Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
ABSTRACT: Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas alpha-synuclein has been found to be...
Huang, Shenghai, Liang, Jingjing, Zheng, Mengjie, Li, Xinyi, Wang, Meiling, Wang, Ping, ...
The prion protein (PrP) level in muscle has been reported to be elevated in patients with inclusion-body myositis, polymyositis, dermatomyositis, and neurogenic muscle atrophy, but it is not clear...
LRRK2 in Parkinson's disease and dementia with Lewy bodies (2006)
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
Abstract Background Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD)....
LRRK2 in Parkinson's disease and dementia with Lewy bodies. (2006)
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
BACKGROUND: Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD). To...
Pastore, Manuela, Chin, Steven S., Bell, Karen L., Dong, Zhiqian, Yang, Qiwei, Yang, Lizhu, ...
Creutzfeldt-Jakob disease (CJD), the most common human prion disease, includes sporadic (s) and familial (f) forms. Regardless of etiology, both forms are thought to share the pathogenic mechanism...
Antibody to DNA detects scrapie but not normal prion protein. (2004)
Zou, Wen-Quan, Zheng, Jian, Gray, Donald M., Gambetti, Pierluigi, Chen, Shu G.
Prion diseases, a group of fatal neurodegenerative disorders, are characterized by the presence of the abnormal scrapie isoform of prion protein (PrP(Sc)) in affected brains. A conformational change...
Sporadic and familial CJD: classification and characterisation (2003)
Gambetti, Pierluigi, Kong, Qingzhong, Zou, Wenquan, Parchi, Piero, Chen, Shu G
Prion diseases are unique transmissible neurodegenerative diseases that have diverse phenotypes and can be familial, sporadic, or acquired by infection. Recent findings indicate that the PrP genotype...
Genetic influence on the structural variations of the abnormal prion protein. (2000)
Parchi, Piero, Zou, Wenquan, Wang, Wen, Brown, Paul, Capellari, Sabina, Ghetti, Bernardino, ...
Prion diseases are characterized by the presence of the abnormal prion protein PrP(Sc), which is believed to be generated by the conversion of the alpha-helical structure that predominates in the...
Characterization of Antibody Specific for Disease Associated Prion Protein (1998)
Prion diseases are characterized by the presence of the abnormal scrapie isoform of prion protein (Prp(exp Sc)) in affected brains. A conformational change is believed to convert the normal cellular...
Parchi, Piero, Chen, Shu G., Brown, Paul, Zou, Wenquan, Capellari, Sabina, Budka, Herbert, ...
The clinicopathological phenotype of the Gerstmann-Sträussler-Scheinker disease (GSS) variant linked to the codon 102 mutation in the prion protein (PrP) gene (GSS P102L) shows a high heterogeneity....
Parchi, Piero, Chen, Shu G., Brown, Paul, Zou, Wenquan, Capellari, Sabina, Budka, Herbert, ...
The clinicopathological phenotype of the Gerstmann–Sträussler–Scheinker disease (GSS) variant linked to the codon 102 mutation in the prion protein (PrP) gene (GSS P102L) shows a high...
Genetic influence on the structural variations of the abnormal prion protein
Parchi, Piero, Zou, Wenquan, Wang, Wen, Brown, Paul, Capellari, Sabina, Ghetti, Bernardino, ...
Prion diseases are characterized by the presence of the abnormal prion protein PrPSc, which is believed to be generated by the conversion of the α-helical structure that predominates in the normal...
Antibody to DNA detects scrapie but not normal prion protein
Zou, Wen-Quan, Zheng, Jian, Gray, Donald M., Gambetti, Pierluigi, Chen, Shu G.
Prion diseases, a group of fatal neurodegenerative disorders, are characterized by the presence of the abnormal scrapie isoform of prion protein (PrPSc) in affected brains. A conformational change is...
LRRK2 in Parkinson's disease and dementia with Lewy bodies
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
Parchi, Piero, Chen, Shu G., Brown, Paul, Zou, Wenquan, Capellari, Sabina, Budka, Herbert, ...
The clinicopathological phenotype of the Gerstmann–Sträussler–Scheinker disease (GSS) variant linked to the codon 102 mutation in the prion protein (PrP) gene (GSS P102L) shows a high...
Genetic influence on the structural variations of the abnormal prion protein
Parchi, Piero, Zou, Wenquan, Wang, Wen, Brown, Paul, Capellari, Sabina, Ghetti, Bernardino, ...
Prion diseases are characterized by the presence of the abnormal prion protein PrPSc, which is believed to be generated by the conversion of the α-helical structure that predominates in the normal...
Antibody to DNA detects scrapie but not normal prion protein
Zou, Wen-Quan, Zheng, Jian, Gray, Donald M., Gambetti, Pierluigi, Chen, Shu G.
Prion diseases, a group of fatal neurodegenerative disorders, are characterized by the presence of the abnormal scrapie isoform of prion protein (PrPSc) in affected brains. A conformational change is...
LRRK2 in Parkinson's disease and dementia with Lewy bodies
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
Pastore, Manuela, Chin, Steven S., Bell, Karen L., Dong, Zhiqian, Yang, Qiwei, Yang, Lizhu, ...
Creutzfeldt-Jakob disease (CJD), the most common human prion disease, includes sporadic (s) and familial (f) forms. Regardless of etiology, both forms are thought to share the pathogenic mechanism...
Huang, Shenghai, Liang, Jingjing, Zheng, Mengjie, Li, Xinyi, Wang, Meiling, Wang, Ping, ...
The prion protein (PrP) level in muscle has been reported to be elevated in patients with inclusion-body myositis, polymyositis, dermatomyositis, and neurogenic muscle atrophy, but it is not clear...
Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease
Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas α-synuclein has been found to be the major...