Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice (2009)
Hoshi, Sayuri, Hoshi, Nobuo, Okamoto, Minoru, Paiz, Jorge, Kusakabe, Takashi, Ward, Jerrold M., ...
NKX2-1 is a homeodomain transcription factor that is critical for genesis of the thyroid and transcription of the thyroid-specific genes. Nkx2-1-thyroid-conditional hypomorphic mice were previously...
Tomita, Takeshi, Kimura, Shioko
Abstract Background Secretoglobin (SCGB) 3A1 is a secretory protein of small molecular weight with tumor suppressor function. It is highly expressed in lung and trachea in both human and mouse, with...
Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2 (2003)
Kimura, Shioko, Kawabe, Mayumi, Yu, Aiming, Morishima, Hideki, Fernandez-Salguero, Pedro, Hammons, George J., ...
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant of the heterocyclic amines found in cooked meat. Based on in vitro studies with rats and humans, CYP1A2 is...
Kimura, Shioko, Kawabe, Mayumi, Ward, Jerrold M., Morishima, Hideki, Kadlubar, Fred F., Hammons, George J., ...
4-Aminobiphenyl (4-ABP), a potent carcinogen in rodents (liver cancer) and human (bladder cancer), is found as an environmental contaminant and in tobacco smoke. Hemoglobin adducts and lung DNA...
Yamaguchi, Noriko, Kimura, Shioko, McBride, O. Wesley, Hori, Hisae, Yamada, Yoshihiko, Kanamori, Tetsuko, ...
In an effort to identify new members of the collagen family, we screened a human placenta cDNA library with a collagenous probe. A novel 3.7 kb cDNA was identified encoding an open reading frame of...
cDNA and amino acid sequences of two members of the human P450IIC gene subfamily (1987)
Kimura, Shioko, Pastewka, Jullia, Gelboin, Harry V., Gonzalez, Frank J.
cDNA and complete amino acid sequence of mouse P2450: allelic variant of mouse P3450 gene (1986)
Kimura, Shioko, Nebert, Daniel W.
From a λgt11 cDNA library derived from isosafrole-treated DBA/2N mouse liver (1), the longest cDNA insert was sequenced by the dideoxy method. Over a range of 1,847 bp, the nucleotide sequence of...
Mouse cytochrome P3-450: complete cDNA and amino acid sequence (1984)
Kimura, Shioko, Gonzalez, Frank J., Nebert, Daniel W.
A full-length cDNA clone. (1,894 nucleotides) of mouse cytochrome P3-450 was isolated with the Okayama-Berg vector and sequenced. An open reading frame spanned positions 61 to 1602. The first 25, and...
Autoregulation of thyroid-specific gene transcription by thyroglobulin
Suzuki, Koichi, Lavaroni, Stefano, Mori, Atsumi, Ohta, Masanori, Saito, Jun, Pietrarelli, Michele, ...
Thyroglobulin (TG), the primary synthetic product of the thyroid, is the macromolecular precursor of thyroid hormones. TG synthesis, iodination, storage in follicles, and degradation control thyroid...
Niimi, Tomoaki, Nagashima, Kunio, Ward, Jerrold M., Minoo, Parviz, Zimonjic, Drazen B., Popescu, Nicholas C., ...
T/EBP/NKX2.1, a member of the NKX family of homeodomain-containing transcription factors, regulates the expression of a number of genes in lung and thyroid. Here we describe the isolation and...
Suzuki, Koichi, Lavaroni, Stefano, Mori, Atsumi, Okajima, Fumikazu, Kimura, Shioko, Katoh, Ryohei, ...
Thyroid transcription factor 1 (TTF-1) was identified for its critical role in thyroid-specific gene expression; its level in the thyroid is regulated by thyrotropin-increased cyclic AMP levels....
Pohlenz, Joachim, Dumitrescu, Alexandra, Zundel, Dorothee, Martiné, Ursula, Schönberger, Winfried, Koo, Eugene, ...
Three genes, TTF1, TTF2, and PAX8, involved in thyroid gland development and migration have been identified. Yet systematic screening for defects in these genes in thyroid dysgenesis gave essentially...
Chiba, Yoshihiko, Srisodsai, Achara, Supavilai, Porntip, Kimura, Shioko
Airway inflammation is thought to play a major role in the pathogenesis of bronchial asthma. The precise role of individual inflammatory cells, mediator and asthma related genes in allergic lung...
Induction of uteroglobin-related protein 2 (Ugrp2) expression by EGF and TGFα
Yamada, Atsushi, Kimura, Shioko
Uteroglobin-related protein 2 (UGRP2) is thought to play a role in inflammation and/or epithelial cell differentiation in the lung. Induction of Ugrp2 mRNA expression by epidermal growth factor (EGF)...
Yamada, Atsushi, Sheikh, Faruk, Niimi, Tomoaki, DeMayo, Francesco J., Keegan, Achsah D., Donnelly, Raymond P., ...
Uteroglobin-related proteins 1 and 2 (UGRP1 and -2) are thought to play important roles in inflammation and immunologic responses in the lung. In this study we demonstrate that IL-4 and IL-13 enhance...
Autoregulation of thyroid-specific gene transcription by thyroglobulin
Suzuki, Koichi, Lavaroni, Stefano, Mori, Atsumi, Ohta, Masanori, Saito, Jun, Pietrarelli, Michele, ...
Thyroglobulin (TG), the primary synthetic product of the thyroid, is the macromolecular precursor of thyroid hormones. TG synthesis, iodination, storage in follicles, and degradation control thyroid...
Niimi, Tomoaki, Nagashima, Kunio, Ward, Jerrold M., Minoo, Parviz, Zimonjic, Drazen B., Popescu, Nicholas C., ...
T/EBP/NKX2.1, a member of the NKX family of homeodomain-containing transcription factors, regulates the expression of a number of genes in lung and thyroid. Here we describe the isolation and...
Suzuki, Koichi, Lavaroni, Stefano, Mori, Atsumi, Okajima, Fumikazu, Kimura, Shioko, Katoh, Ryohei, ...
Thyroid transcription factor 1 (TTF-1) was identified for its critical role in thyroid-specific gene expression; its level in the thyroid is regulated by thyrotropin-increased cyclic AMP levels....
Pohlenz, Joachim, Dumitrescu, Alexandra, Zundel, Dorothee, Martiné, Ursula, Schönberger, Winfried, Koo, Eugene, ...
Three genes, TTF1, TTF2, and PAX8, involved in thyroid gland development and migration have been identified. Yet systematic screening for defects in these genes in thyroid dysgenesis gave essentially...
Niimi, Tomoaki, Munakata, Mitsuru, Keck-Waggoner, Catherine L., Popescu, Nicholas C., Levitt, Roy C., Hisada, Michie, ...
Several traits associated with asthma phenotypes, such as high total serum immunoglobulin E and bronchial hyperresponsiveness, have been linked by numerous genome-screen studies and linkage analyses...
Ward, Jerrold M., Yoon, Michung, Anver, Miriam R., Haines, Diana C., Kudo, Gen, Gonzalez, Frank J., ...
The C57BL/6, 129, and B6,129 mouse strains or stocks have been commonly used to generate targeted mutant mice. The pathology of these mice is not well characterized. In studies of these aging mice,...
Disruption of Lymphocyte Function and Signaling in CD45–associated Protein–null Mice
Matsuda, Akio, Motoya, Satoshi, Kimura, Shioko, McInnis, Renee, Maizel, Abby L., Takeda, Akiko
CD45-AP specifically associates with CD45, a protein tyrosine phosphatase essential for lymphocyte differentiation and antigen receptor–mediated signal transduction. CD45 is thought to mediate...
Uteroglobin-related Protein 1 Expression Suppresses Allergic Airway Inflammation in Mice
Chiba, Yoshihiko, Kurotani, Reiko, Kusakabe, Takashi, Miura, Tomiko, Link, Benjamin W., Misawa, Miwa, ...
Rationale: Uteroglobin-related protein (UGRP) 1, which is highly expressed in the epithelial cells of the airways, has been suggested to play a role in lung inflammation.
Role of Secretoglobin 3A2 in Lung Development
Kurotani, Reiko, Tomita, Takeshi, Yang, Qian, Carlson, Bradley A., Chen, Chi, Kimura, Shioko
Rationale: Secretoglobin 3A2 (SCGB3A2) was originally identified as a downstream target in lung for the homeodomain transcription factor NKX2-1, whose null mutation resulted in severely hypoplastic...
Tomita, Takeshi, Kido, Taketomo, Kurotani, Reiko, Iemura, Shun-ichiro, Sterneck, Esta, Natsume, Tohru, ...
Secretoglobin (SCGB) 3A2 is a small molecular weight secreted protein predominantly expressed in lung airways. We previously demonstrated that the expression of SCGB3A2 is regulated by homeodomain...