Siegfried Morath

Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis (2008)

Kramer, Naomi E., Hasper, Hester E., Morath, Siegfried, Kruijff, Ben De, Hartung, Thomas, ...

Nisin is a post-translationally modified antimicrobial peptide produced by Lactococcus lactis which binds to lipid II in the membrane to form pores and inhibit cell-wall synthesis. A nisin-resistant...

β-lactam antibiotic-induced release of lipoteichoic acid from Staphylococcus aureusleads to activation of neutrophil granulocytes (2006)

Lotz, Sonja, Starke, Andrea, Ziemann, Christian, Morath, Siegfried, Hartung, Thomas, Solbach, Werner, ...

Abstract Background Polymorphonuclear neutrophil granulocytes (PMN) are phagocytes of the first line of antimicrobial defense. Previously we demonstrated that lipoteichoic acid (LTA) from...

Highly purified lipoteichoic acid from Staphylococcus aureus induces procoagulant activity and tissue factor expression in human monocytes but is a weak inducer in whole blood: Comparison with peptidoglycan (2004)

Mattsson, Eva, Hartung, Thomas, Morath, Siegfried, Egesten, Arne

Lipoteichoic acid from Staphylococcus aureus was a potent inducer of procoagulant activity in isolated mononuclear cells but not in whole blood. In contrast, staphylococcal peptidoglycan showed equal...

Structural Decomposition and Heterogeneity of Commercial Lipoteichoic Acid Preparations

Morath, Siegfried, Geyer, Armin, Spreitzer, Ingo, Hermann, Corinna, Hartung, Thomas

Fractionation of commercial preparations of lipoteichoic acids (LTA) by hydrophobic interaction chromatography (HIC) and nuclear magnetic resonance spectroscopy revealed very inhomogeneous...

Highly Purified Lipoteichoic Acid from Staphylococcus aureus Induces Procoagulant Activity and Tissue Factor Expression in Human Monocytes but Is a Weak Inducer in Whole Blood: Comparison with Peptidoglycan

Mattsson, Eva, Hartung, Thomas, Morath, Siegfried, Egesten, Arne

Lipoteichoic acid from Staphylococcus aureus was a potent inducer of procoagulant activity in isolated mononuclear cells but not in whole blood. In contrast, staphylococcal peptidoglycan showed equal...

Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids

Grangette, Corinne, Nutten, Sophie, Palumbo, Emmanuelle, Morath, Siegfried, Hermann, Corinna, Dewulf, Joelle, ...

Teichoic acids (TAs), and especially lipoteichoic acids (LTAs), are one of the main immunostimulatory components of pathogenic Gram-positive bacteria. Their contribution to the immunomodulatory...

β-lactam antibiotic-induced release of lipoteichoic acid from Staphylococcus aureus leads to activation of neutrophil granulocytes

Lotz, Sonja, Starke, Andrea, Ziemann, Christian, Morath, Siegfried, Hartung, Thomas, Solbach, Werner, ...

d-Alanyl Ester Depletion of Teichoic Acids in Lactobacillus plantarum Results in a Major Modification of Lipoteichoic Acid Composition and Cell Wall Perforations at the Septum Mediated by the Acm2 Autolysin

Palumbo, Emmanuelle, Deghorain, Marie, Cocconcelli, Pier Sandro, Kleerebezem, Michiel, Geyer, Armin, Hartung, Thomas, ...

The insertional inactivation of the dlt operon from Lactobacillus plantarum NCIMB8826 had a strong impact on lipoteichoic acid (LTA) composition, resulting in a major reduction in d-alanyl ester...

Structural Decomposition and Heterogeneity of Commercial Lipoteichoic Acid Preparations

Morath, Siegfried, Geyer, Armin, Spreitzer, Ingo, Hermann, Corinna, Hartung, Thomas

Fractionation of commercial preparations of lipoteichoic acids (LTA) by hydrophobic interaction chromatography (HIC) and nuclear magnetic resonance spectroscopy revealed very inhomogeneous...

Highly Purified Lipoteichoic Acid from Staphylococcus aureus Induces Procoagulant Activity and Tissue Factor Expression in Human Monocytes but Is a Weak Inducer in Whole Blood: Comparison with Peptidoglycan

Mattsson, Eva, Hartung, Thomas, Morath, Siegfried, Egesten, Arne

Lipoteichoic acid from Staphylococcus aureus was a potent inducer of procoagulant activity in isolated mononuclear cells but not in whole blood. In contrast, staphylococcal peptidoglycan showed equal...

Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids

Grangette, Corinne, Nutten, Sophie, Palumbo, Emmanuelle, Morath, Siegfried, Hermann, Corinna, Dewulf, Joelle, ...

Teichoic acids (TAs), and especially lipoteichoic acids (LTAs), are one of the main immunostimulatory components of pathogenic Gram-positive bacteria. Their contribution to the immunomodulatory...

d-Alanyl Ester Depletion of Teichoic Acids in Lactobacillus plantarum Results in a Major Modification of Lipoteichoic Acid Composition and Cell Wall Perforations at the Septum Mediated by the Acm2 Autolysin

Palumbo, Emmanuelle, Deghorain, Marie, Cocconcelli, Pier Sandro, Kleerebezem, Michiel, Geyer, Armin, Hartung, Thomas, ...

The insertional inactivation of the dlt operon from Lactobacillus plantarum NCIMB8826 had a strong impact on lipoteichoic acid (LTA) composition, resulting in a major reduction in d-alanyl ester...

β-lactam antibiotic-induced release of lipoteichoic acid from Staphylococcus aureus leads to activation of neutrophil granulocytes

Lotz, Sonja, Starke, Andrea, Ziemann, Christian, Morath, Siegfried, Hartung, Thomas, Solbach, Werner, ...

Synthetic Lipoteichoic Acid from Staphylococcus aureus Is a Potent Stimulus of Cytokine Release

Morath, Siegfried, Stadelmaier, Andreas, Geyer, Armin, Schmidt, Richard R., Hartung, Thomas

We recently purified lipoteichoic acid (LTA) from Staphylococcus aureus to more than 99% purity by a novel preparation method and deduced its structure with the first nuclear magnetic resonance (NMR)...

Structure–Function Relationship of Cytokine Induction by Lipoteichoic Acid fromStaphylococcus aureus

Morath, Siegfried, Geyer, Armin, Hartung, Thomas

Lipoteichoic acids (LTAs) have been proposed as putative Gram-positive immunostimulatory counterparts to Gram-negative lipopolysaccharides. However, LTA from Staphylococcus aureus, the clinically...