The Mannose Receptor Mediates Dengue Virus Infection of Macrophages (2008)
Joanna L. Miller, Luisa Martinez-Pomares, Catherine M. Radcliffe, Raymond A. Dwek, Pauline M. Rudd, ...
Macrophages (MØ) and mononuclear phagocytes are major targets of infection by dengue virus (DV), a mosquito-borne flavivirus that can cause haemorrhagic fever in humans. To our knowledge, we show...
Griffiths, Samantha, Portman, Neil, Taylor, Philip R., Gordon, Siamon, Ginger, Michael L., Gull , Keith
We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell...
Becker, Mike, Cotena, Alessia, Gordon, Siamon, Platt, Nick
Dendritic cells (DC) function at the interface of innate and acquired immunity and are uniquely sensitive to specific stimuli. Pattern recognition receptors (PRR) on these cells are critically...
Becker, Mike, Cotena, Alessia, Gordon, Siamon, Platt, Nick
Dendritic cells (DC) function at the interface of innate and acquired immunity and are uniquely sensitive to specific stimuli. Pattern recognition receptors (PRR) on these cells are critically...
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus (2005)
Chad Steele, Rekha R. Rapaka, Allison Metz, Shannon M. Pop, David L. Williams, Siamon Gordon, ...
Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage...
Cotena, Alessia, Gordon, Siamon, Platt, Nick
The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis. In this study, we show, using a...
Nuclear and plasma membrane properties of macrophage heterokaryons and hybrids. (1971)
Thesis (Ph. D.)--Rockefeller University.
Peiser, Leanne, Gough, Peter J., Kodama, Tatsuhiko, Gordon, Siamon
Macrophage class A scavenger receptors (SR-AI and SR-AII) contribute to host defense by binding polyanionic ligands such as lipopolysaccharide and lipoteichoic acid. SR-A knockout (SR-A−/−) mice...
Káposzta, Rita, Tree, Peter, Maródi, László, Gordon, Siamon
Murine models of invasive candidiasis were used to study the in vivo importance of gamma interferon (IFN-γ) and interleukin-4 (IL-4) in host defense against Candida albicans and to characterize the...
Peiser, Leanne, Makepeace, Katherine, Hollinshead, Michael, Coull, Philip, Plested, Joyce, ...
Macrophages (Mφ) play a key role in the pathogenesis of invasive meningococcal infections. The roles of two pattern recognition molecules, the Mφ scavenger receptor (SR-A) and Toll-like receptor 4...
Inactivation of the F4/80 Glycoprotein in the Mouse Germ Line
Schaller, Evelyne, Macfarlane, Alison J., Rupec, Rudolf A., Gordon, Siamon, McKnight, Andrew J., Pfeffer, Klaus
Macrophages play a crucial role in the defense against pathogens. Distinct macrophage populations can be defined by the expression of restricted cell surface proteins. Resident tissue macrophages,...
Khati, Makobetsa, Schüman, Michael, Ibrahim, Jamal, Sattentau, Quentin, Gordon, Siamon, James, William
Human immunodeficiency virus type 1 (HIV-1) has evolved a number of strategies to resist current antiretroviral drugs and the selection pressures of humoral and cellular adaptive immunity. For...
Development of a specific system for targeting protein to metallophilic macrophages
Taylor, Philip R., Zamze, Susanne, Stillion, Richard J., Wong, Simon Y. C., Gordon, Siamon, Martinez-Pomares, Luisa
The cysteine-rich domain (CR) of the mannose receptor binds sulfated glycoprotein CR ligand (CRL) expressed by subpopulations of myeloid cells in secondary lymphoid organs (CRL+ cells). In naïve...
Cammer, Wendy, Bloom, Barry R., Norton, William T., Gordon, Siamon
In inflammatory demyelinating diseases such as multiple sclerosis and experimental allergic encephalomyelitis, myelin destruction occurs in the vicinity of infiltrating mononuclear cells. The...
Cheung, Chung Y., Poon, Leo L. M., Ng, Iris H. Y., Luk, Winsie, Sia, Sin-Fun, Wu, Mavis H. S., ...
The pathogenesis of severe acute respiratory syndrome (SARS) remains unclear. Macrophages are key sentinel cells in the respiratory system, and it is therefore relevant to compare the responses of...
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus
Steele, Chad, Rapaka, Rekha R, Metz, Allison, Pop, Shannon M, Williams, David L, Gordon, Siamon, ...
Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage...
Peiser, Leanne, Gough, Peter J., Kodama, Tatsuhiko, Gordon, Siamon
Macrophage class A scavenger receptors (SR-AI and SR-AII) contribute to host defense by binding polyanionic ligands such as lipopolysaccharide and lipoteichoic acid. SR-A knockout (SR-A−/−) mice...
Káposzta, Rita, Tree, Peter, Maródi, László, Gordon, Siamon
Murine models of invasive candidiasis were used to study the in vivo importance of gamma interferon (IFN-γ) and interleukin-4 (IL-4) in host defense against Candida albicans and to characterize the...
Peiser, Leanne, Makepeace, Katherine, Hollinshead, Michael, Coull, Philip, Plested, Joyce, ...
Macrophages (Mφ) play a key role in the pathogenesis of invasive meningococcal infections. The roles of two pattern recognition molecules, the Mφ scavenger receptor (SR-A) and Toll-like receptor 4...
Inactivation of the F4/80 Glycoprotein in the Mouse Germ Line
Schaller, Evelyne, Macfarlane, Alison J., Rupec, Rudolf A., Gordon, Siamon, McKnight, Andrew J., Pfeffer, Klaus
Macrophages play a crucial role in the defense against pathogens. Distinct macrophage populations can be defined by the expression of restricted cell surface proteins. Resident tissue macrophages,...
Khati, Makobetsa, Schüman, Michael, Ibrahim, Jamal, Sattentau, Quentin, Gordon, Siamon, James, William
Human immunodeficiency virus type 1 (HIV-1) has evolved a number of strategies to resist current antiretroviral drugs and the selection pressures of humoral and cellular adaptive immunity. For...
Development of a specific system for targeting protein to metallophilic macrophages
Taylor, Philip R., Zamze, Susanne, Stillion, Richard J., Wong, Simon Y. C., Gordon, Siamon, Martinez-Pomares, Luisa
The cysteine-rich domain (CR) of the mannose receptor binds sulfated glycoprotein CR ligand (CRL) expressed by subpopulations of myeloid cells in secondary lymphoid organs (CRL+ cells). In naïve...
Cammer, Wendy, Bloom, Barry R., Norton, William T., Gordon, Siamon
In inflammatory demyelinating diseases such as multiple sclerosis and experimental allergic encephalomyelitis, myelin destruction occurs in the vicinity of infiltrating mononuclear cells. The...
Cheung, Chung Y., Poon, Leo L. M., Ng, Iris H. Y., Luk, Winsie, Sia, Sin-Fun, Wu, Mavis H. S., ...
The pathogenesis of severe acute respiratory syndrome (SARS) remains unclear. Macrophages are key sentinel cells in the respiratory system, and it is therefore relevant to compare the responses of...
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus
Steele, Chad, Rapaka, Rekha R, Metz, Allison, Pop, Shannon M, Williams, David L, Gordon, Siamon, ...
Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage...
Peiser, Leanne, Makepeace, Katherine, Plüddemann, Annette, Savino, Silvana, Wright, J. Claire, Pizza, Mariagrazia, ...
Macrophages (Mφ) may play an important role in the pathogenesis of invasive meningococcal infection. Previously, we have shown that the class A Mφ scavenger receptor (SR-A) is a major nonopsonic...
Macrophage heterogeneity and tissue lipids
Macrophages are present as resident cells in adipose tissue, and blood monocytes are recruited in increased numbers to sites of lipid accumulation in atherosclerosis, a modified form of inflammation...
The potential for Toll-like receptors to collaborate with other innate immune receptors
Mukhopadhyay, Subhankar, Herre, Jurgen, Brown, Gordon D, Gordon, Siamon
Cells of the innate immune system express a large repertoire of germ-line encoded cell-surface glycoprotein receptors including Toll-like receptors (TLRs). TLRs recognize conserved motifs on microbes...
Gough, Peter J, Gordon, Siamon, Greaves, David R
Macrophages (Mφ) play a key role in innate and acquired immunity. The study of Mφ biology has been hampered by the absence of suitable gene regulatory sequences for the overexpression of...
Lucas, Andrew D., Chadwick, Nicholas, Warren, Bryan F., Jewell, Derek P., Gordon, Siamon, Powrie, Fiona, ...
Fractalkine (CX3CL1) is synthesized as a type I transmembrane protein. Its unique CX3C chemokine domain is attached to a 241-amino acid mucin stalk, a 19-amino acid transmembrane domain, and a...
Griffiths, Samantha, Portman, Neil, Taylor, Philip R., Gordon, Siamon, Ginger, Michael L., Gull, Keith
We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell...
Impaired phagocytic mechanism in annexin 1 null macrophages
Yona, Simon, Heinsbroek, Sigrid E M, Peiser, Leanne, Gordon, Siamon, Perretti, Mauro, Flower, Roderick J
The role of the anti-inflammatory protein annexin-A1 (Anx-A1) in the phagocytic process has been investigated using a murine bone marrow culture-derived macrophage model from Anx-A1+/+ and...
Bhakta, Sanjib, Besra, Gurdyal S., Upton, Anna M., Parish, Tanya, Gibson, Kevin J.C., ...
Mycolic acids represent a major component of the unique cell wall of mycobacteria. Mycolic acid biosynthesis is inhibited by isoniazid, a key frontline antitubercular drug that is inactivated by...
Lin, Hsi-Hsien, Faunce, Douglas E., Stacey, Martin, Terajewicz, Ania, Nakamura, Takahiko, Zhang-Hoover, Jie, ...
We show that the mouse macrophage-restricted F4/80 protein is not required for the development and distribution of tissue macrophages but is involved in the generation of antigen-specific efferent...
Yoshitomi, Hiroyuki, Sakaguchi, Noriko, Kobayashi, Katsuya, Brown, Gordon D., Tagami, Tomoyuki, Sakihama, Toshiko, ...
A combination of genetic and environmental factors can cause autoimmune disease in animals. SKG mice, which are genetically prone to develop autoimmune arthritis, fail to develop the disease under a...
Morris, Lynn, Crocker, Paul R., Hill, Maxine, Gordon, Siamon
Stromal macrophages in lymphohemopoietic tissues express novel macrophagerestricted plasma membrane receptors involved in nonphagocytic interactions with other hemopoietic cells. One such receptor...
Dectin-1 Is A Major β-Glucan Receptor On Macrophages
Brown, Gordon D., Taylor, Philip R., Reid, Delyth M., Willment, Janet A., Williams, David L., Martinez-Pomares, Luisa, ...
Zymosan is a β-glucan– and mannan-rich particle that is widely used as a cellular activator for examining the numerous responses effected by phagocytes. The macrophage mannose receptor (MR) and...
Dectin-1 Mediates the Biological Effects of β-Glucans
Brown, Gordon D., Herre, Jurgen, Williams, David L., Willment, Janet A., Marshall, Andrew S. J., Gordon, Siamon
The ability of fungal-derived β-glucan particles to induce leukocyte activation and the production of inflammatory mediators, such as tumor necrosis factor (TNF)-α, is a well characterized...
Steele, Chad, Marrero, Luis, Swain, Steve, Harmsen, Allen G., Zheng, Mingquan, Brown, Gordon D., ...
Innate immune mechanisms against Pneumocystis carinii, a frequent cause of pneumonia in immunocompromised individuals, are not well understood. Using both real time polymerase chain reaction as a...
Linehan, Sheena A., Martínez-Pomares, Luisa, Stahl, Philip D., Gordon, Siamon
The mannose receptor (MR) has established roles in macrophage (Mφ) phagocytosis of microorganisms and endocytic clearance of host-derived glycoproteins, and has recently been implicated in antigen...
Berney, Claude, Herren, Suzanne, Power, Christine A., Gordon, Siamon, Martinez-Pomares, Luisa, Kosco-Vilbois, Marie H.
Dendritic cells (DCs) are known to activate naive T cells to become effective helper cells. In addition, recent evidence suggests that DCs may influence naive B cells during the initial priming of...
Greaves, David R., Wang, Wei, Dairaghi, Daniel J., Dieu, Marie Caroline, Saint-Vis, Blandine De, Franz-Bacon, Karin, ...
Dendritic cells initiate immune responses by ferrying antigen from the tissues to the lymphoid organs for presentation to lymphocytes. Little is known about the molecular mechanisms underlying this...
Haworth, Richard, Platt, Nick, Keshav, Satish, Hughes, Derralynn, Darley, Elisabeth, Suzuki, Hiroshi, ...
During gram-negative bacterial infections, lipopolysaccharide (LPS) stimulates primed macrophages (Mφ) to release inflammatory mediators such as tumor necrosis factor (TNF)-α, which can cause...
The Mannose Receptor Mediates Dengue Virus Infection of Macrophages
Miller, Joanna L, DeWet, Barend J. M, Martinez-Pomares, Luisa, Radcliffe, Catherine M, Dwek, Raymond A, Rudd, Pauline M, ...
Macrophages (MØ) and mononuclear phagocytes are major targets of infection by dengue virus (DV), a mosquito-borne flavivirus that can cause haemorrhagic fever in humans. To our knowledge, we show...
Wreschner, Daniel H., McGuckin, Michael A., Williams, Stefanie J., Baruch, Amos, Yoeli, Merav, Ziv, Ravit, ...
A mechanism is described whereby one and the same gene can encode both a receptor protein as well as its specific ligand. Generation of this receptor–ligand partnership is effected by proteolytic...
Structure of the fungal β-glucan-binding immune receptor dectin-1: Implications for function
Brown, James, O'Callaghan, Chris A., Marshall, Andrew S.J., Gilbert, Robert J.C., Siebold, Christian, Gordon, Siamon, ...
The murine molecule dectin-1 (known as the β-glucan receptor in humans) is an immune cell surface receptor implicated in the immunological defense against fungal pathogens. Sequence analysis has...
Correction: The Mannose Receptor Mediates Dengue Virus Infection of Macrophages
Miller, Joanna L, Martinez-Pomares, Luisa, Radcliffe, Catherine M, Dwek, Raymond A, Rudd, Pauline M, ...
Stage-Specific Sampling by Pattern Recognition Receptors during Candida albicans Phagocytosis
Heinsbroek, Sigrid E. M., Taylor, Philip R., Martinez, Fernando O., Martinez-Pomares, Luisa, Brown, Gordon D., Gordon, Siamon
Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be...