Directed evolution of PDZ variants to generate high-affinity detection reagents (2005)
Ferrer, Marc, Maiolo, Jim, Kratz, Patricia, Jackowski, Jessica L., Murphy, Dennis J., Delagrave, Simon, ...
High-throughput protease assays are used to identify new protease inhibitors which have the potential to become valuable therapeutic products. Antibodies are of great utility as affinity reagents to...
Directed evolution of PDZ variants to generate high-affinity detection reagents (2005)
Ferrer, Marc, Maiolo, Jim, Kratz, Patricia, Jackowski, Jessica L., Murphy, Dennis J., Delagrave, Simon, ...
High-throughput protease assays are used to identify new protease inhibitors which have the potential to become valuable therapeutic products. Antibodies are of great utility as affinity reagents to...
Delagrave, Simon, Murphy, Dennis J., Pruss, Jennifer L. Rittenhouse, Maffia, Anthony M., Marrs, Barry L., Bylina, Edward J., ...
Directed evolution has become an important enabling technology for the development of new enzymes in the chemical and pharmaceutical industries. Some of the most interesting substrates for these...
Delagrave, Simon, Catalan, John, Sweet, Charles, Drabik, Glenn, Henry, Andrew, Rees, Anthony, ...
HNK20 is a mouse monoclonal IgA that binds to the F glycoprotein of respiratory syncytial virus (RSV) and neutralizes the virus, both in vitro and in vivo. The single-chain antibody fragment (scFv)...
Combinatorial structure and function studies /--by Simon Delagrave. (1995)
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
Combinatorial structure and function studies (1995)
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
Combinatorial structure and function studies (1995)
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
Context dependence of phenotype prediction and diversity in combinatorial mutagenesis (1995)
Delagrave, Simon, Goldman, Ellen R., Youvan, Douglas C.
Two different combinatorial mutagenesis experiments on the light-harvesting II (LH2) protein of Rhodobacter capsulatus indicate that heuristic rules relating sequence directly to phenotype are...
Recursive ensemble mutagenesis (1993)
Delagrave, Simon, Goldman, Ellen R., Youvan, Douglas C.
We have developed a generally applicable experimental procedure to find functional proteins that are many mutational steps from wild type. Optimization algorithms, which are typically used to search...