Tiyawisutsri, Rachaneeporn, Holden, Matthew TG, Tumapa, Sarinna, Rengpipat, Sirirat, Clarke, Simon R, Foster, Simon J, ...
Abstract Background The bacterial biothreat agents Burkholderia mallei and Burkholderia pseudomallei are the cause of glanders and melioidosis, respectively. Genomic and epidemiological studies have...
Tiyawisutsri, Rachaneeporn, Holden, Matthew TG, Tumapa, Sarinna, Rengpipat, Sirirat, Clarke, Simon R, Foster, Simon J, ...
Abstract Background The bacterial biothreat agents Burkholderia mallei and Burkholderia pseudomallei are the cause of glanders and melioidosis, respectively. Genomic and epidemiological studies have...
Steen, Anton, Buist, Girbe, Horsburgh, Gavin J., Venema, Gerard, Kuipers, Oscar P., Foster, Simon J., ...
AcmA, the major autolysin of Lactococcus lactis MG1363 is a modular protein consisting of an N-terminal active site domain and a C-terminal peptidoglycan-binding domain. The active site domain is...
Clements, Mark O., Watson, Sean P., Poole, Robert K., Foster, Simon J.
A Staphylococcus aureus mutant (SPW3) apparently unable to survive long-term starvation was shown to have a transposon insertion within a gene homologous to ctaA of Bacillus subtilis which encodes a...
Clements, Mark O., Watson, Sean P., Foster, Simon J.
A Staphylococcus aureus mutant (SPW1) which is unable to survive long-term starvation was shown to have a transposon insertion within a gene homologous to the sodA family of manganese-dependent...
Atrih, Abdelmadjid, Bacher, Gerold, Allmaier, Günter, Williamson, Michael P., Foster, Simon J.
The composition and fine structure of the vegetative cell wall peptidoglycan from Bacillus subtilis were determined by analysis of its constituent muropeptides. The structures of 39 muropeptides,...
Horsburgh, Malcolm J., Ingham, Eileen, Foster, Simon J.
The Staphylococcus aureus genome encodes three ferric uptake repressor (Fur) homologues: Fur, PerR, and Zur. To determine the exact role of Fur in S. aureus, we inactivated the fur gene by allelic...
Peptidoglycan and Lipoteichoic Acid Modify Monocyte Phenotype in Human Whole Blood
Jørgensen, Pål F., Wang, Jacob E., Almlöf, Mia, Thiemermann, Christoph, Foster, Simon J., Solberg, Rigmor, ...
We examined the influence of the gram-positive cell wall products peptidoglycan (PepG) and lipoteichoic acid (LTA), compared to lipopolysaccharide (LPS), on the monocyte expression of receptors...
Horsburgh, Malcolm J., Clements, Mark O., Crossley, Howard, Ingham, Eileen, Foster, Simon J.
The Staphylococcus aureus genome encodes three ferric uptake regulator (Fur) homologues: Fur, PerR, and Zur. To determine the exact role of PerR, we inactivated the gene by allelic replacement using...
Wiltshire, Michael D., Foster, Simon J.
A model system mimicking Staphylococcus aureus bacteremia was developed by growth in serum under microaerobic conditions. Eight genes induced by growth in serum were identified, including an...
Paget, Mark S. B., Chamberlin, Leony, Atrih, Abdelmadjid, Foster, Simon J., Buttner, Mark J.
The sigE gene of Streptomyces coelicolor A3(2) encodes an RNA polymerase sigma factor belonging to the extracytoplasmic function (ECF) subfamily. Constructed sigE deletion and disruption mutants were...
Characterization of the Starvation-Survival Response of Staphylococcus aureus
Watson, Sean P., Clements, Mark O., Foster, Simon J.
The starvation-survival response of Staphylococcus aureus as a result of glucose, amino acid, phosphate, or multiple-nutrient limitation was investigated. Glucose and multiple-nutrient limitation...
Peptidoglycan Structural Dynamics during Germination of Bacillus subtilis 168 Endospores
Atrih, Abdelmadjid, Zöllner, Peter, Allmaier, Günter, Williamson, Michael P., Foster, Simon J.
Peptidoglycan structural dynamics during endospore germination of Bacillus subtilis 168 have been examined by muropeptide analysis. The first germination-associated peptidoglycan structural changes...
Chan, Pan F., Foster, Simon J., Ingham, Eileen, Clements, Mark O.
The role of ςB, an alternative sigma factor of Staphylococcus aureus, has been characterized in response to environmental stress, starvation-survival and recovery, and pathogenicity. ςB was mainly...
Chan, Pan F., Foster, Simon J.
The staphylococcal accessory regulator (encoded by sarA) is an important global regulator of virulence factor biosynthesis in Staphylococcus aureus. To further characterize its role in virulence...
Clarke, Simon R., Harris, Llinos G., Richards, R. Geoff, Foster, Simon J.
In order for Staphylococcus aureus to adhere to host extracellular matrix (ECM) substrates, it elicits a wide range of surface proteins. We have characterized a novel ∼1.1-MDa protein in S. aureus,...
Horsburgh, Malcolm J., Aish, Joanne L., White, Ian J., Shaw, Les, Lithgow, James K., Foster, Simon J.
The accessory sigma factor σB controls a general stress response that is thought to be important for Staphylococcus aureus survival and may contribute to virulence. The strain of choice for genetic...
Fukushima, Tatsuya, Yamamoto, Hiroki, Atrih, Abdelmadjid, Foster, Simon J., Sekiguchi, Junichi
The predicted amino acid sequence of Bacillus subtilis yfjS (renamed pdaA) exhibits high similarity to those of several polysaccharide deacetylases. β-Galactosidase fusion experiments and results of...
Horsburgh, Gavin J., Atrih, Abdelmadjid, Foster, Simon J.
The cortex peptidoglycan from endospores of Bacillus subtilis is responsible for the maintenance of dormancy. LytH (YunA) has been identified as a novel sporulation-specific component with a role in...
Role of a Cysteine Synthase in Staphylococcus aureus
Lithgow, James K., Hayhurst, Emma J., Cohen, Gerald, Aharonowitz, Yair, Foster, Simon J.
The gram-positive human pathogen Staphylococcus aureus is often isolated with media containing potassium tellurite, to which it has a higher level of resistance than Escherichia coli. The S. aureus...
Myhre, Anders E., Stuestøl, Jon Fredrik, Dahle, Maria K., Øverland, Gunhild, Thiemermann, Christoph, Foster, Simon J., ...
Several studies have implicated a role of peptidoglycan (PepG) as a pathogenicity factor in sepsis and organ injury, in part by initiating the release of inflammatory mediators. We wanted to...
Horsburgh, Malcolm J., Wiltshire, Michael D., Crossley, Howard, Ingham, Eileen, Foster, Simon J.
PheP, a putative amino acid permease in Staphylococcus aureus, contributes to starvation survival under glucose-limiting conditions and virulence. A pheP mutation led to poor growth after...
Huard, Carine, Miranda, Guy, Redko, Yulia, Wessner, Françoise, Foster, Simon J., Chapot-Chartier, Marie-Pierre
The peptidoglycan hydrolase (PGH) complement of Lactococcus lactis was identified by amino acid sequence similarity searching of the L. lactis IL-1403 complete genome sequence. Five PGHs that are not...
Shaw, Lindsey N., Golonka, Ewa, Szmyd, Grzegorz, Foster, Simon J., Travis, James, Potempa, Jan
The cytoplasmic protein SspC of Staphylococcus aureus, referred to as staphostatin B, is a very specific, tightly binding inhibitor of the secreted protease staphopain B (SspB). SspC is hypothesized...
Pourmand, Mohammad R., Clarke, Simon R., Schuman, Richard F., Mond, James J., Foster, Simon J.
A spectrum of in vivo-expressed Staphylococcus epidermidis antigens was identified by probing a bacteriophage lambda library of S. epidermidis genomic DNA with human serum from infected and...
Clements, Mark O., Watson, Sean P., Poole, Robert K., Foster, Simon J.
A Staphylococcus aureus mutant (SPW3) apparently unable to survive long-term starvation was shown to have a transposon insertion within a gene homologous to ctaA of Bacillus subtilis which encodes a...
Clements, Mark O., Watson, Sean P., Foster, Simon J.
A Staphylococcus aureus mutant (SPW1) which is unable to survive long-term starvation was shown to have a transposon insertion within a gene homologous to the sodA family of manganese-dependent...
Atrih, Abdelmadjid, Bacher, Gerold, Allmaier, Günter, Williamson, Michael P., Foster, Simon J.
The composition and fine structure of the vegetative cell wall peptidoglycan from Bacillus subtilis were determined by analysis of its constituent muropeptides. The structures of 39 muropeptides,...
Horsburgh, Malcolm J., Ingham, Eileen, Foster, Simon J.
The Staphylococcus aureus genome encodes three ferric uptake repressor (Fur) homologues: Fur, PerR, and Zur. To determine the exact role of Fur in S. aureus, we inactivated the fur gene by allelic...
Peptidoglycan and Lipoteichoic Acid Modify Monocyte Phenotype in Human Whole Blood
Jørgensen, Pål F., Wang, Jacob E., Almlöf, Mia, Thiemermann, Christoph, Foster, Simon J., Solberg, Rigmor, ...
We examined the influence of the gram-positive cell wall products peptidoglycan (PepG) and lipoteichoic acid (LTA), compared to lipopolysaccharide (LPS), on the monocyte expression of receptors...
Horsburgh, Malcolm J., Clements, Mark O., Crossley, Howard, Ingham, Eileen, Foster, Simon J.
The Staphylococcus aureus genome encodes three ferric uptake regulator (Fur) homologues: Fur, PerR, and Zur. To determine the exact role of PerR, we inactivated the gene by allelic replacement using...
Wiltshire, Michael D., Foster, Simon J.
A model system mimicking Staphylococcus aureus bacteremia was developed by growth in serum under microaerobic conditions. Eight genes induced by growth in serum were identified, including an...
Paget, Mark S. B., Chamberlin, Leony, Atrih, Abdelmadjid, Foster, Simon J., Buttner, Mark J.
The sigE gene of Streptomyces coelicolor A3(2) encodes an RNA polymerase sigma factor belonging to the extracytoplasmic function (ECF) subfamily. Constructed sigE deletion and disruption mutants were...
Characterization of the Starvation-Survival Response of Staphylococcus aureus
Watson, Sean P., Clements, Mark O., Foster, Simon J.
The starvation-survival response of Staphylococcus aureus as a result of glucose, amino acid, phosphate, or multiple-nutrient limitation was investigated. Glucose and multiple-nutrient limitation...
Peptidoglycan Structural Dynamics during Germination of Bacillus subtilis 168 Endospores
Atrih, Abdelmadjid, Zöllner, Peter, Allmaier, Günter, Williamson, Michael P., Foster, Simon J.
Peptidoglycan structural dynamics during endospore germination of Bacillus subtilis 168 have been examined by muropeptide analysis. The first germination-associated peptidoglycan structural changes...
Chan, Pan F., Foster, Simon J., Ingham, Eileen, Clements, Mark O.
The role of ςB, an alternative sigma factor of Staphylococcus aureus, has been characterized in response to environmental stress, starvation-survival and recovery, and pathogenicity. ςB was mainly...
Chan, Pan F., Foster, Simon J.
The staphylococcal accessory regulator (encoded by sarA) is an important global regulator of virulence factor biosynthesis in Staphylococcus aureus. To further characterize its role in virulence...
Clarke, Simon R., Harris, Llinos G., Richards, R. Geoff, Foster, Simon J.
In order for Staphylococcus aureus to adhere to host extracellular matrix (ECM) substrates, it elicits a wide range of surface proteins. We have characterized a novel ∼1.1-MDa protein in S. aureus,...
Horsburgh, Malcolm J., Aish, Joanne L., White, Ian J., Shaw, Les, Lithgow, James K., Foster, Simon J.
The accessory sigma factor σB controls a general stress response that is thought to be important for Staphylococcus aureus survival and may contribute to virulence. The strain of choice for genetic...
Fukushima, Tatsuya, Yamamoto, Hiroki, Atrih, Abdelmadjid, Foster, Simon J., Sekiguchi, Junichi
The predicted amino acid sequence of Bacillus subtilis yfjS (renamed pdaA) exhibits high similarity to those of several polysaccharide deacetylases. β-Galactosidase fusion experiments and results of...
Horsburgh, Gavin J., Atrih, Abdelmadjid, Foster, Simon J.
The cortex peptidoglycan from endospores of Bacillus subtilis is responsible for the maintenance of dormancy. LytH (YunA) has been identified as a novel sporulation-specific component with a role in...
Role of a Cysteine Synthase in Staphylococcus aureus
Lithgow, James K., Hayhurst, Emma J., Cohen, Gerald, Aharonowitz, Yair, Foster, Simon J.
The gram-positive human pathogen Staphylococcus aureus is often isolated with media containing potassium tellurite, to which it has a higher level of resistance than Escherichia coli. The S. aureus...
Myhre, Anders E., Stuestøl, Jon Fredrik, Dahle, Maria K., Øverland, Gunhild, Thiemermann, Christoph, Foster, Simon J., ...
Several studies have implicated a role of peptidoglycan (PepG) as a pathogenicity factor in sepsis and organ injury, in part by initiating the release of inflammatory mediators. We wanted to...
Horsburgh, Malcolm J., Wiltshire, Michael D., Crossley, Howard, Ingham, Eileen, Foster, Simon J.
PheP, a putative amino acid permease in Staphylococcus aureus, contributes to starvation survival under glucose-limiting conditions and virulence. A pheP mutation led to poor growth after...
Huard, Carine, Miranda, Guy, Redko, Yulia, Wessner, Françoise, Foster, Simon J., Chapot-Chartier, Marie-Pierre
The peptidoglycan hydrolase (PGH) complement of Lactococcus lactis was identified by amino acid sequence similarity searching of the L. lactis IL-1403 complete genome sequence. Five PGHs that are not...
Shaw, Lindsey N., Golonka, Ewa, Szmyd, Grzegorz, Foster, Simon J., Travis, James, Potempa, Jan
The cytoplasmic protein SspC of Staphylococcus aureus, referred to as staphostatin B, is a very specific, tightly binding inhibitor of the secreted protease staphopain B (SspB). SspC is hypothesized...
Pourmand, Mohammad R., Clarke, Simon R., Schuman, Richard F., Mond, James J., Foster, Simon J.
A spectrum of in vivo-expressed Staphylococcus epidermidis antigens was identified by probing a bacteriophage lambda library of S. epidermidis genomic DNA with human serum from infected and...
Shaw, Lindsey N., Aish, Joanne, Davenport, Jessica E., Brown, Melanie C., Lithgow, James K., Simmonite, Kay, ...
The commonly used Staphylococcus aureus laboratory strain 8325-4 bears a naturally occurring 11-bp deletion in the σB-regulating phosphatase rsbU. We have previously published a report (M. J....
Tiyawisutsri, Rachaneeporn, Holden, Matthew TG, Tumapa, Sarinna, Rengpipat, Sirirat, Clarke, Simon R, Foster, Simon J, ...
Pignocchi, Cristina, Kiddle, Guy, Hernández, Iker, Foster, Simon J., Asensi, Amparo, Taybi, Tahar, ...
The role of the redox state of the apoplast in hormone responses, signaling cascades, and gene expression was studied in transgenic tobacco (Nicotiana tabacum) plants with modified cell...
Cosgrove, Kate, Coutts, Graham, Jonsson, Ing-Marie, Tarkowski, Andrej, Kokai-Kun, John F., Mond, James J., ...
Oxidative-stress resistance in Staphylococcus aureus is linked to metal ion homeostasis via several interacting regulators. In particular, PerR controls the expression of a regulon of genes, many of...
Murch, Oliver, Collin, Marika, Sepodes, Bruno, Foster, Simon J, Mota-Filipe, Helder, Thiemermann, Christoph
Lysophosphatidylcholine (LPC) modulates the inflammatory response and reduces mortality in animal models of sepsis. Here, we investigate the effects of LPC from synthetic (sLPC) and natural, soy bean...
Masumoto, Junya, Yang, Kangkang, Varambally, Sooryanarayana, Hasegawa, Mizuho, Tomlins, Scott A., Qiu, Su, ...
Nod1 is a member of family of intracellular proteins that mediate host recognition of bacterial peptidoglycan. To characterize immune responses mediated by Nod1, synthetic ligand compounds possessing...
Characterization of IsaA and SceD, Two Putative Lytic Transglycosylases of Staphylococcus aureus▿
Stapleton, Melanie R., Horsburgh, Malcolm J., Hayhurst, Emma J., Wright, Lynda, Jonsson, Ing-Marie, Tarkowski, Andrej, ...
Bacterial cell wall peptidoglycan is a dynamic structure requiring hydrolysis to allow cell wall growth and division. Staphylococcus aureus has many known and putative peptidoglycan hydrolases,...
Kengatharan, Ken M., De Kimpe, Sjef, Robson, Caroline, Foster, Simon J., Thiemermann, Christoph
The incidence of septic shock caused by gram-positive bacteria has risen markedly in the last few years. It is largely unclear how gram-positive bacteria (which do not contain endotoxin) cause shock...
IsdA Protects Staphylococcus aureus against the Bactericidal Protease Activity of Apolactoferrin▿
Clarke, Simon R., Foster, Simon J.
An important facet of the Staphylococcus aureus host-pathogen interaction is the ability of the invading bacterium to evade host innate defenses, particularly the cocktail of host antimicrobial...