Sidney D. Nelson

Nrf2 Activation Involves An Oxidative-Stress Independent Pathway In Tetrafluoroethylcysteine-Induced Cytotoxicity (2005)

Ho, Han K., White, Collin C., Fernandez, Carolina, Fausto, Nelson, Kavanagh, Terrance J., Nelson, Sidney D., ...

Tetrafluoroethylcysteine (TFEC), a metabolite of the industrial gas tetrafluoroethylene, can cause both nephrotoxicity and limited hepatotoxicity in animal models and this is associated with the...

Nrf2 Activation Involves an Oxidative-Stress Independent Pathway in Tetrafluoroethylcysteine-Induced Cytotoxicity (2005)

Ho, Han K., White, Collin C., Fernandez, Carolina, Fausto, Nelson, Kavanagh, Terrance J., Nelson, Sidney D., ...

Tetrafluoroethylcysteine (TFEC), a metabolite of the industrial gas tetrafluoroethylene, can cause both nephrotoxicity and limited hepatotoxicity in animal models, and this is associated with the...

Deuterium Isotope Effect on the Metabolism of the Flame Retardant Tris(2,3-dibromopropyl) Phosphate in the Isolated Perfused Rat Liver (1995)

PEARSON, PAUL G., MEIJER, DIRK K. F., MULDER, GERARD J., NELSON, SIDNEY D., MEERMAN, JOHN H. N.

The metabolism of tris(2,3-dibromopropyl) phosphate (Tris-BP) was compared with that of completely deuterated Tris-BP (D15-Tris-BP) in an isolated, recirculating rat liver perfusion system in order...

Genotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate in the rat and Drosophila: effects of deuterium substitution (1994)

Nivard, Madeleine J.M., Vogel, Ekkehart W., Nelson, Sidney D., Meerman, John H.N.

Formation of 2-bromoacrolein (2BA) from tris(2,3-dibromo- propyl)phosphate (Tris-BP) by cytochrome P450 (cyt. P450) activity is most likely responsible for the high mutagenicity of Tris-BP for...

Formation of thymidine adducts and cross-linking potential of 2-bromoacrolein, a reactive metabolite of tris(2,3-dibromopropyl)phosphate (1992)

Nivard, Madeleine J.M., Vogel, Ekkehart W., Nelson, Sidney D., Meerman, John H.N.

DNA-adduct formation by the mutagen 2-bromoacrolein (2BA) with DNA was studied. [3-3H]2BA was reacted with single-stranded (ss) DNA or double-stranded (ds) DNA and subsequently incubated with...

Co-culture systems for assessing the stability and genotoxicity of reactive 1, 2-dibromo-3-chloropropane (DBCP) metabolites (1991)

Søderlund, Erik J., Brunborg, Gunnar, Holme, Jørn A., Hongslo, Jan K., Nelson, Sidney D., Dybing, Erik

1, 2-Dibromo-3-choloropropane (DBCP) induced DNA damage, measured by alkaline elution, at low concentrations (5–10μM) in suspensions of hepatocytes and testicular cells isolated from rats. At...

Different mechanisms are involved in DNA damage, bacterial mutagenicity and cytotoxicity induced by 1,2-dibromo-3-chloropropane in suspensions of rat liver cells (1989)

Holme, Jørn A., Søderlund, Erik J., Brunborg, Gunnar, Omichinski, James G., Bekkedal, Kirsti, Trygg, Bente, ...

1,2-Dibromo-3-chloropropane (DBCP) induced DNA damage, measured by an automated alkaline elution method, in suspensions of rat liver parenchymal cells at low concentrations (1–10 μM). At much...

Comparative genotoxicities of procarbazine and two deuterated analogs in mammalian cells in vitro and in vivo (1989)

Holme, Jørn A., Søderlund, Erik J., Brunborg, Gunnar, Hongslo, Jan K., Trygg, Bente, Nelson, Sidney D.

N-isopropyl-α-(2-methylhydrazino)-p-toluamide hydro-chloride (procarbazine; 50–1000 μg/ml) induced DNA damage in hepatocytes measured by an automated alkaline elution method, whereas no...

Toxic effects of paracetamol and related structures in V79 Chinese hamster cells (1988)

Holme, Jørn A., Hongslo, Jan K., Bjørnstad, Christine, Harvison, Peter J., Nelson, Sidney D.

Exposure of V79 Chinese hamster cells to non-cytotoxic concentrations of paracetamol (4-hydroxyacetanilide, 4-HAA) increased sister chromatid exchange (SCE) in the absence of an external activation...

Synthesis and mutagenicity of selectively methylated analogs of tris(2,3-dibromopropyl)phosphate and 1,2-dibromo-3-chloropropane (1987)

Omichinski, James G., Søderlund, Erik J., Bausano, James A., Dybing, Erik, Nelson, Sidney D.

Five selectively methylated analogs of the flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) and of the nematocide 1,2-dibromo-3-chloropropane (DBCP) were synthesized and their relative...

The genotoxicity of 2-bromoacrolein and 2,3-dibromopropanal (1985)

Gordon, W. Perry, Sderlund, Erik J., Holme, Jorn A., Nelson, Sidney D., Iyer, Lokanathan, Rivedal, Edgar, ...

2-Bromoacrolem (2-BA) and 2,3-dibromopropanal (2,3- DBPA), an identified and a postulated reactive metabolite of tris(2,3-dlbromopropyl)phosphate (Tris-BP), respectively, were found to cause...

Species Differences in Kidney Toxicitity and Metabolic Activation of Tris(2,3-dibromopropyl)phosphate* (1982)

SØDERLUND, ERIK J., NELSON, SIDNEY D., VON BAHR, CHRISTER, DYBING, ERIK

Species Differences in Kidney Toxicity and Metabolic Activation of Tris(2,3-dibromopropyl)phosphate. Sπderlund, E.J., Nelson, S.D., von Bahr, C. and Dybing, E. Fundam. Appl. Toxicol. 2:187-194. The...

Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites

Senter, Peter D., Al-Abed, Yousef, Metz, Christine N., Benigni, Fabio, Mitchell, Robert A., Chesney, J., ...

The cytokine macrophage migration inhibitory factor (MIF) has emerged to be an important regulator of the inflammatory response and is critically involved in the development of septic shock,...

Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites

Senter, Peter D., Al-Abed, Yousef, Metz, Christine N., Benigni, Fabio, Mitchell, Robert A., Chesney, J., ...

The cytokine macrophage migration inhibitory factor (MIF) has emerged to be an important regulator of the inflammatory response and is critically involved in the development of septic shock,...