Simona Urbani

Virus-Specific CD8+ Lymphocytes Share the Same Effector-Memory Phenotype but Exhibit Functional Differences in Acute Hepatitis B and C

Urbani, Simona, Boni, Carolina, Missale, Gabriele, Elia, Gianfranco, Cavallo, Cristina, Massari, Marco, ...

Hepatitis B and hepatitis C viruses (HBV and HCV) are both noncytopathic and can cause acute and chronic infections of the liver. Although they share tropism for the same organ, development of...

Virus-Specific CD8+ Lymphocytes Share the Same Effector-Memory Phenotype but Exhibit Functional Differences in Acute Hepatitis B and C

Urbani, Simona, Boni, Carolina, Missale, Gabriele, Elia, Gianfranco, Cavallo, Cristina, Massari, Marco, ...

Hepatitis B and hepatitis C viruses (HBV and HCV) are both noncytopathic and can cause acute and chronic infections of the liver. Although they share tropism for the same organ, development of...

PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion▿

Urbani, Simona, Amadei, Barbara, Tola, Daniela, Massari, Marco, Schivazappa, Simona, Missale, Gabriele, ...

Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in exhausted CD8 cells. Therefore,...

Heterologous T cell immunity in severe hepatitis C virus infection

Urbani, Simona, Amadei, Barbara, Fisicaro, Paola, Pilli, Massimo, Missale, Gabriele, Bertoletti, Antonio, ...

Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection has been shown in mice to...