Novobrantseva, Tatiana, Xu, Shengli, Tan, Joy En-Lin, Maruyama, Mitsuo, Schwers, Stephan, Pelanda, Roberta, ...
We examined the generation and selection of the B cell antibody repertoire through crossing of mice bearing distinct Ig heavy (H) and light (L) chain rearranged variable region transgenes. Ig gene...
Novobrantseva, Tatiana, Xu, Shengli, Tan, Joy En-Lin, Maruyama, Mitsuo, Schwers, Stephan, Pelanda, Roberta, ...
We examined the generation and selection of the B cell antibody repertoire through crossing of mice bearing distinct Ig heavy (H) and light (L) chain rearranged variable region transgenes. Ig gene...
Xu, Shengli, Tan, Joy En-Lin, Wong, Esther Poh-Ying, Manickam, Arunkumar, Ponniah, Sathivel, Lam, Kong-Peng
Engagement of the B cell receptor (BCR) leads to the activation of tyrosine kinases and other signaling molecules that ultimately determine the type and magnitude of the B lymphocyte's cellular...
B-cell maturation protein (BCMA) is a member of the tumor necrosis factor (TNF) receptor family and is expressed in B lymphocytes. BCMA binds two TNF family members, BAFF and APRIL, that stimulate...
Cbp Deficiency Alters Csk Localization in Lipid Rafts but Does Not Affect T-Cell Development
Xu, Shengli, Huo, Jianxin, Tan, Joy En-Lin, Lam, Kong-Peng
The ubiquitously expressed transmembrane adaptor Csk-binding protein (Cbp) recruits Csk to lipid rafts, where the latter exerts its negative regulatory effect on the Src family of protein tyrosine...
B-cell maturation protein (BCMA) is a member of the tumor necrosis factor (TNF) receptor family and is expressed in B lymphocytes. BCMA binds two TNF family members, BAFF and APRIL, that stimulate...
Cbp Deficiency Alters Csk Localization in Lipid Rafts but Does Not Affect T-Cell Development
Xu, Shengli, Huo, Jianxin, Tan, Joy En-Lin, Lam, Kong-Peng
The ubiquitously expressed transmembrane adaptor Csk-binding protein (Cbp) recruits Csk to lipid rafts, where the latter exerts its negative regulatory effect on the Src family of protein tyrosine...
TACI and BAFF-R mediate isotype switching in B cells
Castigli, Emanuela, Wilson, Stephen A., Scott, Sumi, Dedeoglu, Fatma, Xu, Shengli, Lam, Kong-Peng, ...
The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1,...
B cell linker (BLNK) protein is a component of the B cell receptor (BCR) signaling pathway and BLNK−/− mice have a block in B lymphopoiesis at the pro-B/pre-B cell stage. To study the effect of...