Sian Floyd

Differences between naive and memory T cell phenotype in Malawian and UK adolescents: a role for Cytomegalovirus? (2008)

Ben-Smith, Anne, Gorak-Stolinska, Patricia, Floyd, Sian, Weir, Rosemary E, Lalor, Maeve K, Mvula, Hazzie, ...

Abstract Background Differences in degree of environmental exposure to antigens in early life have been hypothesized to lead to differences in immune status in individuals from different populations,...

Persistence of the immune response induced by BCG vaccination (2008)

Weir, Rosemary E, Gorak-Stolinska, Patricia, Floyd, Sian, Lalor, Maeve K, Stenson, Sally, Branson, Keith, ...

Abstract Background Although BCG vaccination is recommended in most countries of the world, little is known of the persistence of BCG-induced immune responses. As novel TB vaccines may be given to...

The long-term impact of HIV and orphanhood on the mortality and physical well-being of children in rural Malawi (2003)

Crampin, Amelia C., Floyd, Sian, Glynn, Judith R., Madise, Nyovani, Nyondo, Andrew, Khondowe, Masiya M., ...

Objective: To assess the influence of maternal HIV status and orphanhood on child mortality and physical well-being. Design: Retrospective cohort study with > 10 years of follow-up. Methods: From...

Gamma Interferon Responses Induced by a Panel of Recombinant and Purified Mycobacterial Antigens in Healthy, Non-Mycobacterium bovis BCG-Vaccinated Malawian Young Adults

Black, Gillian F., Weir, Rosemary E., Chaguluka, Steven D., Warndorff, David, Crampin, Amelia C., Mwaungulu, Lorren, ...

We have previously shown that young adults living in a rural area of northern Malawi showed greater gamma interferon (IFN-γ) responses to purified protein derivatives (PPD) prepared from...

Mycobacterial Purified Protein Derivatives Stimulate Innate Immunity: Malawians Show Enhanced Tumor Necrosis Factor Alpha, Interleukin-1β (IL-1β), and IL-10 Responses Compared to Those of Adolescents in the United Kingdom

Weir, Rosemary E., Black, Gillian F., Dockrell, Hazel M., Floyd, Sian, Fine, Paul E. M., Chaguluka, Steven D., ...

To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1β...

Distribution of Environmental Mycobacteria in Karonga District, Northern Malawi

Chilima, Benson Z., Clark, Ian M., Floyd, Sian, Fine, Paul E. M., Hirsch, Penny R.

The genus Mycobacterium includes many species that are commonly found in the environment (in soil and water or associated with plants and animals), as well as species that are responsible for two...

Gamma Interferon Responses Induced by a Panel of Recombinant and Purified Mycobacterial Antigens in Healthy, Non-Mycobacterium bovis BCG-Vaccinated Malawian Young Adults

Black, Gillian F., Weir, Rosemary E., Chaguluka, Steven D., Warndorff, David, Crampin, Amelia C., Mwaungulu, Lorren, ...

We have previously shown that young adults living in a rural area of northern Malawi showed greater gamma interferon (IFN-γ) responses to purified protein derivatives (PPD) prepared from...

Mycobacterial Purified Protein Derivatives Stimulate Innate Immunity: Malawians Show Enhanced Tumor Necrosis Factor Alpha, Interleukin-1β (IL-1β), and IL-10 Responses Compared to Those of Adolescents in the United Kingdom

Weir, Rosemary E., Black, Gillian F., Dockrell, Hazel M., Floyd, Sian, Fine, Paul E. M., Chaguluka, Steven D., ...

To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1β...

Distribution of Environmental Mycobacteria in Karonga District, Northern Malawi

Chilima, Benson Z., Clark, Ian M., Floyd, Sian, Fine, Paul E. M., Hirsch, Penny R.

The genus Mycobacterium includes many species that are commonly found in the environment (in soil and water or associated with plants and animals), as well as species that are responsible for two...

CD209 Genetic Polymorphism and Tuberculosis Disease

Vannberg, Fredrik O., Chapman, Stephen J., Khor, Chiea C., Tosh, Kerrie, Floyd, Sian, Jackson-Sillah, Dolly, ...

Persistence of the immune response induced by BCG vaccination

Weir, Rosemary E, Gorak-Stolinska, Patricia, Floyd, Sian, Lalor, Maeve K, Stenson, Sally, Branson, Keith, ...

The effects of high HIV prevalence on orphanhood and living arrangements of children in Malawi, Tanzania, and South Africa

Hosegood, Victoria, Floyd, Sian, Marston, Milly, Hill, Caterina, McGrath, Nuala, Isingo, Raphael, ...

Using longitudinal data from three demographic surveillance systems (DSS) and a retrospective cohort study, we estimate levels and trends in the prevalence and incidence of orphanhood in South...

Population-level effect of HIV on adult mortality and early evidence of reversal after introduction of antiretroviral therapy in Malawi

Jahn, Andreas, Floyd, Sian, Crampin, Amelia C, Mwaungulu, Frank, Mvula, Hazzie, Munthali, Fipson, ...

Implication of New WHO Growth Standards on Identification of Risk Factors and Estimated Prevalence of Malnutrition in Rural Malawian Infants

Prost, Marc-André, Jahn, Andreas, Floyd, Sian, Mvula, Hazzie, Mwaiyeghele, Eleneus, Mwinuka, Venance, ...

Differences between naive and memory T cell phenotype in Malawian and UK adolescents: a role for Cytomegalovirus?

Ben-Smith, Anne, Gorak-Stolinska, Patricia, Floyd, Sian, Weir, Rosemary E, Lalor, Maeve K, Mvula, Hazzie, ...

Cotrimoxazole prophylaxis reduces mortality in human immunodeficiency virus-positive tuberculosis patients in Karonga District, Malawi.

Mwaungulu, Frank B. D., Floyd, Sian, Crampin, Amelia C., Kasimba, Simplex, Malema, Simon, Kanyongoloka, Huxley, ...

OBJECTIVE: To estimate the impact of cotrimoxazole prophylaxis on the survival of human immunodeficiency virus (HIV)-positive tuberculosis (TB) patients. METHODS: A cohort study with a historical...