Sofia Aronova

Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p (2006)

Reinke, Aaron, Chen, Jenny C-Y, Aronova, Sofia, Powers, Ted

The target of rapamycin (TOR) kinase is an important regulator of growth in eukaryotic cells. In budding yeast, Tor1p and Tor2p function as part of two distinct protein complexes, TORC1 and TORC2,...

Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1p center dot Rtg3p-dependent target genes (2004)

Dilova, Ivanka, Aronova, Sofia, Chen, Jenny C-Y, Powers, Ted

The heterodimeric bZip/HLH transcription factors Rtg1p and Rtg3p regulate the expression of a concise set of metabolic genes (termed RTG target genes) required for de novo biosynthesis of glutamate...

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae (2004)

Reinke, Aaron, Anderson, Scott, McCaffery, J Michael, Yates, John, Aronova, Sofia, Chu, Stephanie, ...

The Tor1p and Tor2p kinases, targets of the therapeutically important antibiotic rapamycin, function as components of two distinct protein complexes in yeast, termed TOR complex 1 (TORC1) and TORC2....

Probing the Membrane Environment of the TOR Kinases Reveals Functional Interactions between TORC1, Actin, and Membrane Trafficking in Saccharomyces cerevisiae

Aronova, Sofia, Wedaman, Karen, Anderson, Scott, Yates, John, Powers, Ted

The TOR kinases are regulators of growth in eukaryotic cells that assemble into two distinct protein complexes, TORC1 and TORC2, where TORC1 is inhibited by the antibiotic rapamycin. Present models...