Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model (2008)
Ohtomo, Shuichi, Nangaku, Masaomi, Izuhara, Yuko, Takizawa, Shunya, Miyata, Toshio
Background. Chronic renal hypoxia is suspected to play a pathogenic role in the genesis of diabetic nephropathy (DN). Cobalt enhances the activity of the hypoxia-inducible factor (HIF), a key factor...
Izuhara, Yuko, Nangaku, Masaomi, Takizawa, Shunya, Takahashi, Satoru, Shao, Jing, Oishi, Hisashi, ...
Background. The reno- and cardiovascular-protective effects of angiotensin II receptor blockers (ARBs), have been ascribed, at least in part, to their ability to inhibit the formation of advanced...