Short title: Interpretation of meta-regression analyses (2007)
How should meta-regression analyses be undertaken and interpreted? Appropriate methods for meta-regression applied to a set of clinical trials, and the limitations and pitfalls in interpretation, are...
Abstract Multilevel models for meta-analysis (2007)
Simon G. Thompson, Rebecca M. Turner, David E. Warn
Meta-analysis can be considered a multilevel statistical problem, since information within studies is combined in the presence of potential heterogeneity between studies. Here a general multilevel...
Anne Whitehead, Rebecca M. Turner, Rumana Z. Omar, Simon G. Thompson
Meta-analyses using individual patient data are becoming increasingly common and have several advantages over meta-analyses of summary statistics. We explore the use of multilevel or hierarchical...
Murray, Elizabeth, McCambridge, Jim, Khadjesari, Zarnie, White, Ian R, Thompson, Simon G, Godfrey, Christine, ...
Abstract Background Excessive alcohol consumption is a significant public health problem throughout the world. Although there are a range of effective interventions to help heavy drinkers reduce...
Higgins, Julian P. T., Little, Julian, Ioannidis, John P. A., Bray, Molly S., Manolio, Teri A., Smeeth, Liam, ...
Screening for abdominal aortic aneurysm [2] (multiple letters) (2005)
Lamont, Peter M., Thompson, Simon G., Kim, L G., Scott, Alan P., Norman, Paul E., Jamrozik, Konrad, ...
Copyright © 2005 BMJ Publishing Group Ltd.
Screening for abdominal aortic aneurysm [2] (multiple letters) (2005)
Lamont, Peter M., Thompson, Simon G., Kim, L G., Scott, Alan P., Norman, Paul E., Jamrozik, Konrad, ...
Copyright © 2005 BMJ Publishing Group Ltd.
Flather, Marcus D., Shibata, Marcelo C., Coats, Andrew J.S., Van Veldhuisen, Dirk J., Parkhomenko, Aleksandr, Borbola, Joszef, ...
Aims Large randomized trials have shown that beta-blockers reduce mortality and hospital admissions in patients with heart failure. The effects of beta-blockers in elderly patients with a broad range...
Flather, Marcus D., Shibata, Marcelo C., Coats, Andrew J.S., Van Veldhuisen, Dirk J., Parkhomenko, Aleksandr, Borbola, Joszef, ...
Aims Large randomized trials have shown that beta-blockers reduce mortality and hospital admissions in patients with heart failure. The effects of beta-blockers in elderly patients with a broad range...
Higgins, Julian P. T., Thompson, Simon G., Deeks, Jonathan J., Altman, Douglas G.
Paper from the BMJ by Higgins J. P. T. et al Cochrane Reviews have recently started including the quantity I 2 to help readers assess the consistency of the results of studies in meta-analyses. What...
Chêne, Geneviève, Thompson, Simon G.
A major problem in reviewing the published results of different epidemiologic studies of the relation between a quantitative variable and the risk of disease is that the results are presented in many...
WHELTON, PAUL K., THOMPSON, SIMON G., BARNES, GRETA R., MIALL, WILLIAM E.
A total of 408 adult volunteers at Northwick Park Hospital, England, participated in an evaluation of the Vita-Stat automatic blood pressure (BP) recorder. During a five-day period in March 1981,...
Barber, Julie A, Thompson, Simon G
Objective To review critically the statistical methods used for health economic evaluations in randomised controlled trials where an estimate of cost is available for each patient in the study.
Measuring inconsistency in meta-analyses
Higgins, Julian P T, Thompson, Simon G, Deeks, Jonathan J, Altman, Douglas G
Cochrane Reviews have recently started including the quantity I2 to help readers assess the consistency of the results of studies in meta-analyses. What does this new quantity mean, and why is...
Clustering by health professional in individually randomised trials
Lee, Katherine J, Thompson, Simon G
Patient outcomes in many randomised trials depend crucially on the health professional delivering the intervention, but the resulting clustering is rarely considered in the analysis
Barber, Julie A, Thompson, Simon G
Objective To review critically the statistical methods used for health economic evaluations in randomised controlled trials where an estimate of cost is available for each patient in the study.
Measuring inconsistency in meta-analyses
Higgins, Julian P T, Thompson, Simon G, Deeks, Jonathan J, Altman, Douglas G
Cochrane Reviews have recently started including the quantity I2 to help readers assess the consistency of the results of studies in meta-analyses. What does this new quantity mean, and why is...
Clustering by health professional in individually randomised trials
Lee, Katherine J, Thompson, Simon G
Patient outcomes in many randomised trials depend crucially on the health professional delivering the intervention, but the resulting clustering is rarely considered in the analysis
Richard M. Nixon, Simon G. Thompson
Background: Overall assessments of cost-effectiveness are now commonplace in informing medical policy decision making. It is often important, however, also to investigate how cost-effectiveness...
Using multilevel models for assessing the variability of multinational resource use and cost data
Richard Grieve, Richard Nixon, Simon G. Thompson, Charles Normand
Multinational economic evaluations often calculate a single measure of cost-effectiveness using cost data pooled across several countries. To assess the validity of pooling international cost data...
Multilevel models for estimating incremental net benefits in multinational studies
Richard Grieve, Richard Nixon, Simon G. Thompson, John Cairns
Multilevel models (MLMs) have been recommended for estimating incremental net benefits (INBs) in multicentre cost-effectiveness analysis (CEA). However, these models have assumed that the INBs are...
Murray, Elizabeth, McCambridge, Jim, Khadjesari, Zarnie, White, Ian R, Thompson, Simon G, Godfrey, Christine, ...
Bias modelling in evidence synthesis
Rebecca M. Turner, David J. Spiegelhalter, Simon G. Thompson
Policy decisions often require synthesis of evidence from multiple sources, and the source studies typically vary in rigour and in relevance to the target question. We present simple methods of...
A re-evaluation of random-effects meta-analysis
Simon G. Thompson, David J. Spiegelhalter
Meta-analysis in the presence of unexplained heterogeneity is frequently undertaken by using a random-effects model, in which the effects underlying different studies are assumed to be drawn from a...
Accounting for uncertainty in health economic decision models by using model averaging
Christopher H. Jackson, Simon G. Thompson, Linda D. Sharples
Health economic decision models are subject to considerable uncertainty, much of which arises from choices between several plausible model structures, e.g. choices of covariates in a regression...
Bias modelling in evidence synthesis
Turner, Rebecca M, Spiegelhalter, David J, Smith, Gordon C S, Thompson, Simon G
Policy decisions often require synthesis of evidence from multiple sources, and the source studies typically vary in rigour and in relevance to the target question. We present simple methods of...
Accounting for uncertainty in health economic decision models by using model averaging
Jackson, Christopher H, Thompson, Simon G, Sharples, Linda D
Health economic decision models are subject to considerable uncertainty, much of which arises from choices between several plausible model structures, e.g. choices of covariates in a regression...
A re-evaluation of random-effects meta-analysis
Higgins, Julian P T, Thompson, Simon G, Spiegelhalter, David J
Meta-analysis in the presence of unexplained heterogeneity is frequently undertaken by using a random-effects model, in which the effects underlying different studies are assumed to be drawn from a...