Simon Clare

Expression of tetanus toxin Fragment C in tobacco chloroplasts

Tregoning, John S., Nixon, Peter, Kuroda, Hiroshi, Svab, Zora, Clare, Simon, Bowe, Frances, ...

Fragment C (TetC) is a non-toxic 47 kDa polypeptide fragment of tetanus toxin that can be used as a subunit vaccine against tetanus. Expression of TetC in Escherichia coli and yeast was dependent on...

Central Role for B Lymphocytes and CD4+ T Cells in Immunity to Infection by the Attaching and Effacing Pathogen Citrobacter rodentium

Simmons, Cameron P., Clare, Simon, Ghaem-Maghami, Marjan, Uren, Tania K., Rankin, Joanna, Huett, Allan, ...

Citrobacter rodentium, an attaching-effacing bacterial pathogen, establishes an acute infection of the murine colonic epithelium and induces a mild colitis in immunocompetent mice. This study...

Intracellular Adhesion Molecule 1 Plays a Key Role in Acquired Immunity to Salmonellosis

Clare, Simon, Goldin, Robert, Hale, Christine, Aspinall, Richard, Simmons, Cameron, Mastroeni, Pietro, ...

This study investigated the role of intracellular adhesion molecule 1 (ICAM-1) during Salmonella enterica serovar Typhimurium infection of mice. We show that ICAM-1 is expressed in and around...

Identification of a Novel Citrobacter rodentium Type III Secreted Protein, EspI, and Roles of This and Other Secreted Proteins in Infection

Mundy, Rosanna, Petrovska, Liljana, Smollett, Katherine, Simpson, Nandi, Wilson, Rebecca K., Yu, Jun, ...

Citrobacter rodentium is a member of a group of pathogens that colonize the lumen of the host gastrointestinal tract via attaching and effacing (A/E) lesion formation. C. rodentium, which causes...

Mucosal Vaccination against Serogroup B Meningococci: Induction of Bactericidal Antibodies and Cellular Immunity following Intranasal Immunization with NadA of Neisseria meningitidis and Mutants of Escherichia coli Heat-Labile Enterotoxin

Bowe, Frances, Lavelle, Ed C., McNeela, Edel A., Hale, Christine, Clare, Simon, Arico, Beatrice, ...

Conjugated polysaccharide vaccines protect against serogroup C meningococci. However, this approach cannot be applied to serogroup B, which is still a major cause of meningitis. We evaluated the...

Expression of tetanus toxin Fragment C in tobacco chloroplasts

Tregoning, John S., Nixon, Peter, Kuroda, Hiroshi, Svab, Zora, Clare, Simon, Bowe, Frances, ...

Fragment C (TetC) is a non-toxic 47 kDa polypeptide fragment of tetanus toxin that can be used as a subunit vaccine against tetanus. Expression of TetC in Escherichia coli and yeast was dependent on...

Central Role for B Lymphocytes and CD4+ T Cells in Immunity to Infection by the Attaching and Effacing Pathogen Citrobacter rodentium

Simmons, Cameron P., Clare, Simon, Ghaem-Maghami, Marjan, Uren, Tania K., Rankin, Joanna, Huett, Allan, ...

Citrobacter rodentium, an attaching-effacing bacterial pathogen, establishes an acute infection of the murine colonic epithelium and induces a mild colitis in immunocompetent mice. This study...

Intracellular Adhesion Molecule 1 Plays a Key Role in Acquired Immunity to Salmonellosis

Clare, Simon, Goldin, Robert, Hale, Christine, Aspinall, Richard, Simmons, Cameron, Mastroeni, Pietro, ...

This study investigated the role of intracellular adhesion molecule 1 (ICAM-1) during Salmonella enterica serovar Typhimurium infection of mice. We show that ICAM-1 is expressed in and around...

Identification of a Novel Citrobacter rodentium Type III Secreted Protein, EspI, and Roles of This and Other Secreted Proteins in Infection

Mundy, Rosanna, Petrovska, Liljana, Smollett, Katherine, Simpson, Nandi, Wilson, Rebecca K., Yu, Jun, ...

Citrobacter rodentium is a member of a group of pathogens that colonize the lumen of the host gastrointestinal tract via attaching and effacing (A/E) lesion formation. C. rodentium, which causes...

Mucosal Vaccination against Serogroup B Meningococci: Induction of Bactericidal Antibodies and Cellular Immunity following Intranasal Immunization with NadA of Neisseria meningitidis and Mutants of Escherichia coli Heat-Labile Enterotoxin

Bowe, Frances, Lavelle, Ed C., McNeela, Edel A., Hale, Christine, Clare, Simon, Arico, Beatrice, ...

Conjugated polysaccharide vaccines protect against serogroup C meningococci. However, this approach cannot be applied to serogroup B, which is still a major cause of meningitis. We evaluated the...

Candidate Live, Attenuated Salmonella enterica Serotype Typhimurium Vaccines with Reduced Fecal Shedding Are Immunogenic and Effective Oral Vaccines▿

Abd El Ghany, Moataz, Jansen, Angela, Clare, Simon, Hall, Lindsay, Pickard, Derek, Kingsley, Robert A., ...

Environmental shedding of genetically manipulated microorganisms is an issue impeding the development of new live vaccines. We have investigated the immunogenicity of a number of novel Salmonella...

Identification of a Novel Citrobacter rodentium Type III Secreted Protein, EspI, and Roles of This and Other Secreted Proteins in Infection

Mundy, Rosanna, Petrovska, Liljana, Smollett, Katherine, Simpson, Nandi, Wilson, Rebecca K., Yu, Jun, ...

Quorum sensing has an unexpected role in virulence in the model pathogen Citrobacter rodentium

Coulthurst, Sarah J, Clare, Simon, Evans, Terry J, Foulds, Ian J, Roberts, Kevin J, Welch, Martin, ...

The bacterial mouse pathogen Citrobacter rodentium causes attaching and effacing (AE) lesions in the same manner as pathogenic Escherichia coli, and is an important model for this mode of...