Roy, Siddhartha, Saraswathi, Ramachandran, Gupta, Surbhi, Sekar, K, Chatterji, Dipankar, Vijayan, M
Mycobacterium smegmatis Dps degrades spontaneously into a species in which 16 C-terminal residues are cleaved away. A second species, in which all 26 residues constituting the tail were deleted, was...
Specific Inhibition of p300-HAT Alters Global Gene Expression and Represses HIV Replication (2007)
Mantelingu, K, Reddy, Ashok BA, Swaminathan, V, Kishore, Hari A, Siddappa, Nagadenahalli B, Kumar, Pavan GV, ...
Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer,...
Selvaraj, M, Thamotharan, S, Roy, Siddhartha, Vijayan, M
The tartaric acid complexes with arginine and lysine exhibit two stoichiometries depending upon the ionization state of the anion. The structures reported here are $DL$-argininium $DL$hydrogen...
Roy, Siddhartha, Saraswathi, Ramachandran, Gupta, Surbhi, Sekar, K, Chatterji, Dipankar, Vijayan, M
Mycobacterium smegmatis Dps degrades spontaneously into a species in which 16 C-terminal residues are cleaved away. A second species, in which all 26 residues constituting the tail were deleted, was...
Specific Inhibition of p300-HAT Alters Global Gene Expression and Represses HIV Replication (2007)
Mantelingu, K, Reddy, Ashok BA, Swaminathan, V, Kishore, Hari A, Siddappa, Nagadenahalli B, Kumar, Pavan GV, ...
Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer,...
Selvaraj, M, Thamotharan, S, Roy, Siddhartha, Vijayan, M
The tartaric acid complexes with arginine and lysine exhibit two stoichiometries depending upon the ionization state of the anion. The structures reported here are $DL$-argininium $DL$hydrogen...
Selvaraj, M, Singh, NS, Roy, Siddhartha, Sangeetha, R, Varshney, Umesh, Vijayan, M
Peptidyl-tRNA hydrolase catalyses the cleavage of the ester link between the peptide and the tRNA in peptidyl-tRNAs that, for various reasons, have dropped off the translating ribosomes. This enzyme...
Sharma, Alok, Thamotharan, S, Roy, Siddhartha, Vijayan, M
The asymmetric unit of the DL-lysine complex of adipic acid [bis(DL-lysinium) adipate], $2C_6H_1_5N_2O_2^+·C_6H_8O_4^2^-$, contains a zwitterionic singly charged lysinium cation and half a doubly...
Sharma, Alok, Thamotharan, S, Roy, Siddhartha, Vijayan, M
The asymmetric unit of the DL-lysine complex of adipic acid [bis(DL-lysinium) adipate], $2C_6H_1_5N_2O_2^+·C_6H_8O_4^2^-$, contains a zwitterionic singly charged lysinium cation and half a doubly...
Selvaraj, M, Singh, NS, Roy, Siddhartha, Sangeetha, R, Varshney, Umesh, Vijayan, M
Peptidyl-tRNA hydrolase catalyses the cleavage of the ester link between the peptide and the tRNA in peptidyl-tRNAs that, for various reasons, have dropped off the translating ribosomes. This enzyme...
Roy, Siddhartha, Singh, Desh Deepak, Vijayan, M
The adipic acid complexes of DL-arginine and L-arginine are made up of zwitterionic, singularly positively charged arginium ions and doubly negatively charged adipate ions, with a 2:1 stoichiometry....
Roy, Siddhartha, Singh, Desh Deepak, Vijayan, M
The adipic acid complexes of DL-arginine and L-arginine are made up of zwitterionic, singularly positively charged arginium ions and doubly negatively charged adipate ions, with a 2:1 stoichiometry....
Roy, Siddhartha, Gupta, Surbhi, Das, Satyabrata, Sekar, K, Chatterji, Dipankar, Vijayan, M
The structure of the DNA binding protein from starved cells from Mycobacterium smegmatis has been determined in three crystal forms and has been compared with those of similar proteins from other...
Roy, Siddhartha, Gupta, Surbhi, Das, Satyabrata, Sekar, K, Chatterji, Dipankar, Vijayan, M
The structure of the DNA binding protein from starved cells from Mycobacterium smegmatis has been determined in three crystal forms and has been compared with those of similar proteins from other...
Crystallization and preliminary X-ray diffraction analysis of Mycobacterium smegmatis Dps (2003)
Roy, Siddhartha, Gupta, Surbhi, Das, Surbhi, Sekar, K, Chatterji, Dipankar, Vijayan, M
Three crystal forms of a DNA-binding protein from stationary phase cells (Dps) of Mycobacterium smegmatis have been grown. They are hexagonal, tetragonal and cubic. The structure of the cubic form,...
Saraswathi, NT, Roy, Siddhartha, Vijayan, M
The complexes of l-arginine and dl-lysine with pimelic acid are made up of singly positively charged zwitterionic amino acid cations and doubly negatively charged pimelate ions in a 2:1 ratio. In...
Crystallization and preliminary X-ray diffraction analysis of Mycobacterium smegmatis Dps (2003)
Roy, Siddhartha, Gupta, Surbhi, Das, Surbhi, Sekar, K, Chatterji, Dipankar, Vijayan, M
Three crystal forms of a DNA-binding protein from stationary phase cells (Dps) of Mycobacterium smegmatis have been grown. They are hexagonal, tetragonal and cubic. The structure of the cubic form,...
Saraswathi, NT, Roy, Siddhartha, Vijayan, M
The complexes of l-arginine and dl-lysine with pimelic acid are made up of singly positively charged zwitterionic amino acid cations and doubly negatively charged pimelate ions in a 2:1 ratio. In...
Stochastic Simulation of Gene Expression in a Single Cell (2002)
Bose, Indrani, Karmakar, Rajesh, Roy, Siddhartha
In this paper, we consider two stochastic models of gene expression in prokaryotic cells. In the first model, sixteen biochemical reactions involved in transcription, translation and transcriptional...
A Cooperative Stochastic Model of Gene Expression (2001)
Roy, Siddhartha, Bose, Indrani, Manna, Subhrangshu Sekhar
Recent experiments at the level of a single cell have shown that gene expression occurs in abrupt stochastic bursts. Further, in an ensemble of cells, the levels of proteins produced have a bimodal...
The generalized M/G/C queue :--an implementation with some results /--Siddhartha Roy. (1992)
Thesis (M.S.)--University of Connecticut, 1992.
Typescript (photocopy).
Typescript (photocopy).
Chatterjee, Sumana, Zhou, Yan-Ning, Roy, Siddhartha, Adhya, Sankar
Gal repressor inhibits transcription from the gal promoter (P1) when it binds to the cognate operator (OE). The repression is relieved by the presence of the inducer d-galactose. Compared with its...
A “master” in base unpairing during isomerization of a promoter upon RNA polymerase binding
Lim, Heon Man, Lee, Hee Jung, Roy, Siddhartha, Adhya, Sankar
Isomerization of a closed to open complex of a promoter upon RNA polymerase binding involves base unpairing at the −10 region. After potassium permanganate sensitivity of unpaired thymine residues,...
Solvation change and ion release during aminoacylation by aminoacyl-tRNA synthetases
Banerjee, Rajat, Mandal, Amit Kumar, Saha, Rajesh, Guha, Soumi, Samaddar, Soma, Bhattacharyya, Anusree, ...
Discrimination between cognate and non-cognate tRNAs by aminoacyl-tRNA synthetases occurs at several steps of the aminoacylation pathway. We have measured changes of solvation and counter-ion...
Asynchronous basepair openings in transcription initiation: CRP enhances the rate-limiting step
Roy, Siddhartha, Lim, Heon Man, Liu, Mofang, Adhya, Sankar
The mechanism of isomerization (basepair openings) during transcription initiation by RNA polymerase at the galP1 promoter of Escherichia coli was investigated by 2-aminopurine (2,AP) fluorescence....
Switching DNA-binding specificity by unnatural amino acid substitution
The specificity of protein–nucleic acid recognition is believed to originate largely from hydrogen bonding between protein polar atoms, primarily side-chain and polar atoms of nucleic acid bases....
Saha, Abhik, Sharma, Archna, Dhar, Amlanjyoti, Bhattacharyya, Bhabatarak, Roy, Siddhartha, Das Gupta, Sujoy K.
The persistence of Mycobacterium tuberculosis is a major cause of concern in tuberculosis (TB) therapy. In the persistent mode the pathogen can resist drug therapy, allowing the possibility of...
Chatterjee, Sumana, Zhou, Yan-Ning, Roy, Siddhartha, Adhya, Sankar
Gal repressor inhibits transcription from the gal promoter (P1) when it binds to the cognate operator (OE). The repression is relieved by the presence of the inducer d-galactose. Compared with its...
A “master” in base unpairing during isomerization of a promoter upon RNA polymerase binding
Lim, Heon Man, Lee, Hee Jung, Roy, Siddhartha, Adhya, Sankar
Isomerization of a closed to open complex of a promoter upon RNA polymerase binding involves base unpairing at the −10 region. After potassium permanganate sensitivity of unpaired thymine residues,...
Solvation change and ion release during aminoacylation by aminoacyl-tRNA synthetases
Banerjee, Rajat, Mandal, Amit Kumar, Saha, Rajesh, Guha, Soumi, Samaddar, Soma, Bhattacharyya, Anusree, ...
Discrimination between cognate and non-cognate tRNAs by aminoacyl-tRNA synthetases occurs at several steps of the aminoacylation pathway. We have measured changes of solvation and counter-ion...
Asynchronous basepair openings in transcription initiation: CRP enhances the rate-limiting step
Roy, Siddhartha, Lim, Heon Man, Liu, Mofang, Adhya, Sankar
The mechanism of isomerization (basepair openings) during transcription initiation by RNA polymerase at the galP1 promoter of Escherichia coli was investigated by 2-aminopurine (2,AP) fluorescence....
Switching DNA-binding specificity by unnatural amino acid substitution
The specificity of protein–nucleic acid recognition is believed to originate largely from hydrogen bonding between protein polar atoms, primarily side-chain and polar atoms of nucleic acid bases....
Saha, Abhik, Sharma, Archna, Dhar, Amlanjyoti, Bhattacharyya, Bhabatarak, Roy, Siddhartha, Das Gupta, Sujoy K.
The persistence of Mycobacterium tuberculosis is a major cause of concern in tuberculosis (TB) therapy. In the persistent mode the pathogen can resist drug therapy, allowing the possibility of...
Selvaraj, M., Singh, N. S., Roy, Siddhartha, Sangeetha, R., Varshney, Umesh, Vijayan, M.
The peptidyl-tRNA hydrolase from M. tuberculosis has been crystallized in three closely related forms, two orthorhombic and one monoclinic, and X-ray diffraction data have been collected from them.