Sic L. Chan

Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke (2009)

Lathia, Justin D., Chigurupati, Srinivasulu, Thundyil, John, Selvaraj, Pradeep K., Mughal, Mohamed R., Woodruff, Trent M., ...

[beta]1 integrin is a cell surface molecule that is critical for endothelial cell adhesion, migration and survival during angiogenesis. In the present study we employed in vivo and in vitro models to...

Lysosome-related generation of potentially amyloidogenic serum amyloid A polypeptides in activated murine macrophages and the potential role of ubiquitin in this process (1997)

Chan, Sic L.

Reactive amyloidosis characterized by the tissue deposition of insoluble AA amyloid (AA), is a potentially serious complication of certain chronic infections and recurrent inflammatory diseases. AA...

Lysosome-related generation of potentially amyloidogenic serum amyloid A polypeptides in activated murine macrophages and the potential role of ubiquitin in this process (1997)

Chan, Sic L.

Reactive amyloidosis characterized by the tissue deposition of insoluble AA amyloid (AA), is a potentially serious complication of certain chronic infections and recurrent inflammatory diseases. AA...

Involvement of Notch signaling in hippocampal synaptic plasticity

Wang, Yue, Chan, Sic L., Miele, Lucio, Yao, Pamela J., Mackes, Jennifer, Ingram, Donald K., ...

During development of the nervous system, the fate of stem cells is regulated by a cell surface receptor called Notch. Notch is also present in the adult mammalian brain; however, because Notch null...

Involvement of Notch signaling in hippocampal synaptic plasticity

Wang, Yue, Chan, Sic L., Miele, Lucio, Yao, Pamela J., Mackes, Jennifer, Ingram, Donald K., ...

During development of the nervous system, the fate of stem cells is regulated by a cell surface receptor called Notch. Notch is also present in the adult mammalian brain; however, because Notch null...

Evidence that Par-4 Participates in the Pathogenesis of HIV Encephalitis

Kruman, Inna I., Nath, Avindra, Maragos, William F., Chan, Sic L., Jones, Melina, Rangnekar, Vivek M., ...

Progressive neuronal degeneration in brain regions involved in learning and memory processes is a common occurrence in patients infected with human immunodeficiency virus type 1 (HIV-1). We now...

Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death

Arumugam, Thiruma V., Tang, Sung-Chun, Lathia, Justin D., Cheng, Aiwu, Mughal, Mohamed R., Chigurupati, Srinivasulu, ...

Stroke is among the three leading causes of death worldwide and the most frequent cause of permanent disability. Brain ischemia induces an inflammatory response involving activated complement...

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

Jang, Hyeung-Jin, Kokrashvili, Zaza, Theodorakis, Michael J., Carlson, Olga D., Kim, Byung-Joon, Zhou, Jie, ...

Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically,...

Numb Endocytic Adapter Proteins Regulate the Transport and Processing of the Amyloid Precursor Protein in an Isoform-dependent Manner: IMPLICATIONS FOR ALZHEIMER DISEASE PATHOGENESIS*S⃞

Kyriazis, George A., Wei, Zelan, Vandermey, Miriam, Jo, Dong-Gyu, Xin, Ouyang, Mattson, Mark P., ...

Central to the pathogenesis of Alzheimer disease is the aberrant processing of the amyloid precursor protein (APP) to generate amyloid β-peptide (Aβ), the principle component of amyloid plaques....