Shinji Takai, Rie Matsushima-Nishiwaki, Seiji Adachi, Hideo Natsume, Chiho Minamitani, Jun Mizutani, ...
We previously showed that the mitogen-activated protein (MAP) kinase superfamily, p44/p42 MAP kinase, p38 MAP kinase, and stress-activated protein kinase (SAPK)/c-Jun N-terminal (JNK), positively...
Takaesu, Azusa, Watanabe, Kiyotaka, Takai, Shinji, Sasaki, Yukako, Orino, Koichi
Abstract Background Iron-storage protein, ferritin plays a central role in iron metabolism. Ferritin has dual function to store iron and segregate iron for protection of iron-catalyzed reactive...
Shinji Takai, Rie Matsushima-Nishiwaki, Seiji Adachi, Hideo Natsume, Chiho Minamitani, Jun Mizutani, ...
We previously showed that the mitogen-activated protein (MAP) kinase superfamily, p44/p42 MAP kinase, p38 MAP kinase, and stress-activated protein kinase (SAPK)/c-Jun N-terminal (JNK), positively...
Development of Chymase Inhibitor as a Potent Agent for Preventing Vascular Diseases (2005)
Shinji Takai, Denan Jin, Michiko Muramatsu, Mizuo Miyazaki
Chymase activates not only angiotensin I to angiotensin II but also pro-matrix metalloproteinase-9 to matrix metalloproteinase-9. A clinical trial of an angiotensin II receptor blocker for preventing...
Development of Chymase Inhibitor as a Potent Agent for Preventing Vascular Diseases (2005)
Shinji Takai, Denan Jin, Michiko Muramatsu, Mizuo Miyazaki
Chymase activates not only angiotensin I to angiotensin II but also pro-matrix metalloproteinase-9 to matrix metalloproteinase-9. A clinical trial of an angiotensin II receptor blocker for preventing...
Impact of chymase inhibitor on cardiac function and survival after myocardial infarction (2003)
Jin, Denan, Takai, Shinji, Yamada, Mayumi, Sakaguchi, Masato, Kamoshita, Keiichi, Ishida, Koichi, ...
Objectives: Recent studies have demonstrated that hamsters, like humans, possess both angiotensin converting enzyme (ACE)- and chymase-dependent angiotensin (Ang) II-forming pathways in...
ISOLATION OF NON-PILIATED CLONE OF CORYNEBACTERIUM RENALE STRAIN 115 (1981)
OKAMOTO, Ryoichi, TAKAI, Shinji, YANAGAWA, Ryo, SATO, Hisaaki
A non-piliated (P^-) clone was isolated from 368 colonies of a densely piliated (P^+) clone of Corynebacterium renale strain 115 by means of a very weak agglutination with anti-pili serum. Lack of...
OKAMOTO, Ryoichi, YANAGAWA, Ryo, MAEJIMA, Kazuyoshi, TAKAI, Shinji
Immunization of mice with killed organisms of Corynebacterium renale did not prevent the ascending of organisms of C. renale from the urinary bladder into the kidneys, despite the fact that the...
ISOLATION OF NON-PILIATED CLONE OF CORYNEBACTERIUM RENALE STRAIN 115 (1981)
OKAMOTO, Ryoichi, TAKAI, Shinji, YANAGAWA, Ryo, SATO, Hisaaki
ISOLATION OF NON-PILIATED CLONE OF CORYNEBACTERIUM RENALE STRAIN 115 (1981)
OKAMOTO, Ryoichi, TAKAI, Shinji, YANAGAWA, Ryo, SATO, Hisaaki
Restriction Fragment Length Polymorphisms of Virulence Plasmids in Rhodococcus equi
Takai, Shinji, Shoda, Masato, Sasaki, Yukako, Tsubaki, Shiro, Fortier, Guillaume, Pronost, Stephane, ...
Virulent Rhodococcus equi, which is a well-known cause of pyogranulomatous pneumonia in foals, possesses a large plasmid encoding virulence-associated 15- to 17-kDa antigens. Foal and soil isolates...
Epidemiology of Rhodococcus equi Strains on Thoroughbred Horse Farms
Morton, Anna C., Begg, Angela P., Anderson, Garry A., Takai, Shinji, Lämmler, Christoph, Browning, Glenn F.
Pulsed-field gel electrophoresis of restriction endonuclease-digested genomic DNA from a large collection of clinical isolates of Rhodococcus equi, an important pathogen of foals, was used to compare...
DNA Sequence and Comparison of Virulence Plasmids from Rhodococcus equi ATCC 33701 and 103
Takai, Shinji, Hines, Stephen A., Sekizaki, Tsutomu, Nicholson, Vivian M., Alperin, Debra A., Osaki, Makoto, ...
The virulence plasmids of the equine virulent strains Rhodococcus equi ATCC 33701 and 103 were sequenced, and their genetic structure was analyzed. p33701 was 80,610 bp in length, and p103 was 1 bp...
Virulence Plasmid of Rhodococcus equi Contains Inducible Gene Family Encoding Secreted Proteins
Byrne, Barbara A., Prescott, John F., Palmer, Guy H., Takai, Shinji, Nicholson, Vivian M., Alperin, Debra C., ...
Rhodococcus equi causes severe pyogranulomatous pneumonia in foals. This facultative intracellular pathogen produces similar lesions in immunocompromised humans, particularly in AIDS patients....
Performance of Five Serological Assays for Diagnosis of Rhodococcus equi Pneumonia in Foals
Giguère, Steeve, Hernandez, Jorge, Gaskin, Jack, Prescott, John F., Takai, Shinji, Miller, Corey
The performance of four enzyme-linked immunosorbent assays (ELISAs) (ELISA-6939, ELISA-33701, ELISA-VapA, and ELISA-California) and an agar gel immunodiffusion test for diagnosis of Rhodococcus equi...
Virulence of Rhodococcus equi Isolated from Cats and Dogs
Takai, Shinji, Martens, Ronald J., Julian, Alan, Garcia Ribeiro, Márcio, Rodrigues De Farias, Marconi, Sasaki, Yukako, ...
Nine cat isolates and nine dog isolates of Rhodococcus equi from clinical material were investigated for the presence of the virulence-associated antigens (VapA and VapB) and virulence plasmids. Five...
Lührmann, Anja, Mauder, Norman, Sydor, Tobias, Fernandez-Mora, Eugenia, Schulze-Luehrmann, Jan, Takai, Shinji, ...
Rhodococcus equi is a gram-positive intracellular pathogen that can cause severe bronchopneumonia in foals and AIDS patients. It has been reported that advanced infection of foals is characterized by...
Tsutsumi, Yoshiaki, Matsubara, Hiroaki, Masaki, Hiroya, Kurihara, Hiroki, Murasawa, Satoshi, Takai, Shinji, ...
Angiotensin II (Ang II) is a potent vasopressor peptide that interacts with 2 major receptor isoforms — AT1 and AT2. Although blood pressure is increased in AT2 knockout mice, the underlying...
Makrai, László, Takayama, Saki, Dénes, Béla, Hajtós, István, Sasaki, Yukako, Kakuda, Tsutomu, ...
The plasmid types and serotypes of 164 Rhodococcus equi strains obtained from submaxillary lymph nodes of swine from different piggeries in 28 villages and towns located throughout the country were...
Blockade of Neutrophil Elastase Attenuates Severe Liver Injury in Hepatitis B Transgenic Mice
Takai, Shinji, Kimura, Kiminori, Nagaki, Masahito, Satake, Shinichi, Kakimi, Kazuhiro, Moriwaki, Hisataka
Serine proteinases produced by polymorphonuclear neutrophils play important roles in neutrophil-mediated tissue injury at inflammatory sites. Although neutrophil recruitment to the liver has been...
Restriction Fragment Length Polymorphisms of Virulence Plasmids in Rhodococcus equi
Takai, Shinji, Shoda, Masato, Sasaki, Yukako, Tsubaki, Shiro, Fortier, Guillaume, Pronost, Stephane, ...
Virulent Rhodococcus equi, which is a well-known cause of pyogranulomatous pneumonia in foals, possesses a large plasmid encoding virulence-associated 15- to 17-kDa antigens. Foal and soil isolates...
Epidemiology of Rhodococcus equi Strains on Thoroughbred Horse Farms
Morton, Anna C., Begg, Angela P., Anderson, Garry A., Takai, Shinji, Lämmler, Christoph, Browning, Glenn F.
Pulsed-field gel electrophoresis of restriction endonuclease-digested genomic DNA from a large collection of clinical isolates of Rhodococcus equi, an important pathogen of foals, was used to compare...
DNA Sequence and Comparison of Virulence Plasmids from Rhodococcus equi ATCC 33701 and 103
Takai, Shinji, Hines, Stephen A., Sekizaki, Tsutomu, Nicholson, Vivian M., Alperin, Debra A., Osaki, Makoto, ...
The virulence plasmids of the equine virulent strains Rhodococcus equi ATCC 33701 and 103 were sequenced, and their genetic structure was analyzed. p33701 was 80,610 bp in length, and p103 was 1 bp...
Virulence Plasmid of Rhodococcus equi Contains Inducible Gene Family Encoding Secreted Proteins
Byrne, Barbara A., Prescott, John F., Palmer, Guy H., Takai, Shinji, Nicholson, Vivian M., Alperin, Debra C., ...
Rhodococcus equi causes severe pyogranulomatous pneumonia in foals. This facultative intracellular pathogen produces similar lesions in immunocompromised humans, particularly in AIDS patients....
Performance of Five Serological Assays for Diagnosis of Rhodococcus equi Pneumonia in Foals
Giguère, Steeve, Hernandez, Jorge, Gaskin, Jack, Prescott, John F., Takai, Shinji, Miller, Corey
The performance of four enzyme-linked immunosorbent assays (ELISAs) (ELISA-6939, ELISA-33701, ELISA-VapA, and ELISA-California) and an agar gel immunodiffusion test for diagnosis of Rhodococcus equi...
Virulence of Rhodococcus equi Isolated from Cats and Dogs
Takai, Shinji, Martens, Ronald J., Julian, Alan, Garcia Ribeiro, Márcio, Rodrigues De Farias, Marconi, Sasaki, Yukako, ...
Nine cat isolates and nine dog isolates of Rhodococcus equi from clinical material were investigated for the presence of the virulence-associated antigens (VapA and VapB) and virulence plasmids. Five...
Lührmann, Anja, Mauder, Norman, Sydor, Tobias, Fernandez-Mora, Eugenia, Schulze-Luehrmann, Jan, Takai, Shinji, ...
Rhodococcus equi is a gram-positive intracellular pathogen that can cause severe bronchopneumonia in foals and AIDS patients. It has been reported that advanced infection of foals is characterized by...
Tsutsumi, Yoshiaki, Matsubara, Hiroaki, Masaki, Hiroya, Kurihara, Hiroki, Murasawa, Satoshi, Takai, Shinji, ...
Angiotensin II (Ang II) is a potent vasopressor peptide that interacts with 2 major receptor isoforms — AT1 and AT2. Although blood pressure is increased in AT2 knockout mice, the underlying...
Makrai, László, Takayama, Saki, Dénes, Béla, Hajtós, István, Sasaki, Yukako, Kakuda, Tsutomu, ...
The plasmid types and serotypes of 164 Rhodococcus equi strains obtained from submaxillary lymph nodes of swine from different piggeries in 28 villages and towns located throughout the country were...
Blockade of Neutrophil Elastase Attenuates Severe Liver Injury in Hepatitis B Transgenic Mice
Takai, Shinji, Kimura, Kiminori, Nagaki, Masahito, Satake, Shinichi, Kakimi, Kazuhiro, Moriwaki, Hisataka
Serine proteinases produced by polymorphonuclear neutrophils play important roles in neutrophil-mediated tissue injury at inflammatory sites. Although neutrophil recruitment to the liver has been...
Miyazaki, Mizuo, Sakonjo, Hiroshi, Takai, Shinji
We investigated the relationship between angiotensin II formation and the development of atherosclerotic lesions in the aorta of monkeys (Macaca fascicularis) fed a high-cholesterol (4% cholesterol...
Muramatsu, Michiko, Yamada, Mayumi, Takai, Shinji, Miyazaki, Mizuo
We investigated the profound involvement of mast cell chymase, an alternative angiotensin II-generating enzyme, in angiogenesis using a specific chymase inhibitor. We also studied the functional...
Shimizu, Yuji, Matsumoto, Kenji, Okayama, Yoshimichi, Kentaro, Sakai, Maeno, Toshitaka, Suga, Tatsuo, ...
Although IL-3 is commonly used for culture of human progenitor-derived mast cells together with Stem cell factor (SCF) and IL-6, the effect of IL-3 on human mast cell differentiation has not been...
Streptococcus suis in Humans, Thailand
Takamatsu, Daisuke, Wongsawan, Korawan, Osaki, Makoto, Nishino, Hiroto, Ishiji, Tomono, Tharavichitkul, Prasit, ...
Streptococcus suis in Humans, Thailand
Takai, Shinji, Matsushima-Nishiwaki, Rie, Adachi, Seiji, Natsume, Hideo, Minamitani, Chiho, Mizutani, Jun, ...
We previously showed that the mitogen-activated protein (MAP) kinase superfamily, p44/p42 MAP kinase, p38 MAP kinase, and stress-activated protein kinase (SAPK)/c-Jun N-terminal (JNK), positively...