Shanely, RA, Coombes, JS, Zergeroglu, AM, Webb, AI, Powers, SK
Study objectives: Mechanical ventilation (MV) is a life-support measure for patients who cannot maintain adequate alveolar ventilation. Following prolonged MV, difficulty in weaning patients from the...
Mechanical ventilation results in progressive contractile dysfunction in the diaphragm (2002)
Powers, SK, Shanely, RA, Coombes, JS, Koesterer, TJ, McKenzie, M, Van Gammeren, D, ...
These experiments tested the hypothesis that a relatively short duration of controlled mechanical ventilation (MV) will impair diaphragmatic maximal specific force generation (specific P-o) and that...
Effects of vitamin E deficiency on fatigue and muscle contractile properties (2002)
Coombes, JS, Rowell, B, Dodd, SL, Demirel, HA, Naito, H, Shanely, RA, ...
Radical-mediated oxidative damage of skeletal muscle membranes has been implicated in the fatigue process. Vitamin E (VE) is a major chain breaking antioxidant that has been shown to reduce...
Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat (2001)
Demirel, HA, Powers, SK, Zergeroglu, MA, Shanely, RA, Hamilton, K, Coombes, J, ...
These experiments examined the independent effects of short-term exercise and heat stress on myocardial responses during in vivo ischemia-reperfusion (I/R). Female Sprague-Dawley rats (4 mo old) were...
Effects of vitamin E and alpha-lipoic acid on skeletal muscle contractile properties (2001)
Coombes, JS, Powers, SK, Rowell, B, Hamilton, KL, Dodd, SL, Shanely, RA, ...
Initial experiments were conducted using an in situ rat tibialis anterior (TA) muscle preparation to assess the influence of dietary antioxidants on muscle contractile properties. Adult...
Coombes, JS, Powers, SK, Demirel, HA, Hamilton, KL, Jessup, J, Vincent, HK, ...
Vitamin E content of cardiac tissue has been proposed to play a major role in the damage caused by myocardial ischemia-reperfusion (I-R). Previous studies using in vitro models have examined vitamin...