Glutamate transporter blockade affects $Ca^{2+}$ responses in astrocytes (2008)
Brief pretreatment of astrocytes in culture with glutamate (500 \mu M for 20 min), was earlier shown to significantly enhance the $Ca^{2+}$ responses to a depolarizing pulse. It is known that...
Glutamate transporter blockade affects $Ca^{2+}$ responses in astrocytes (2008)
Brief pretreatment of astrocytes in culture with glutamate (500 \mu M for 20 min), was earlier shown to significantly enhance the $Ca^{2+}$ responses to a depolarizing pulse. It is known that...
Time-Dependent Molecular Memory in Single Voltage-Gated Sodium Channel (2007)
Excitability in neurons is associated with firing of action potentials and requires the opening of voltage-gated sodium channels with membrane depolarization. Sustained membrane depolarization, as...
Time-Dependent Molecular Memory in Single Voltage-Gated Sodium Channel (2007)
Excitability in neurons is associated with firing of action potentials and requires the opening of voltage-gated sodium channels with membrane depolarization. Sustained membrane depolarization, as...
Glial cells in the brain are capable of responding to hormonal signals. The ovarian steroid hormone 17\beta-estradiol, in addition to its actions on neurons, can directly affect glial cells. Estrogen...
Glial cells in the brain are capable of responding to hormonal signals. The ovarian steroid hormone 17\beta-estradiol, in addition to its actions on neurons, can directly affect glial cells. Estrogen...
Fast Pseudo-Periodic Oscillation in the Rat Brain Voltage-gated Sodium Channel α Subunit (2005)
In the work reported here, we have investigated the changes in the activation and fast inactivation properties of the rat brain voltage-gated sodium channel $(rNa_v 1.2a)$ $\alpha$ subunit, expressed...
Inhibition of human TREK-1 channels by caffeine and theophylline (2005)
Caffeine (1,3,7-trimethylxanthine) and theophylline(1,3-dimethylxanthine) are used for therapeutic purposes and can cause life-threatening convulsive seizures due to systemic toxicity. The mechanisms...
Inhibition of human TREK-1 channels by caffeine and theophylline (2005)
Caffeine (1,3,7-trimethylxanthine) and theophylline(1,3-dimethylxanthine) are used for therapeutic purposes and can cause life-threatening convulsive seizures due to systemic toxicity. The mechanisms...
Fast Pseudo-Periodic Oscillation in the Rat Brain Voltage-gated Sodium Channel α Subunit (2005)
In the work reported here, we have investigated the changes in the activation and fast inactivation properties of the rat brain voltage-gated sodium channel $(rNa_v 1.2a)$ $\alpha$ subunit, expressed...
The ovarian steroid hormone estradiol, in addition to its function in the maintenance and regulation of reproductive capacity, can alter neuronal excitability. Estradiol is proconvulsant, increases...
Trichloroethanol enhances the activity ofrecombinant human TREK-1 and TRAAK channels (2004)
Human TREK-1 and TRAAK (hTREK-1 and hTRAAK) are the recently cloned tandem pore-domain potassium channels that are highly expressed in the central nervous system (CNS). The roles of2P domain $K^+$...
Padmashri, R, Chakrabarti, KS, Sahal, D, Mahalakshmi, R, Sarma, SP, Sikdar, SK
The endogenous pentapeptide QYNAD (Gln- Tyr-Asn-Ala-Asp) is present in human cerebrospinal fluid (CSF), and its concentration is increased in demyelinating diseases. QYNAD was synthesized and its...
The ovarian steroid hormone estradiol, in addition to its function in the maintenance and regulation of reproductive capacity, can alter neuronal excitability. Estradiol is proconvulsant, increases...
Padmashri, R, Chakrabarti, KS, Sahal, D, Mahalakshmi, R, Sarma, SP, Sikdar, SK
The endogenous pentapeptide QYNAD (Gln- Tyr-Asn-Ala-Asp) is present in human cerebrospinal fluid (CSF), and its concentration is increased in demyelinating diseases. QYNAD was synthesized and its...
Trichloroethanol enhances the activity ofrecombinant human TREK-1 and TRAAK channels (2004)
Human TREK-1 and TRAAK (hTREK-1 and hTRAAK) are the recently cloned tandem pore-domain potassium channels that are highly expressed in the central nervous system (CNS). The roles of2P domain $K^+$...
Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail (2003)
Sudarslal, S, Majumdar, Sriparna, Ramasamy, P, Dhawan, Ritu, Pal, Prajna P, Ramaswami, Mani, ...
A 26 residue peptide (Am 2766) with the sequence CKQAGESCDIFSQNCCVG-TCAFICIE-NH2 has been isolated and purified from the venom of the molluscivorous snail, Conus amadis, collected off the...
Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail (2003)
Sudarslal, S, Majumdar, Sriparna, Ramasamy, P, Dhawan, Ritu, Pal, Prajna P, Ramaswami, Mani, ...
A 26 residue peptide (Am 2766) with the sequence CKQAGESCDIFSQNCCVG-TCAFICIE-NH2 has been isolated and purified from the venom of the molluscivorous snail, Conus amadis, collected off the...
Ramesh, J, Ghosh, JK, Swaminathan, CP, Ramasamy, P, Surolia, A, Sikdar, SK, ...
The interaction of zwitterionic lipid DMPC and DPPC with cyclic hexapeptide, cyclo $(d-Ala-l-Pro-l-Ala)_2$ was studied using circular dichroism (CD) and differential scanning calorimetry (DSC)....
Ramesh, J, Ghosh, JK, Swaminathan, CP, Ramasamy, P, Surolia, A, Sikdar, SK, ...
The interaction of zwitterionic lipid DMPC and DPPC with cyclic hexapeptide, cyclo $(d-Ala-l-Pro-l-Ala)_2$ was studied using circular dichroism (CD) and differential scanning calorimetry (DSC)....
Ghatpande, AS, Rao, S, Sikdar, SK
Tetrapentylammonium (TPeA) block of rat brain type IIA sodium channel alpha subunit was studied using whole cell patch clamp. Results indicate that TPeA blocks the inactivating brain sodium channel...
Ghatpande, AS, Rao, S, Sikdar, SK
Tetrapentylammonium (TPeA) block of rat brain type IIA sodium channel alpha subunit was studied using whole cell patch clamp. Results indicate that TPeA blocks the inactivating brain sodium channel...
The non-inactivating $K^+$ currents in $\alpha T3-1$, a gonadotroph cell line, were recorded in the presence of low intracellular free calcium concentration. The activation kinetics of the whole-cell...
Modification of alpha subunit of RIIA sodium channels by aconitine (2000)
The effect of aconitine (AC), an alkaloid toxin, on the electrophysiological properties of the rat brain type IIA alpha subunit expressed heterologously in the Chinese Hamster Ovarian (CHO) cell line...
Modification of alpha subunit of RIIA sodium channels by aconitine (2000)
The effect of aconitine (AC), an alkaloid toxin, on the electrophysiological properties of the rat brain type IIA alpha subunit expressed heterologously in the Chinese Hamster Ovarian (CHO) cell line...
The non-inactivating $K^+$ currents in $\alpha T3-1$, a gonadotroph cell line, were recorded in the presence of low intracellular free calcium concentration. The activation kinetics of the whole-cell...
The voltage-dependent kinetics of veratridine-modified RIIA Na+ channel alpha subunit expressed heterologously in CHO cells were studied using the whole-cell patch-clamp technique. The activation and...
Temperature-dependent conformational changes in a voltage-gated potassium channel (1999)
Temperature was used as a biophysical tool to investigate the energy changes associated with conformational change during the gating of a non-inactivating voltage-gated K+ channel present in the...
The voltage-dependent kinetics of veratridine-modified RIIA Na+ channel alpha subunit expressed heterologously in CHO cells were studied using the whole-cell patch-clamp technique. The activation and...
Temperature-dependent conformational changes in a voltage-gated potassium channel (1999)
Temperature was used as a biophysical tool to investigate the energy changes associated with conformational change during the gating of a non-inactivating voltage-gated K+ channel present in the...
Bilayers containing calcium ionophore A23187 form channels (1992)
Balasubramanian, SV, Sikdar, SK, Easwaran, KRK
For the first time, based on bilayer membrane conductance experiments, it has been shown that A23187, a carboxylic calcium ionophore, incorporated in lipid bilayers gives single channel currents...
Bilayers containing calcium ionophore A23187 form channels (1992)
Balasubramanian, SV, Sikdar, SK, Easwaran, KRK
For the first time, based on bilayer membrane conductance experiments, it has been shown that A23187, a carboxylic calcium ionophore, incorporated in lipid bilayers gives single channel currents...