Toenjes, Martje, Schueler, Markus, Hammer, Stefanie, Pape, Utz J., Fischer, Jenny J., Felix Berger, Felix, ...
We present an integrative approach combining sophisticated techniques to construct cardiac gene regulatory networks based on correlated gene expression and optimized prediction of transcription...
Combinatorial effects of four histone modifications in transcription and differentiation (2008)
Fischer, Jenny J., Toedling, Joern, Krueger, Tammo, Schueler, Markus, Huber, Wolfgang, Sperling, Silke
Nucleosomes are involved in DNA compaction and transcriptional regulation. Yet it is unclear whether histone modification marks are primary or secondary to transcription and whether they interact to...
Characterization of TBX20 in human hearts and its regulation by TFAP2 (2008)
Hammer, Stefanie, Toenjes, Martje, Lange, Martin, Fischer, Jenny J., Dunkel, Ilona, Mebus, Siegrun, ...
The T-box family of transcription factors has been shown to have major impact on human development and disease. In animal studies Tbx20 is essential for the development of the atrioventricular...
Lange, Martin, Kaynak, Bogac, Forster, Ulrike B., Tönjes, Martje, Fischer, Jenny J., Grimm, Christina, ...
Chromatin remodeling and histone modifications facilitate access of transcription factors to DNA by promoting the unwinding and destabilization of histone–DNA interactions. We present DPF3, a new...
Lange, Martin, Kaynak, Bogac, Forster, Ulrike B., Tönjes, Martje, Fischer, Jenny J., Grimm, Christina, ...
Chromatin remodeling and histone modifications facilitate access of transcription factors to DNA by promoting the unwinding and destabilization of histone–DNA interactions. We present DPF3, a new...
Ringo – an R/Bioconductor package for analyzing ChIP-chip readouts (2007)
Toedling, Joern, Skylar, Oleg, Krueger, Tammo, Fischer, Jenny J, Sperling, Silke, Huber, Wolfgang
No abstract available.
Transcriptional regulation at a glance (2007)
Abstract Considering that 80 genomes have been sequenced, providing us with the static information of the genome, it is still a long way to reveal the relationship between complex genotypes and...
Genomic organization of transcriptomes in mammals: coregulation and cofunctionality (2007)
Purmann, Antje, Toedling, Joern, Schueler, Markus, Carninci, Piero, Lehrach, Hans, Hayashizaki, Yoshihide, ...
In studies of their transcriptional activity, genomes have shown a high order of organization. We assessed the question of how genomically neighboring genes are transcriptionally coupled across...
Transcriptional regulation at a glance (2007)
Considering that 80 genomes have been sequenced, providing us with the static information of the genome, it is still a long way to reveal the relationship between complex genotypes and phenotypes....
Ringo – an R/Bioconductor package for analyzing ChIP-chip readouts (2007)
Toedling, Joern, Skylar, Oleg, Krueger, Tammo, Fischer, Jenny J., Sperling, Silke, Huber, Wolfgang
From single cells to whole organisms (2006)
A report on the European Science Foundation Conference 'Functional Genomics and Disease', Oslo, Norway, 6-10 September 2005.
TaqMan probe array for quantitative detection of DNA targets (2006)
Liu, Heping, Wang, Hong, Shi, Zhiyang, Wang, Hua, Yang, Chaoyong, Sperling, Silke, ...
To date real-time quantitative PCR and gene expression microarrays are the methods of choice for quantification of nucleic acids. Herein, we described a unique fluorescence resonance energy...
A new statistical model to select target sequences bound by transcription factors (2006)
Pape, Utz J., Grossmann, Steffen, Hammer, Stefanie, Sperling, Silke, Vingron, Martin
Transcription factors (TFs) play a key role in gene regulation by binding to target sequences. In silico prediction of potential binding to a sequence is a main task in computational biology....
Chromosomal clustering of a human transcriptome reveals regulatory background (2005)
Vogel, Jan H, Von Heydebreck, Anja, Purmann, Antje, Sperling, Silke
Abstract Background There has been much evidence recently for a link between transcriptional regulation and chromosomal gene order, but the relationship between genomic organization, regulation and...
Sperling, Silke, Grimm, Christina H., Dunkel, Ilona, Mebus, Siegrun, Sperling, Hans-Peter, Ebner, Arno, ...
Recent reports have demonstrated that mice lacking the transcription factor Cited2 die in utero showing various cardiac malformations. We present for the first time functionally relevant mutations of...
A physiogenomic approach to study the regulation of blood pressure (2005)
Westhoff, Timm H., Scheid, Stefanie, Tölle, Markus, Kaynak, Bogac, Schmidt, Sven, Zidek, Walter, ...
Several vasoregulatory systems including the renin-angiotensin system, sympathetic vasoregulation, and cytokine release have been studied extensively. The aim of the present study was to establish a...
Chromosomal clustering of a human transcriptome reveals regulatory background (2005)
Vogel, Jan H., Von Heydebreck, Anja, Purmann, Antje, Sperling, Silke
Background There has been much evidence recently for a link between transcriptional regulation and chromosomal gene order, but the relationship between genomic organization, regulation and gene...
d-matrix – database exploration, visualization and analysis (2004)
Seelow, Dominik, Galli, Raffaello, Mebus, Siegrun, Sperling, Hans-Peter, Lehrach, Hans, Sperling, Silke
Abstract Background Motivated by a biomedical database set up by our group, we aimed to develop a generic database front-end with embedded knowledge discovery and analysis features. A major focus was...
d-matrix – database exploration, visualization and analysis (2004)
Seelow,Dominik, Galli,Raffaello, Mebus,Sigrun, Sperling,Hans-Peter, Lehrach,Hans, Sperling,Silke
Background Motivated by a biomedical database set up by our group, we aimed to develop a generic database front-end with embedded knowledge discovery and analysis features. A major focus was the...
Multiplexed real-time PCR using universal reporters (2004)
Rickert,Andreas M., Lehrach,Hans, Sperling,Silke
Real-time quantitative PCR is a sensitive and accurate method for gene expression studies (1). The detection chemistries of all real-time PCR procedures are based on one of two principles for...
Rickert,Andreas M., Borodina,Tatiana A., Kuhn,Eckehard J., Lehrach,Hans, Sperling,Silke
Single-nucleotide polymorphisms (SNPs) have proven to be powerful genetic markers for a variety of genetic applications, e.g., association studies leading to dissection of both monogenetic and...
Von Heydebreck,Anja, Sperling,Silke, Kaynak,Bogac, Lehrach,Hans, Vingron,Martin
In a genome-wide gene expression study, normal and congenitally malformed human hearts were examined using cDNA arrays. Statistical and bioinformatic methods were used in order to identify tissue-...
Heydebreck,Anja Von, Sperling,Silke, Kaynak,Bogac, Lehrach,Hans, Vingron,Martin
Zusammenfassung: In einer genomweiten Genexpressionsstudie wurden normale und fehlgebildete menschliche Herzen mittels cDNS-Arrays untersucht. Statistische und bioinformatische Methoden wurden...
Heydebreck, Anja Von, Sperling, Silke, Kaynak, Bogac, Lehrach, Hans, Vingron, Martin
Zusammenfassung: In einer genomweiten Genexpressionsstudie wurden normale und fehlgebildete menschliche Herzen mittels cDNS-Arrays untersucht. Statistische und bioinformatische Methoden wurden...
Von Heydebreck, Anja, Sperling, Silke, Kaynak, Bogac, Lehrach, Hans, Vingron, Martin
In a genome-wide gene expression study, normal and congenitally malformed human hearts were examined using cDNA arrays. Statistical and bioinformatic methods were used in order to identify tissue-...
Rickert, Andreas M., Borodina, Tatiana A., Kuhn, Eckehard J., Lehrach, Hans, Sperling, Silke
Single-nucleotide polymorphisms (SNPs) have proven to be powerful genetic markers for a variety of genetic applications, e.g., association studies leading to dissection of both monogenetic and...
Multiplexed real-time PCR using universal reporters (2004)
Rickert, Andreas M., Lehrach, Hans, Sperling, Silke
Real-time quantitative PCR is a sensitive and accurate method for gene expression studies (1). The detection chemistries of all real-time PCR procedures are based on one of two principles for...
d-matrix – database exploration, visualization and analysis (2004)
Seelow, Dominik, Galli, Raffaello, Mebus, Sigrun, Sperling, Hans-Peter, Lehrach, Hans, Sperling, Silke
Background Motivated by a biomedical database set up by our group, we aimed to develop a generic database front-end with embedded knowledge discovery and analysis features. A major focus was the...
A genome-wide transcriptional fingerprint of normal and malformed human hearts (2003)
Kaynak,Bogac, Von Heydebreck,Anja, Mebas,Siegrun, Seelow,Dominic, Vogel,Jan, Sperling,Hans-Peter, ...
Background— We present the first genome-wide cDNA array analysis of human congenitally malformed hearts and attempted to partially elucidate these complex phenotypes. Most congential heart defects,...
Genome-wide array analysis of normal and malformed human hearts (2003)
Kaynak,Bogac, Von Heydebreck,Anja, Mebus,Sigrun, Seelow,Dominik, Hennig,Steffen, Vogel,Jan, ...
Background We present the first genome-wide cDNA array analysis of human congenitally malformed hearts and attempted to partially elucidate these complex phenotypes. Most congential heart defects,...
A genome-wide transcriptional fingerprint of normal and malformed human hearts (2003)
Kaynak, Bogac, Von Heydebreck, Anja, Mebas, Siegrun, Seelow, Dominic, Vogel, Jan, Sperling, Hans-Peter, ...
Background— We present the first genome-wide cDNA array analysis of human congenitally malformed hearts and attempted to partially elucidate these complex phenotypes. Most congential heart defects,...
Genome-wide array analysis of normal and malformed human hearts (2003)
Kaynak, Bogac, Von Heydebreck, Anja, Mebus, Sigrun, Seelow, Dominik, Hennig, Steffen, Vogel, Jan, ...
Background We present the first genome-wide cDNA array analysis of human congenitally malformed hearts and attempted to partially elucidate these complex phenotypes. Most congential heart defects,...
Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene (2001)
Handschug, Katrin, Sperling, Silke, Yoon, Sung-Joo Kim, Hennig, Steffen, Clark, Adrian J.L., Huebner, Angela
The triple A syndrome (MIM 231550) is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia and alacrima. The frequent association with a variety of neurological...
d-matrix – database exploration, visualization and analysis
Seelow, Dominik, Galli, Raffaello, Mebus, Siegrun, Sperling, Hans-Peter, Lehrach, Hans, Sperling, Silke
Chromosomal clustering of a human transcriptome reveals regulatory background
Vogel, Jan H, Von Heydebreck, Anja, Purmann, Antje, Sperling, Silke
From single cells to whole organisms
A report on the European Science Foundation Conference 'Functional Genomics and Disease', Oslo, Norway, 6-10 September 2005.
d-matrix – database exploration, visualization and analysis
Seelow, Dominik, Galli, Raffaello, Mebus, Siegrun, Sperling, Hans-Peter, Lehrach, Hans, Sperling, Silke
Chromosomal clustering of a human transcriptome reveals regulatory background
Vogel, Jan H, Von Heydebreck, Anja, Purmann, Antje, Sperling, Silke
From single cells to whole organisms
A report on the European Science Foundation Conference 'Functional Genomics and Disease', Oslo, Norway, 6-10 September 2005.
Transcriptional regulation at a glance
Considering that 80 genomes have been sequenced, providing us with the static information of the genome, it is still a long way to reveal the relationship between complex genotypes and phenotypes....
Ringo – an R/Bioconductor package for analyzing ChIP-chip readouts
Toedling, Joern, Skylar, Oleg, Krueger, Tammo, Fischer, Jenny J, Sperling, Silke, Huber, Wolfgang
Lange, Martin, Kaynak, Bogac, Forster, Ulrike B., Tönjes, Martje, Fischer, Jenny J., Grimm, Christina, ...
Chromatin remodeling and histone modifications facilitate access of transcription factors to DNA by promoting the unwinding and destabilization of histone–DNA interactions. We present DPF3, a new...