Görtz, Birgit, Hayer, Silvia, Tuerck, Birgit, Zwerina, Jochen, Smolen, Josef S, Schett, Georg
Abstract Tumour necrosis factor (TNF) is considered to be a major factor in chronic synovial inflammation and is an inducer of mitogen-activated protein kinase (MAPK) signalling. In the present study...
JNK1 is not essential for TNF-mediated joint disease (2004)
Köller, Marcus, Hayer, Silvia, Redlich, Kurt, Ricci, Romeo, David, Jean-Pierre, Steiner, Günter, ...
Abstract Tumour necrosis factor (TNF) signalling molecules are considered as promising therapeutic targets of antirheumatic therapy. Among them, mitogen-activated protein kinases are thought to be of...
Osteoclasts are essential for TNF-α–mediated joint destruction
Redlich, Kurt, Hayer, Silvia, Ricci, Romeo, David, Jean-Pierre, Tohidast-Akrad, Makiyeh, Kollias, George, ...
The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the question of...
JNK1 is not essential for TNF-mediated joint disease
Köller, Marcus, Hayer, Silvia, Redlich, Kurt, Ricci, Romeo, David, Jean-Pierre, Steiner, Günter, ...
Tumour necrosis factor (TNF) signalling molecules are considered as promising therapeutic targets of antirheumatic therapy. Among them, mitogen-activated protein kinases are thought to be of central...
Görtz, Birgit, Hayer, Silvia, Tuerck, Birgit, Zwerina, Jochen, Smolen, Josef S, Schett, Georg
Tumour necrosis factor (TNF) is considered to be a major factor in chronic synovial inflammation and is an inducer of mitogen-activated protein kinase (MAPK) signalling. In the present study we...
Osteoclasts are essential for TNF-α–mediated joint destruction
Redlich, Kurt, Hayer, Silvia, Ricci, Romeo, David, Jean-Pierre, Tohidast-Akrad, Makiyeh, Kollias, George, ...
The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the question of...
JNK1 is not essential for TNF-mediated joint disease
Köller, Marcus, Hayer, Silvia, Redlich, Kurt, Ricci, Romeo, David, Jean-Pierre, Steiner, Günter, ...
Tumour necrosis factor (TNF) signalling molecules are considered as promising therapeutic targets of antirheumatic therapy. Among them, mitogen-activated protein kinases are thought to be of central...
Görtz, Birgit, Hayer, Silvia, Tuerck, Birgit, Zwerina, Jochen, Smolen, Josef S, Schett, Georg
Tumour necrosis factor (TNF) is considered to be a major factor in chronic synovial inflammation and is an inducer of mitogen-activated protein kinase (MAPK) signalling. In the present study we...
Redlich, Kurt, Görtz, Birgit, Hayer, Silvia, Zwerina, Jochen, Doerr, Nicholas, Kostenuik, Paul, ...
Local bone erosion and systemic bone loss are hallmarks of rheumatoid arthritis and cause progressive disability. Tumor necrosis factor (TNF) is a key mediator of arthritis and acts catabolically on...
CD44 is a determinant of inflammatory bone loss
Hayer, Silvia, Steiner, Günter, Görtz, Birgit, Reiter, Erika, Tohidast-Akrad, Makiyeh, Amling, Michael, ...
Chronic inflammation is a major trigger of local and systemic bone loss. Disintegration of cell–matrix interaction is a prerequisite for the invasion of inflammatory tissue into bone. CD44 is a...