Shiming Chen

FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo (2008)

Mali, Raghuveer S, Peng, Guang-Hua, Zhang, Xiao, Dang, Loan, Chen, Shiming, Mitton, Kenneth P

Abstract Background FIZ1 (Flt-3 Interacting Zinc-finger) is a broadly expressed protein of unknown function. We reported previously that in the mammalian retina, FIZ1 interacts with NRL...

Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation (2007)

Peng, Guang-Hua, Chen, Shiming

The homeodomain transcription factor Crx is required for expression of many photoreceptor genes in the mammalian retina. The mechanism by which Crx activates transcription remains to be determined....

The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes (2005)

Peng, Guang-Hua, Ahmad, Omar, Ahmad, Faisel, Liu, Jianfeng, Chen, Shiming

Nr2e3 is an orphan nuclear receptor expressed specifically by retinal photoreceptor cells. Mutations in Nr2e3 result in syndromes characterized by excess blue cones and loss of rods: enhanced S-cone...

The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes (2005)

Peng, Guang-Hua, Ahmad, Omar, Ahmad, Faisel, Liu, Jianfeng, Chen, Shiming

Nr2e3 is an orphan nuclear receptor expressed specifically by retinal photoreceptor cells. Mutations in Nr2e3 result in syndromes featuring excess blue cones and loss of rods: enhanced S-cone...

QRX, a Novel Homeobox Gene, Modulates Photoreceptor Gene Expression (2004)

Wang, Qing-liang, Chen, Shiming, Esumi, Noriko, Swain, Prabodh K., Haines, Heidi S., Peng, Guanghua, ...

A novel paired-like homeobox gene, designated as Qrx, was identified by a yeast one-hybrid screen using the bovine Rhodopsin promoter Ret-1 DNA regulatory element as bait. Qrx is preferentially...

QRX, a novel homeobox gene, modulates photoreceptor gene expression (2004)

Wang, Qing-liang, Chen, Shiming, Esumi, Noriko, Swain, Prabodh K., Haines, Heidi S., Peng, Guanghua, ...

A novel paired-like homeobox gene, designated as Qrx, was identified by a yeast one-hybrid screen using the bovine Rhodopsin promoter Ret-1 DNA regulatory element as bait. Qrx is preferentially...

Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization (2004)

Chen, Shiming, Peng, Guang-Hua, Wang, Xuejiao, Smith, Annette C., Grote, Sara K., Sopher, Bryce L., ...

Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disorder caused by expansion of a polyglutamine tract in the ataxin-7 protein. A unique feature of SCA7 is degeneration of...

QRX, a Novel Homeobox Gene, Modulates Photoreceptor Gene Expression (2004)

Wang, Qing-liang, Chen, Shiming, Esumi, Noriko, Swain, Prabodh K., Haines, Heidi S., Peng, Guanghua, ...

A novel paired-like homeobox gene, designated as Qrx, was identified by a yeast one-hybrid screen using the bovine Rhodopsin promoter Ret-1 DNA regulatory element as bait. Qrx is preferentially...

Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization (2003)

Chen, Shiming, Peng, Guang-Hua, Wang, Xuejiao, Smith, Annette C., Grote, Sara K., Sopher, Bryce L., ...

Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disorder caused by expansion of a polyglutamine tract in the ataxin-7 protein. A unique feature of SCA7 is degeneration of...

Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization (2003)

Chen, Shiming, Peng, Guang-Hua, Wang, Xuejiao, Smith, Annette C., Grote, Sara K., Sopher, Bryce L., ...

Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disorder caused by expansion of a polyglutamine tract in the ataxin-7 protein. A unique feature of SCA7 is degeneration of...

Functional analysis of cone-rod homeobox (CRX) mutations associated with retinal dystrophy (2002)

Chen, Shiming, Wang, Qing-Liang, Xu, Siqun, Liu, Ivy, Li, Lili Y., Wang, Yufang, ...

Mutations in the photoreceptor transcription factor cone–rod homeobox (CRX) have been identified in patients with several forms of retinal degenerative disease. To investigate the mechanisms by...

Functional Dissection of the Promoter of the Interphotoreceptor Retinoid-Binding Protein Gene: The Cone-Rod-Homeobox Element Is Essential for Photoreceptor-Specific Expression In Vivo (1999)

Fei, Yijian, Matragoon, Suraporn, Smith, Sylvia B., Overbeek, Paul A., Chen, Shiming, Zack, Donald J., ...

The essential control elements in the interphotoreceptor retinoid-binding protein gene (IRBP) promoter are located between −156 and +19. The −156/−109 sequence contains a...

Instability of composite beams in hogging bending. (1992)

Chen, Shiming.

Thesis (Ph. D.)--University of Warwick, 1992.

A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX

Li, Xiaodong, Chen, Shiming, Wang, Qingliang, Zack, Donald J., Snyder, Solomon H., Borjigin, Jimo

The circadian hormone melatonin is synthesized predominantly in the pineal gland by the actions of two pineal-specific enzymes: serotonin N-acetyltransferase (NAT) and...

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

Palhan, Vikas B., Chen, Shiming, Peng, Guang-Hua, Tjernberg, Agneta, Gamper, Armin M., Fan, Yuxin, ...

Spinocerebellar ataxia type 7 (SCA7) is characterized by cone-rod dystrophy retinal degeneration and is caused by a polyglutamine [poly(Q)] expansion within ataxin-7, a protein of previously unknown...

A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX

Li, Xiaodong, Chen, Shiming, Wang, Qingliang, Zack, Donald J., Snyder, Solomon H., Borjigin, Jimo

The circadian hormone melatonin is synthesized predominantly in the pineal gland by the actions of two pineal-specific enzymes: serotonin N-acetyltransferase (NAT) and...

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

Palhan, Vikas B., Chen, Shiming, Peng, Guang-Hua, Tjernberg, Agneta, Gamper, Armin M., Fan, Yuxin, ...

Spinocerebellar ataxia type 7 (SCA7) is characterized by cone-rod dystrophy retinal degeneration and is caused by a polyglutamine [poly(Q)] expansion within ataxin-7, a protein of previously unknown...