Simon M. Cutting

Emerging Applications of Bacterial Spores in Nanobiotechnology (2003)

Ricca, Ezio, Cutting, Simon M

Abstract Bacterial spores are robust and dormant life forms with formidable resistance properties, in part, attributable to the multiple layers of protein that encase the spore in a protective and...

Long-term consequences of the Vietnam War : ethics, law, policy

Searcy, Chuck, Cutting, Simon M.

Report produced in connection with the Environmental Conference on Cambodia, Laos and Vietnam. The purpose of the conference was to review the long-term consequences of the Vietnam War, which also...

Characterization of Bacillus Species Used for Oral Bacteriotherapy and Bacterioprophylaxis of Gastrointestinal Disorders

Hoa, Ngo Thi, Baccigalupi, Loredana, Huxham, Ashley, Smertenko, Andrei, Van, Pham Hung, Ammendola, Sergio, ...

Bacillus subtilis spores are being used for oral bacteriotherapy and bacterioprophylaxis of gastrointestinal disorders in both humans and animals. Since B. subtilis is an aerobic saprophyte, how...

Fate and Dissemination of Bacillus subtilis Spores in a Murine Model

Hoa, Tran Thu, Duc, Le Hong, Isticato, Rachele, Baccigalupi, Loredana, Ricca, Ezio, Van, Pham Hung, ...

Bacterial spores are being consumed as probiotics, although little is known about their efficacy or mode of action. As a first step in characterizing spore probiotics, we have studied the persistence...

Membrane Topology of the Bacillus subtilis Pro-ςK Processing Complex

Green, David H., Cutting, Simon M.

Activation of the final sporulation-specific transcription factor, ςK, is regulated by a signal emanating from the forespore which interacts with the pro-ςK processing complex, comprising SpoIVFA,...

The PDZ Domain of the SpoIVB Serine Peptidase Facilitates Multiple Functions

Hoa, Ngo T., Brannigan, James A., Cutting, Simon M.

During spore formation in Bacillus subtilis, the SpoIVB protein is a critical component of the ςK regulatory checkpoint. SpoIVB has been shown to be a serine peptidase that is synthesized in the...

Characterization of Two Bacillus Probiotics

Green, David H., Wakeley, Phil R., Page, Anthony, Barnes, Andrew, Baccigalupi, Loredana, Ricca, Ezio, ...

Bacillus subtilis is currently used as an oral probiotic. We examined two commercial B. subtilis probiotic preparations, Enterogermina and Biosubtyl. Surprisingly, physiological and genetic...

Bacillus Probiotics: Spore Germination in the Gastrointestinal Tract

Casula, Gabriella, Cutting, Simon M.

Spores of Bacillus species are being used commercially as probiotics and competitive exclusion agents. Unlike the more commonly used Lactobacillus-type probiotics, spores are dormant life forms. To...

The Bacillus subtilis Signaling Protein SpoIVB Defines a New Family of Serine Peptidases

Hoa, Ngo T., Brannigan, James A., Cutting, Simon M.

The protein SpoIVB plays a key role in signaling in the ςK checkpoint of Bacillus subtilis. This regulatory mechanism coordinates late gene expression during development in this organism and we have...

Bacterial Spores as Vaccine Vehicles

Duc, Le H., Hong, Huynh A., Fairweather, Neil, Ricca, Ezio, Cutting, Simon M.

For the first time, bacterial spores have been evaluated as vaccine vehicles. Bacillus subtilis spores displaying the tetanus toxin fragment C (TTFC) antigen were used for oral and intranasal...

Emerging Applications of Bacterial Spores in Nanobiotechnology

Ricca, Ezio, Cutting, Simon M

Bacterial spores are robust and dormant life forms with formidable resistance properties, in part, attributable to the multiple layers of protein that encase the spore in a protective and flexible...

Characterization of Bacillus Probiotics Available for Human Use

Duc, Le H., Hong, Huynh A., Barbosa, Teresa M., Henriques, Adriano O., Cutting, Simon M.

Bacillus species (Bacillus cereus, Bacillus clausii, Bacillus pumilus) carried in five commercial probiotic products consisting of bacterial spores were characterized for potential attributes...

The Intestinal Life Cycle of Bacillus subtilis and Close Relatives†

Tam, Nguyen K. M., Uyen, Nguyen Q., Hong, Huynh A., Duc, Le H., Hoa, Tran T., Serra, Claudia R., ...

Bacillus subtilis is considered a soil organism for which endospore formation provides a means to ensure long-term survival in the environment. We have addressed here the question of what happens to...

Characterization of Bacillus Species Used for Oral Bacteriotherapy and Bacterioprophylaxis of Gastrointestinal Disorders

Hoa, Ngo Thi, Baccigalupi, Loredana, Huxham, Ashley, Smertenko, Andrei, Van, Pham Hung, Ammendola, Sergio, ...

Bacillus subtilis spores are being used for oral bacteriotherapy and bacterioprophylaxis of gastrointestinal disorders in both humans and animals. Since B. subtilis is an aerobic saprophyte, how...

Fate and Dissemination of Bacillus subtilis Spores in a Murine Model

Hoa, Tran Thu, Duc, Le Hong, Isticato, Rachele, Baccigalupi, Loredana, Ricca, Ezio, Van, Pham Hung, ...

Bacterial spores are being consumed as probiotics, although little is known about their efficacy or mode of action. As a first step in characterizing spore probiotics, we have studied the persistence...

Membrane Topology of the Bacillus subtilis Pro-ςK Processing Complex

Green, David H., Cutting, Simon M.

Activation of the final sporulation-specific transcription factor, ςK, is regulated by a signal emanating from the forespore which interacts with the pro-ςK processing complex, comprising SpoIVFA,...

The PDZ Domain of the SpoIVB Serine Peptidase Facilitates Multiple Functions

Hoa, Ngo T., Brannigan, James A., Cutting, Simon M.

During spore formation in Bacillus subtilis, the SpoIVB protein is a critical component of the ςK regulatory checkpoint. SpoIVB has been shown to be a serine peptidase that is synthesized in the...

Characterization of Two Bacillus Probiotics

Green, David H., Wakeley, Phil R., Page, Anthony, Barnes, Andrew, Baccigalupi, Loredana, Ricca, Ezio, ...

Bacillus subtilis is currently used as an oral probiotic. We examined two commercial B. subtilis probiotic preparations, Enterogermina and Biosubtyl. Surprisingly, physiological and genetic...

Bacillus Probiotics: Spore Germination in the Gastrointestinal Tract

Casula, Gabriella, Cutting, Simon M.

Spores of Bacillus species are being used commercially as probiotics and competitive exclusion agents. Unlike the more commonly used Lactobacillus-type probiotics, spores are dormant life forms. To...

The Bacillus subtilis Signaling Protein SpoIVB Defines a New Family of Serine Peptidases

Hoa, Ngo T., Brannigan, James A., Cutting, Simon M.

The protein SpoIVB plays a key role in signaling in the ςK checkpoint of Bacillus subtilis. This regulatory mechanism coordinates late gene expression during development in this organism and we have...

Bacterial Spores as Vaccine Vehicles

Duc, Le H., Hong, Huynh A., Fairweather, Neil, Ricca, Ezio, Cutting, Simon M.

For the first time, bacterial spores have been evaluated as vaccine vehicles. Bacillus subtilis spores displaying the tetanus toxin fragment C (TTFC) antigen were used for oral and intranasal...

Emerging Applications of Bacterial Spores in Nanobiotechnology

Ricca, Ezio, Cutting, Simon M

Bacterial spores are robust and dormant life forms with formidable resistance properties, in part, attributable to the multiple layers of protein that encase the spore in a protective and flexible...

Characterization of Bacillus Probiotics Available for Human Use

Duc, Le H., Hong, Huynh A., Barbosa, Teresa M., Henriques, Adriano O., Cutting, Simon M.

Bacillus species (Bacillus cereus, Bacillus clausii, Bacillus pumilus) carried in five commercial probiotic products consisting of bacterial spores were characterized for potential attributes...

The Intestinal Life Cycle of Bacillus subtilis and Close Relatives†

Tam, Nguyen K. M., Uyen, Nguyen Q., Hong, Huynh A., Duc, Le H., Hoa, Tran T., Serra, Claudia R., ...

Bacillus subtilis is considered a soil organism for which endospore formation provides a means to ensure long-term survival in the environment. We have addressed here the question of what happens to...

Recombinant Bacillus subtilis Expressing the Clostridium perfringens Alpha Toxoid Is a Candidate Orally Delivered Vaccine against Necrotic Enteritis▿

Hoang, Tran H., Hong, Huynh A., Clark, Graeme C., Titball, Richard W., Cutting, Simon M.

Recombinant Bacillus subtilis endospores have been used to vaccinate against tetanus and anthrax. In this work, we have developed spores that could be used to vaccinate against Clostridium...

Searching for Protein-Protein Interactions within the Bacillus subtilis Spore Coat▿

Krajčíková, Daniela, Lukáčová, Magda, Müllerová, Denisa, Cutting, Simon M., Barák, Imrich

The capability of endospores of Bacillus subtilis to withstand extreme environmental conditions is secured by several attributes. One of them, the protein shell that encases the spore and is known as...