Kim, Caroline S., Ying, Hao, Willingham, Mark C., Cheng, Sheue-yann
Overexpression of the pituitary tumor-transforming gene (PTTG) has been associated with tumorigenesis. In a mouse model that spontaneously develops follicular thyroid cancer (FTC) with distant...
Furuya, Fumihiko, Lu, Changxue, Willingham, Mark C., Cheng, Sheue-yann
Aberrant activation of the phosphatidylinositol 3-kinase (PI3K)–AKT/protein kinase B-signaling pathway has been associated with multiple human cancers, including thyroid cancer. Recently, we showed...
Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance (2004)
Miller, Lance D, McPhie, Peter, Suzuki, Hideyo, Kato, Yasuhito, Liu, Edison T, Cheng, Sheue-yann
Abstract Background Resistance to thyroid hormone (RTH) is caused by mutations of the thyroid hormone receptor β (TRβ) gene. To understand the transcriptional program underlying TRβ mutant-induced...
Ying, Hao, Suzuki, Hideyo, Furumoto, Hiroko, Walker, Robert, Meltzer, Paul, Willingham, Mark C., ...
The molecular genetics underlying thyroid carcinogenesis is not well understood. We have recently created a mutant mouse by targeting a mutation (PV) into the thyroid hormone receptor β gene (TRβPV...
Ying, Hao, Suzuki, Hideyo, Furumoto, Hiroko, Walker, Robert, Meltzer, Paul, Willingham, Mark C., ...
The molecular genetics underlying thyroid carcinogenesis is not well understood. We have recently created a mutant mouse by targeting a mutation (PV) into the thyroid hormone receptor β gene (TRβPV...
Ying, Hao, Suzuki, Hideyo, Furumoto, Hiroko, Walker, Robert, Meltzer, Paul, Willingham, Mark C., ...
The molecular genetics underlying thyroid carcinogenesis is not well understood. We have recently created a mutant mouse by targeting a mutation (PV) into the thyroid hormone receptor β gene (TRβPV...
Kamiya, Yuji, Puzianowska-Kuznicka, Monika, McPhie, Peter, Nauman, Janusz, Cheng, Sheue-yann, Nauman, Alicja
Thyroid hormone (T3) regulates proliferation and differentiation of cells, via its nuclear receptors (TRs). These processes have been shown to be abnormally regulated during carcinogenesis. We have...
McDonald, Michael P., Wong, Rosemary, Goldstein, Gregory, Weintraub, Bruce, Cheng, Sheue-yann, Crawley, Jacqueline N.
Cheng, Sheue-Yann, Merlino, Glenn T., Pastan, H.
We describe a simple, general method to link proteins covalently to ONA. The method uses two reagents, N-acetyl-N'-(p-glyoxylylbenzoyl)cystam1ne and 2-1m1noth1olane. The former reacts specifically...
Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors
Dace, Alexandra, Zhao, Li, Park, Kyung Soo, Furuno, T., Takamura, N., Nakanishi, M., ...
The thyroid hormone 3,3′,5-triiodo-l-thyronine (T3) is essential for growth, differentiation, and development. Its biological activities are mediated by T3 nuclear receptors (TRs). At present, how...
Kaneshige, Masahiro, Kaneshige, Kumiko, Zhu, Xu-guang, Dace, Alexandra, Garrett, Lisa, Carter, Todd A., ...
Patients with mutations in the thyroid hormone receptor β (TRβ) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities. To understand...
Itoh, Yoshiaki, Esaki, Takanori, Kaneshige, Masahiro, Suzuki, Hideyo, Cook, Michelle, Sokoloff, Louis, ...
Brain glucose utilization is markedly depressed in adult rats made cretinous after birth. To ascertain which subtype of thyroid hormone (TH) receptors, TRα1 or TRβ, is involved in the regulation of...
Kaneshige, Masahiro, Suzuki, Hideyo, Kaneshige, Kumiko, Cheng, Jun, Wimbrow, Heather, Barlow, Carrolee, ...
Mutations in the thyroid hormone receptor β (TRβ) gene result in resistance to thyroid hormone. However, it is unknown whether mutations in the TRα gene could lead to a similar disease. To address...
Zhu, Xu-guang, Park, Kyung Soo, Kaneshige, Masahiro, Bhat, Manoj K., Zhu, Qihong, Mariash, Cary N., ...
Thyroid hormone (T3) nuclear receptors (TR) are ligand-dependent transcription factors which regulate growth, differentiation, and development. One emerging hypothesis suggests that TR mediate these...
Miller, Lance D., Park, Kyung Soo, Guo, Qingbin M., Alkharouf, Nawal W., Malek, Renae L., Lee, Norman H., ...
To investigate the transcriptional program underlying thyroid hormone (T3)-induced cell proliferation, cDNA microarrays were used to survey the temporal expression profiles of 4,400 genes. Of 358...
McDonald, Michael P., Wong, Rosemary, Goldstein, Gregory, Weintraub, Bruce, Cheng, Sheue-yann, Crawley, Jacqueline N.
Resistance to thyroid hormone (RTH) is a human syndrome mapped to the thyroid receptor β (TRβ) gene on chromosome 3, representing a mutation of the ligandbinding domain of the TRβ gene. The...
Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance
Miller, Lance D, McPhie, Peter, Suzuki, Hideyo, Kato, Yasuhito, Liu, Edison T, Cheng, Sheue-yann
Gene-expression analysis in cerebellum, heart and white adipose tissue from a knock-in mouse that harbors a human mutation and faithfully reproduces human resistance to thyroid hormone, uncovered...
Furumoto, Hiroko, Ying, Hao, Chandramouli, G. V. R., Zhao, Li, Walker, Robert L., Meltzer, Paul S., ...
Thyroid-stimulating hormone (TSH)-secreting tumors (TSH-omas) are pituitary tumors that constitutively secrete TSH. The molecular genetics underlying this abnormality are not known. We discovered...
Ying, Hao, Furuya, Fumihiko, Willingham, Mark C., Xu, Jianming, O'Malley, Bert W., Cheng, Sheue-yann
Mutations of the thyroid hormone receptor β (TRβ) gene cause resistance to thyroid hormone (RTH). RTH is characterized by increased serum thyroid hormone associated with nonsuppressible...
Araki, Osamu, Ying, Hao, Furuya, Fumihiko, Zhu, Xuguang, Cheng, Sheue-yann
Thyroid hormone (T3) and peroxisome proliferators have overlapping metabolic effects in the maintenance of lipid homeostasis. Their actions are mediated by their respective receptors: thyroid hormone...
O'Shea, Patrick J., Bassett, J.H. Duncan, Cheng, Sheue-yann, Williams, Graham R.
Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation...
Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone β receptor
Furuya, Fumihiko, Hanover, John A., Cheng, Sheue-yann
Activation of the phosphatidylinositol 3-kinase (PI3K)–AKT/protein kinase B signaling pathway has been associated with multiple human cancers. Recently we showed that AKT is activated in both the...
Ying, Hao, Furuya, Fumihiko, Zhao, Li, Araki, Osamu, West, Brian L., Hanover, John A., ...
Overexpression of pituitary tumor–transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid carcinoma...
Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors
Dace, Alexandra, Zhao, Li, Park, Kyung Soo, Furuno, T., Takamura, N., Nakanishi, M., ...
The thyroid hormone 3,3′,5-triiodo-l-thyronine (T3) is essential for growth, differentiation, and development. Its biological activities are mediated by T3 nuclear receptors (TRs). At present, how...
Kaneshige, Masahiro, Kaneshige, Kumiko, Zhu, Xu-guang, Dace, Alexandra, Garrett, Lisa, Carter, Todd A., ...
Patients with mutations in the thyroid hormone receptor β (TRβ) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities. To understand...
Itoh, Yoshiaki, Esaki, Takanori, Kaneshige, Masahiro, Suzuki, Hideyo, Cook, Michelle, Sokoloff, Louis, ...
Brain glucose utilization is markedly depressed in adult rats made cretinous after birth. To ascertain which subtype of thyroid hormone (TH) receptors, TRα1 or TRβ, is involved in the regulation of...
Kaneshige, Masahiro, Suzuki, Hideyo, Kaneshige, Kumiko, Cheng, Jun, Wimbrow, Heather, Barlow, Carrolee, ...
Mutations in the thyroid hormone receptor β (TRβ) gene result in resistance to thyroid hormone. However, it is unknown whether mutations in the TRα gene could lead to a similar disease. To address...
Zhu, Xu-guang, Park, Kyung Soo, Kaneshige, Masahiro, Bhat, Manoj K., Zhu, Qihong, Mariash, Cary N., ...
Thyroid hormone (T3) nuclear receptors (TR) are ligand-dependent transcription factors which regulate growth, differentiation, and development. One emerging hypothesis suggests that TR mediate these...
Miller, Lance D., Park, Kyung Soo, Guo, Qingbin M., Alkharouf, Nawal W., Malek, Renae L., Lee, Norman H., ...
To investigate the transcriptional program underlying thyroid hormone (T3)-induced cell proliferation, cDNA microarrays were used to survey the temporal expression profiles of 4,400 genes. Of 358...
McDonald, Michael P., Wong, Rosemary, Goldstein, Gregory, Weintraub, Bruce, Cheng, Sheue-yann, Crawley, Jacqueline N.
Resistance to thyroid hormone (RTH) is a human syndrome mapped to the thyroid receptor β (TRβ) gene on chromosome 3, representing a mutation of the ligandbinding domain of the TRβ gene. The...
Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance
Miller, Lance D, McPhie, Peter, Suzuki, Hideyo, Kato, Yasuhito, Liu, Edison T, Cheng, Sheue-yann
Gene-expression analysis in cerebellum, heart and white adipose tissue from a knock-in mouse that harbors a human mutation and faithfully reproduces human resistance to thyroid hormone, uncovered...
Furumoto, Hiroko, Ying, Hao, Chandramouli, G. V. R., Zhao, Li, Walker, Robert L., Meltzer, Paul S., ...
Thyroid-stimulating hormone (TSH)-secreting tumors (TSH-omas) are pituitary tumors that constitutively secrete TSH. The molecular genetics underlying this abnormality are not known. We discovered...
Ying, Hao, Furuya, Fumihiko, Willingham, Mark C., Xu, Jianming, O'Malley, Bert W., Cheng, Sheue-yann
Mutations of the thyroid hormone receptor β (TRβ) gene cause resistance to thyroid hormone (RTH). RTH is characterized by increased serum thyroid hormone associated with nonsuppressible...
Araki, Osamu, Ying, Hao, Furuya, Fumihiko, Zhu, Xuguang, Cheng, Sheue-yann
Thyroid hormone (T3) and peroxisome proliferators have overlapping metabolic effects in the maintenance of lipid homeostasis. Their actions are mediated by their respective receptors: thyroid hormone...
Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone β receptor
Furuya, Fumihiko, Hanover, John A., Cheng, Sheue-yann
Activation of the phosphatidylinositol 3-kinase (PI3K)–AKT/protein kinase B signaling pathway has been associated with multiple human cancers. Recently we showed that AKT is activated in both the...
O'Shea, Patrick J., Bassett, J.H. Duncan, Cheng, Sheue-yann, Williams, Graham R.
Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation...
Ying, Hao, Furuya, Fumihiko, Zhao, Li, Araki, Osamu, West, Brian L., Hanover, John A., ...
Overexpression of pituitary tumor–transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid carcinoma...
Rapid nongenomic actions of thyroid hormone
Hiroi, Yukio, Kim, Hyung-Hwan, Ying, Hao, Furuya, Fumihiko, Huang, Zhihong, Simoncini, Tommaso, ...
The binding of thyroid hormone to the thyroid hormone receptor (TR) mediates important physiological effects. However, the transcriptional effects of TR mediated by the thyroid response element (TRE)...
Impaired Adipogenesis Caused by a Mutated Thyroid Hormone α1 Receptor▿
Ying, Hao, Araki, Osamu, Furuya, Fumihiko, Kato, Yasuhito, Cheng, Sheue-Yann
Thyroid hormone (T3) is critical for growth, differentiation, and maintenance of metabolic homeostasis. Mice with a knock-in mutation in the thyroid hormone receptor α gene (TRα1PV) were created...
Nuclear Receptor Corepressor Is a Novel Regulator of Phosphatidylinositol 3-Kinase Signaling▿
Furuya, Fumihiko, Guigon, Celine J., Zhao, Li, Lu, Changxue, Hanover, John A., Cheng, Sheue-yann
The nuclear receptor corepressor (NCoR) regulates the activities of DNA-binding transcription factors. Recent observations of its distribution in the extranuclear compartment raised the possibility...
Glogowska, Aleksandra, Pyka, Janette, Kehlen, Astrid, Los, Marek, Perumal, Paul, Weber, Ekkehard, ...
The intracellular domains of the membrane-anchoring regions of some precursors of epidermal growth factor (EGF) family members have intrinsic biologic activities. We have determined the role of the...
Regulation of β-Catenin by a Novel Nongenomic Action of Thyroid Hormone β Receptor▿
Guigon, Celine J., Zhao, Li, Lu, Changxue, Willingham, Mark C., Cheng, Sheue-yann
We previously created a knock-in mutant mouse harboring a dominantly negative mutant thyroid hormone receptor β (TRβPV/PV mouse) that spontaneously develops a follicular thyroid carcinoma similar...
SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis
Nofsinger, Russell R., Li, Pingping, Hong, Suk-Hyun, Jonker, Johan W., Barish, Grant D., Ying, Hao, ...
The nuclear receptor corepressor, silencing mediator of retinoid and thyroid hormone receptors (SMRT), is recruited by a plethora of transcription factors to mediate lineage and signal-dependent...
Lu, Changxue, Willingham, Mark C., Furuya, Fumihiko, Cheng, Sheue-yann
TSH-secreting pituitary tumors (TSHomas) are pituitary tumors that constitutively secrete TSH. Molecular mechanisms underlying this abnormality are largely undefined. We recently created a knock-in...