hillenbrand, P., Ajdukiewicz, A. B., Parbhoo, S. P., Sherlock, Sheila
The fibrinolytic system was studied in primary biliary cirrhosis (16 patients) and large bile duct obstruction (10 patients, nine of whom had carcinoma). Plasma fibrinolysis (plasminogen activator...
Diagnosis of Primary Cancer of the Liver
Kew, M. C., Dos Santos, H. A., Sherlock, Sheila
The diagnosis of primary cancer of the liver was reviewed in 75 patients. A definitive diagnosis was made during life in 63% and in a further 20% this condition was suspected though histological...
Use of Metolazone in the Treatment of Ascites due to Liver Disease
Hillenbrand, P., Sherlock, Sheila
In 8 out of 20 patients with chronic liver disease ascites was controlled with metolazone, 10 required additional amiloride or spironolactone to achieve control, and 2 were resistant to all diuretic...
Elective End-to-side Portacaval Shunt: Results in 64 Cases
Hourigan, K., Sherlock, Sheila, George, Phyllis, Mindel, S.
In a series of 64 cases of elective end-to-side portacaval shunts performed for liver disease the success rate—in that the patient survived with a patent shunt, free of subsequent haemorrhage and...
The serum concentration of the third component of complement β1C/β1A in liver disease
Fox, R. A., Dudley, F. J., Sherlock, Sheila
Serum C3 (β1C/β1A) has been measured in normal individuals and the range found is in agreement with findings of other authors (85-370 mg/100 ml). In 18 patients with acute hepatitis and massive...
47Calcium absorption in parenchymatous and biliary liver disease
Whelton, Michael J., Kehayoglou, A. K., Agnew, J. E., Turnberg, L. A., Sherlock, Sheila
As measured by whole body retention of isotopic calcium given in milk, absorption of calcium was impaired in 10 patients with chronic parenchymal non-biliary liver disease who were icteric. Mean...
The effect of octapressin on renal and intrarenal blood flow in cirrhosis of the liver 1
Kew, M. C., Varma, R. R., Sampson, D. J., Sherlock, Sheila
The effect of octapressin (2-phenylalanine-8-lysine vasopressin) on renal and intrarenal blood flow was studied in 11 normotensive cirrhotic patients with abnormal renal perfusion. Renal haemodynamic...
Renal blood flow in malignant disease of the liver
Kew, M. C., Limbrick, Carol A., Varma, R. R., Sherlock, Sheila
Although functional renal failure has been reported in patients with malignant disease of the liver, renal haemodynamics and function have not been investigated. Renal and intrarenal blood flow was...
Whelan, Gregory, Sherlock, Sheila
The rosette inhibition test was used to measure serum immunosuppressive activity after azathioprine (1·5 mg/kg) in 20 patients with liver disease (10 with active chronic hepatitis, six with primary...
Renal and intrarenal blood flow in non-cirrhotic portal hypertension
Kew, M. C., Limbrick, Carol, Varma, R. R., Sherlock, Sheila
The effect of portal hypertension or the consequent portal circulatory changes on renal haemodynamics was studied using the 133xenon washout technique. Renal blood flow was reduced in nine of 11...
Fox, R. A., Dudley, F. J., Samuels, M., Milligan, J., Sherlock, Sheila
The aim of this study was to determine the importance of plasma inhibitory factors in producing the impaired phytohaemagglutinin (PHA)-induced lymphocyte transformation that is seen in some patients...
Skeletal muscle blood flow and neurovascular reactivity in liver disease 1
Lunzer, Michael, Newman, S. P., Sherlock, Sheila
There was no significant difference in forearm muscle blood flow, measured by the clearance of 133Xenon when 38 patients with liver disease were compared with 38 normal subjects. Patients with a...
Asymptomatic primary biliary cirrhosis
Fox, R. A., Scheuer, P. J., Sherlock, Sheila
Four asymptomatic patients are described with raised serum alkaline phosphatase values and a positive serum mitochondrial antibody test. In all four needle liver biopsy showed destructive bile duct...
Significance of intravascular coagulation and fibrinolysis in acute hepatic failure
Hillenbrand, P., Parbhoo, S. P., Jedrychowski, A., Sherlock, Sheila
Twenty-two patients with acute hepatic failure were studied to determine the incidence and magnitude of intravascular coagulation and fibrinolysis and their relation to the severity of bleeding and...
67Gallium scanning in the diagnosis of liver disease
James, Oliver, Wood, E. J., Sherlock, Sheila
67Gallium (67Ga) citrate liver scanning has been carried out on 60 selected patients following a scan with a radioactive colloid preparation.
Brunt, P. W., Kew, M. C., Scheuer, P. J., Sherlock, Sheila
A group of 258 patients with various forms of alcoholic liver disease—steatosis, mild and severe hepatitis, and cirrhosis—has been studied. Severity of disease as judged histologically did not...
Treatment of chronic hepatic encephalopathy with levodopa 1
Lunzer, Michael, James, I. M., Weinman, J., Sherlock, Sheila
Three of six patients with chronic hepatic encephalopathy treated with levodopa showed a significant improvement. One patient was probably improved whilst the remaining two patients failed to show...
The relief of bone pain in primary biliary cirrhosis with calcium infusions
Ajdukiewicz, A. B., Agnew, J. E., Byers, P. D., Wills, M. R., Sherlock, Sheila
Intravenous calcium infusions produced subjective relief of bone pain in 14 patients with primary biliary cirrhosis. The bone pain had developed despite long-term parenteral vitamin D therapy. The...
Post-necrotic cirrhosis with chronic cholestasis
Datta, D. V., Sherlock, Sheila, Scheuer, Peter J.
Features of biliary obstruction were seen in 57 of 300 cases of post-necrotic cirrhosis but gave rise to real diagnostic difficulty in only 11 cases. The paper deals with the recognition and possible...
Read, A. E., Sherlock, Sheila, Harrison, C. V.
This is a clinical study of 81 patients (32 male and 49 female), who are not alcoholics, with jaundice of hepato-cellular type lasting longer than three months. Forty-nine of these patients were...
Differential ferrioxamide test in haemochromatosis and liver disease
Barry, Michael, Cartei, Guiseppe, Sherlock, Sheila
The effect of desferrioxamine is examined in more than 100 patients with liver disease, including haemochromatosis, using the differential ferrioxamine test.
Measurement of iron stores in cirrhosis using diethylenetriamine penta-acetic acid
Barry, Michael, Cartei, Guiseppe, Sherlock, Sheila
The chelating agent diethylenetriamine penta-acetic acid was used to measure iron stores in 83 patients with chronic liver disease. Iron chelation was normal in patients with chronic cholestasis....
Quantitative measurement of iron stores with diethylenetriamine penta-acetic acid
Barry, Michael, Cartei, Guiseppe, Sherlock, Sheila
The use of the chelating agent diethylenetriamine penta-acetic acid (DTPA) for measuring body storage iron was investigated in patients with iron excess whose stores could be determined by...
The primary immune response to haemocyanin in patients with primary biliary cirrhosis
Fox, R. A., Dudley, F. J., Sherlock, Sheila
Both the humoral and cellular immune response to haemocyanin was measured in normal subjects and patients with liver disease including primary biliary cirrhosis, other forms of cholestasis, and...
Immunoglobulin-containing cells in the liver
Hadziyannis, S., Feizi, Ten, Scheuer, P. J., Sherlock, Sheila
Liver samples from sixty-four patients with hepato-biliary diseases, and from twenty-three with miscellaneous (primarily non-hepatic) conditions, were examined by the fluorescent antibody technique...
Doniach, Deborah, Roitt, I. M., Walker, J. G., Sherlock, Sheila
The sera of virtually all patients with primary biliary cirrhosis contained non-organ specific antibodies, probably directed against mitochondria, which give rise to cytoplasmic `M'...
Bleeding Oesophageal Varices Treated by Oesophageal Compression Tube
Read, A. E., Dawson, A. M., Kerr, D. N. S., Turner, M. D., Sherlock, Sheila
Chronic Cholangitides: Aetiology, Diagnosis, and Treatment*
A number of different chronic diseases affect the intrahepatic bile radicles or cholangioles. They include primary and secondary sclerosing cholangitis, primary biliary cirrhosis, chronic cholestatic...
Cyanosis with hepatic cirrhosis: A case with pulmonary arteriovenous shunting
Karlish, A. J., Marshall, R., Reid, Lynne, Sherlock, Sheila
A case is reported of cirrhosis of the liver associated with cyanosis and finger clubbing in a man of 31 years. The chest radiograph showed diffuse nodular shadows in both lower zones. Pulmonary...
The management of acute hepatic failure
Sherlock, Sheila, Parbhoo, S. P.
Acute fulminant hepatitis leads to complex biochemical and circulatory disturbances including coma. These can be predicted to some extent by knowledge of the functions of the normal liver cells....