Samuelsson, Martin, Jendholm, Johan, Amisten, Stefan, Morrison, Sherie L, Forsgren, Arne, Riesbeck, Kristian
Abstract is not available
Wright, Ann, Sato, Yuji, Okada, Toyohiro, Chang, Kern Hee, Endo, Tamao, Morrison, Sherie L.
We have now produced mouse–human chimeric IgG1 in wild-type Chinese hamster ovary (CHO) cell lines Pro-5 as well as in the glycosylation mutants Lec 2, Lec 8, and Lec 1. Analysis of the attached...
Chapman, Tara L., You, Il, Joseph, Ian M., Bjorkman, Pamela J., Morrison, Sherie L., Raghavan, Malini
Herpes simplex virus type I (HSV-1) virions and HSV-1-infected cells bind to human immunoglobulin G (hIgG) via its Fc region. A complex of two surface glycoproteins encoded by HSV-1, gE and gI, is...
Ward, Susan B., Morrison, Sherie L.
The cell line G403.4.7, isolated as a spontaneous variant of the MPC-11 derived myeloma G403.4, produces a truncated γ2b HC protein, but no light chain (LC), and a single γ2b specific transcript of...
Anderson, Michael T., Wims, Letitia A., Morrison, Sherie L.
In mature B cells the nuclear factor NF-×B which binds within the kappa enhancer is constitutively present In the nucleus. However, the λ light chain producing myeloma J558L has k e n found to lack...
Production of secretory immunoglobulin A by a single mammalian cell
Chintalacharuvu, Koteswara R., Morrison, Sherie L.
Secretory IgA (sIgA) plays a critical role in providing protection against infection at the mucosal surfaces. Normally, sIgA is the product of two different cell types with heavy, light, and J chains...
Guan, Lufeng, Wims, Letitia A., Kane, Robert R., Smuckler, Mark B., Morrison, Sherie L., Hawthorne, M. Frederick
The application of immunoprotein-based targeting strategies to the boron neutron-capture therapy of cancer poses an exceptional challenge, because viable boron neutron-capture therapy by this method...
Ng, Patrick P., Dela Cruz, Jay S., Sorour, David N., Stinebaugh, James M., Shin, Seung-Uon, Shin, Daniel S., ...
We have developed an antibody fusion protein (anti-rat TfR IgG3-Av) with the ability to deliver different molecules into cancer cells. It consists of avidin genetically fused to the CH3 region of a...
Chintalacharuvu, Koteswara R., Chuang, Philip D., Dragoman, Ashley, Fernandez, Christine Z., Qiu, Jiazhou, Plaut, Andrew G., ...
Secretory immunoglobulin A (IgA) protects the mucosal surfaces against inhaled and ingested pathogens. Many pathogenic bacteria produce IgA1 proteases that cleave in the hinge of IgA1, thus...
Targeting of functional antibody-CD59 fusion proteins to a cell surface
Zhang, Hui-fen, Yu, Jinghua, Bajwa, Ednan, Morrison, Sherie L., Tomlinson, Stephen
Complement is involved in the pathogenesis of many diseases, and there is great interest in developing inhibitors of complement for therapeutic application. CD59 is a natural membrane-bound inhibitor...
Characterization of the J Chain from Polymeric Immunoglobulins
Morrison, Sherie L., Koshland, Marian Elliott
The J chains isolated from polymeric IgA and IgM were shown to be distinct from the other immunoglobulin subunits, including the secretory component, both on the basis of amino-acid content and...
Production of secretory immunoglobulin A by a single mammalian cell
Chintalacharuvu, Koteswara R., Morrison, Sherie L.
Secretory IgA (sIgA) plays a critical role in providing protection against infection at the mucosal surfaces. Normally, sIgA is the product of two different cell types with heavy, light, and J chains...
Guan, Lufeng, Wims, Letitia A., Kane, Robert R., Smuckler, Mark B., Morrison, Sherie L., Hawthorne, M. Frederick
The application of immunoprotein-based targeting strategies to the boron neutron-capture therapy of cancer poses an exceptional challenge, because viable boron neutron-capture therapy by this method...
Ng, Patrick P., Dela Cruz, Jay S., Sorour, David N., Stinebaugh, James M., Shin, Seung-Uon, Shin, Daniel S., ...
We have developed an antibody fusion protein (anti-rat TfR IgG3-Av) with the ability to deliver different molecules into cancer cells. It consists of avidin genetically fused to the CH3 region of a...
Chintalacharuvu, Koteswara R., Chuang, Philip D., Dragoman, Ashley, Fernandez, Christine Z., Qiu, Jiazhou, Plaut, Andrew G., ...
Secretory immunoglobulin A (IgA) protects the mucosal surfaces against inhaled and ingested pathogens. Many pathogenic bacteria produce IgA1 proteases that cleave in the hinge of IgA1, thus...
Targeting of functional antibody-CD59 fusion proteins to a cell surface
Zhang, Hui-fen, Yu, Jinghua, Bajwa, Ednan, Morrison, Sherie L., Tomlinson, Stephen
Complement is involved in the pathogenesis of many diseases, and there is great interest in developing inhibitors of complement for therapeutic application. CD59 is a natural membrane-bound inhibitor...
Characterization of the J Chain from Polymeric Immunoglobulins
Morrison, Sherie L., Koshland, Marian Elliott
The J chains isolated from polymeric IgA and IgM were shown to be distinct from the other immunoglobulin subunits, including the secretory component, both on the basis of amino-acid content and...
Beenhouwer, David O., Yoo, Esther M., Lai, Chun-Wei, Rocha, Miguel A., Morrison, Sherie L.
The encapsulated yeast Cryptococcus neoformans is a significant cause of meningitis and death in patients with AIDS. Some murine monoclonal antibodies (MAbs) against the glucuronoxylomannan (GXM)...
Ng, Patrick P., Helguera, Gustavo, Daniels, Tracy R., Lomas, Simon Z., Rodriguez, Jose A., Schiller, Gary, ...
We have previously reported that an anti-human transferrin receptor IgG3-avidin fusion protein (anti-hTfR IgG3-Av) inhibits the proliferation of an erythroleukemia-cell line. We have now found that...
Rifai, Abdalla, Fadden, Kim, Morrison, Sherie L., Chintalacharuvu, Koteswara R.
Human immunoglobulin (Ig)A exists in blood as two isotypes, IgA1 and IgA2, with IgA2 present as three allotypes: IgA2m(1), IgA2m(2), and IgA2m(n). We now demonstrate that recombinant, chimeric IgA1...
Role of Complement in Protection against Cryptococcus gattii Infection▿
Mershon, Kileen L., Vasuthasawat, Alex, Lawson, Gregory W., Morrison, Sherie L., Beenhouwer, David O.
Previous studies have shown that the alternative pathway of complement activation plays an important role in protection against infection with Cryptococcus neoformans. Cryptococcus gattii does not...