Shushant Jain

The Parkinson disease-associated Leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation (2008)

Zambrano, Ibardo, Kaganovich, Alice, Beilina, Alexandra, ...

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and apparently sporadic Parkinson disease. LRRK2 is a multidomain protein kinase with autophosphorylation activity. It...

Analysis of IFT74as a candidate gene for chromosome 9p-linked ALS-FTD (2006)

Momeni, Parastoo, Schymick, Jennifer, Jain, Shushant, Cookson, Mark R, Cairns, Nigel J, Greggio, Elisa, ...

Abstract Background A new locus for amyotrophic lateral sclerosis – frontotemporal dementia (ALS-FTD) has recently been ascribed to chromosome 9p. Methods We identified chromosome 9p segregating...

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data (2005)

Khan, Naheed L., Jain, Shushant, Lynch, John M., Pavese, Nicola, Abou-Sleiman, Patrick, Holton, Janice L., ...

We have established that the frequency of LRRK2 mutations in a series of 118 cases of familial Parkinson's disease is 5.1%. In the largest family with autosomal dominant, late-onset Parkinson's...

Elevated amyloid {beta} protein (A{beta}42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene (2005)

Ertekin-Taner, Nilüfer, Ronald, James, Feuk, Lars, Prince, Jonathan, Tucker, Michael, Younkin, Linda, ...

Plasma amyloid β protein (Aβ42) levels and late onset Alzheimer's disease (LOAD) have been linked to the same region on chromosome 10q. The PLAU gene within this region encodes urokinase-type...

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data (2005)

Khan, Naheed L., Jain, Shushant, Lynch, John M., Pavese, Nicola, Abou-Sleiman, Patrick, Holton, Janice L., ...

We have established that the frequency of LRRK2 mutations in a series of 118 cases of familial Parkinson's disease is 5.1%. In the largest family with autosomal dominant, late-onset Parkinson's...

Elevated Amyloid {beta} Protein (A{beta}42) and Late Onset Alzheimer's Disease are Associated with Single Nucleotide Polymorphisms in the Urokinase-Type Plasminogen Activator Gene (2004)

Ertekin-Taner, Nilüfer, Ronald, James, Feuk, Lars, Prince, Jonathan, Tucker, Michael, Younkin, Linda, ...

Plasma amyloid ß protein (Aß42) levels and late onset Alzheimer's disease (LOAD) have been linked to the same region on chromosome 10q. The PLAU gene within this region encodes urokinase-type...

Elevated Amyloid {beta} Protein (A{beta}42) and Late Onset Alzheimer's Disease are Associated with Single Nucleotide Polymorphisms in the Urokinase-Type Plasminogen Activator Gene (2004)

Ertekin-Taner, Nilüfer, Ronald, James, Feuk, Lars, Prince, Jonathan, Tucker, Michael, Younkin, Linda, ...

Plasma amyloid ß protein (Aß42) levels and late onset Alzheimer's disease (LOAD) have been linked to the same region on chromosome 10q. The PLAU gene within this region encodes urokinase-type...

Fine Mapping of the {alpha}-T Catenin Gene to a Quantitative Trait Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees (2003)

Ertekin-Taner, Nilüfer, Ronald, James, Asahara, Hideaki, Younkin, Linda, Hella, Maria, Jain, Shushant, ...

Using plasma amyloid ß protein (Aß42) levels as an intermediate, quantitative phenotype for late onset Alzheimer's disease (LOAD), we previously obtained significant linkage at ∼80 centimorgans...

Fine mapping of the {alpha}-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees (2003)

Ertekin-Taner, Nilüfer, Ronald, James, Asahara, Hideaki, Younkin, Linda, Hella, Maria, Jain, Shushant, ...

Using plasma amyloid β protein (Aβ42) levels as an intermediate, quantitative phenotype for late onset Alzheimer's disease (LOAD), we previously obtained significant linkage at ∼80 cM on...

Fine Mapping of the {alpha}-T Catenin Gene to a Quantitative Trait Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees (2003)

Ertekin-Taner, Nilüfer, Ronald, James, Asahara, Hideaki, Younkin, Linda, Hella, Maria, Jain, Shushant, ...

Using plasma amyloid ß protein (Aß42) levels as an intermediate, quantitative phenotype for late onset Alzheimer's disease (LOAD), we previously obtained significant linkage at ∼80 centimorgans...

Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD

Momeni, Parastoo, Schymick, Jennifer, Jain, Shushant, Cookson, Mark R, Cairns, Nigel J, Greggio, Elisa, ...

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation*S⃞

Greggio, Elisa, Zambrano, Ibardo, Kaganovich, Alice, Beilina, Alexandra, Taymans, Jean-Marc, Daniëls, Veronique, ...

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and apparently sporadic Parkinson disease. LRRK2 is a multidomain protein kinase with autophosphorylation activity. It...