RhoA-GDP regulates RhoB protein stability. Potential involvement of RhoGDIalpha. (2008)
Ho, Giang, Merajver, Sofia D, Lapière, Charles, Nusgens, Betty, Deroanne, Christophe
RhoA plays a significant role in actin stress fibers formation. However, silencing RhoA alone or RhoA and RhoC did not completely suppress the stress fibers suggesting a residual "Rho-like" activity....
Marck, Eric A., Golen, Kenneth L., Vermeulen, Peter B., Eynden, Gert G., Laere, Steven J., Auwera, Ilse, ...
Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC). The IBC phenotype is characterized by an infiltrative growth pattern, increased...
Zhang, Yanhong, Pan, Quintin, Zhong, Hui, Merajver, Sofia D, Kleer, Celina G
Abstract Introduction CCN6/WISP3 belongs to the CCN (Cyr61, CTGF, Nov) family of genes that contains a conserved insulin-like growth factor (IGF) binding protein motif. CCN6 is a secreted protein...
Sabel, Michael S., Merajver, Sofia D., Kleer, Celina G., Griffith, Kent A., Gallagher, Gary, Wu, Zhi-Fen, ...
Background. There is a need for reliable predictors of breast cancer aggressiveness that will further refine the staging classification and help guide the implementation of novel therapies. We have...
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1 (2005)
Lin, Min, DiVito, Melinda M, Merajver, Sofia D, Boyanapalli, Madanamohan, Van Golen, Kenneth L
Abstract Background In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major...
Wang, Catharine, Gonzalez, Richard, Milliron, Kara J., Strecher, Victor J., Merajver, Sofia D.
Due to the complexity of information surrounding BRCA1 / 2 counseling and testing and its time consuming nature, efforts to facilitate the genetic counseling and education process are needed. Using a...
Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma (2004)
Marcus, Benjamin, Arenberg, Douglas A., Lee, Julia, Kleer, Celina G., Chepeha, Douglas B., Schmalbach, Cecelia E., ...
BACKGROUND The survival of patients with head and neck squamous cell carcinoma (HNSCC) remains unaffected despite recent therapeutic advances. To reverse this trend, reliable and clinically...
Merajver, Sofia D., Colpaert, C.G., Van Den Eynden, G.G., Van Laere, S., Van Dam, P., ...
Aims. Inflammatory breast cancer (IBC) is an aggressive subtype of breast cancer with poor prognosis. The mechanisms responsible for the aggressive clinical evolution are incompletely understood. We...
Merajver, Sofia D., Kumar-Sinha, Chandan, Wu, Mei, Wu, Zhi-Fen, Chinnaiyan, Arul M.
Inflammatory breast cancer (IBC) is the most deadly form of breast cancer in humans presumably due to its ability to metastasize from its inception. In our laboratory, overexpression of RhoC GTPase...
Kleer, Celina G, Zhang, Yanhong, Pan, Quintin, Gallagher, Gary, Wu, Mei, Wu, Zhi-Fen, ...
Abstract Background Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer. We found concordant and consistent alterations of two genes in 90% of IBC tumors when...
The most distal region of chromosome 17p between 17p13.3 and the telomere have been found to be independently deleted in several breast tumors. The overall goal of this project is to produce a...
Van Golen, Kenneth L., Wei Bao, Li, Pan, Quintin, Miller, Fred R., Fen Wu, Zhi, Merajver, Sofia D.
Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer known. IBC carries a guarded prognosis primarily due to rapid onset of disease, typically within six months,...
Trask, Peter C., Paterson, Amber G., Wang, Catharine, Hayasaka, Satoru, Milliron, Kara J., Blumberg, Laurie R., ...
Intrusive thoughts about cancer, often identified as ‘cancer-specific worries’ or ‘cancer-specific distress’, have been postulated to be associated with dysfunction in women at increased risk...
Kleer, Celina G, Van Golen, Kenneth L, Merajver, Sofia D
Abstract Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer (LABC) that effects approximately 5% of women with breast cancer annually in the USA. It is a...
Bilingual Educational Tool for Breast Cancer Genetics (1998)
The BRCA1 gene is responsible for an autosomal dominant syndrome of inherited susceptibility to breast and ovarian cancer. To date, over 100 disease-predisposing mutations have been identified in...
Merajver, Sofia D., Wicha, Max S.
Germilne mutations in breast cancer susceptibility genes account for 8% of all breast cancer cases. BRCA1 on 17q12 and BRCA2 on 13q12-13 are implicated in 50%-60% of breast cancer families. and they...
Germline mutations in breast cancer susceptibility genes account for 8% of all breast cancer cases. BRCAl on 17q12 and BRCA2 on 13q12-13 are implicated in 5O%-6O% of breast cancer families, and they...
Bilingual Educational Tool for Breast Cancer Genetics (1998)
The recognition and study of the BRCA genes associated with hereditary breast and ovarian cancer have led to the development of cancer genetics counseling as an important medical intervention....
Genetic Determinants of Inflammatory Breast Cancer (1998)
Primary inflammatory breast cancer (IBC) accounts for approximately 6% of new breast cancers annually. We hypothesize that a limited number of concordant genetic alterations give rise to the unique...
Genetic Determinants of Inflammatory Breast Cancer (1998)
Primary inflammatory breast cancer (IBC) accounts for approximately 6% of new breast cancers annually. We hypothesized that a limited number of concordant genetic alterations give rise to the unioue...
Genetic Determinants of Inflammatory Breast Cancer (1998)
Primary inflammatory breast cancer (IBC) accounts for approximately 6% of new breast cancers annually. We hypothesized that a limited number of concordant genetic alterations give rise to the unique...
Wicha, Max S., Merajver, Sofia D.
Germline mutations in breast cancer susceptibility genes account for 8% of all breast cancer cases. BRCA1 on 17q12 and BRCA2 on 13q12-13 are implicated in 50%-60% of breast cancer families, and they...
Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3 (1996)
Tissil, F., Couch, Fergus J., Szpirer, Josiane, Szpirer, C., Van Vooren, P., Simon, J.S., ...
Peer Reviewed
Transcript identification in the BRCA1 candidate region (1995)
Abel, Kenneth J., Couch, Fergus J., Merajver, Sofia D., Castilla, Lucio H., Brody, Lawrence C., Collins, Francis S., ...
Chromosome 17q12-21 is known to contain a gene (or genes) which confers susceptibility to early-onset breast cancer and ovarian cancer (BRCA1). Identification and isolation of BRCA1 will likely...
Merajver, Sofia D., Wunder, Stephanie L., Wallace, William
No Abstract.
Merajver, Sofia D., Wunder, Stephanie L., Wallace, William
Raman spectroscopy is used to investigate the conformation and packing of isotactic crystalline Α-phase polypropylene compared with lower-order Β-phase isotactic polypropylene and to study the...
Kleer, Celina G, Van Golen, Kenneth L, Merajver, Sofia D
Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer (LABC) that effects approximately 5% of women with breast cancer annually in the USA. It is a clinically and...
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer
Kleer, Celina G, Zhang, Yanhong, Pan, Quintin, Gallagher, Gary, Wu, Mei, Wu, Zhi-Fen, ...
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1
Lin, Min, DiVito, Melinda M, Merajver, Sofia D, Boyanapalli, Madanamohan, Van Golen, Kenneth L
The Polycomb Group Protein EZH2 Impairs DNA Repair in Breast Epithelial Cells1
Zeidler, Michael, Varambally, Sooryanarayana, Cao, Qi, Chinnaiyan, Arul M., Ferguson, David O., Merajver, Sofia D., ...
The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to aggressive and metastatic breast cancer. Here we report that EZH2...
Kleer, Celina G, Zhang, Yanhong, Pan, Quintin, Merajver, Sofia D
Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer. We have found that WISP3 is lost in 80% of human IBC tumors and that it has growth- and...
RhoC GTPase Overexpression Modulates Induction of Angiogenic Factors in Breast Cells1
Van Golen, Kenneth L, Wu, Zhi-Fen, Qiao, XiaoTan, Bao, LiWei, Merajver, Sofia D
Inflammatory breast cancer (IBC) is a distinct and aggressive form of locally advanced breast cancer. IBC is highly angiogenic, invasive, and metastatic at its inception. Previously, we identified...
Radiotherapy and Antiangiogenic TM in Lung Cancer
Khan, Mohamed K, Miller, Meredith W, Taylor, Jeremy, Gill, Navkiranjit K, Dick, Robert D, Van Golen, Kenneth, ...
Tetrathiomolybdate (TM) is a potent nontoxic orally delivered copper complexing agent under development for the last several years for the treatment of Wilson's disease. It has been shown to block...
Van Golen, Kenneth L, Bao, LiWei, Brewer, George J, Pienta, Kenneth J, Kamradt, Jeffrey M, Livant, Donna L, ...
Plasma fibronectin-mediated invasion of human DU145 prostate cancer cell line was efficaciously inhibited in a rat tumor model by treatment with Ac-PHSCN-NH2 peptide. Invasion of DU145 cells was...
Kleer, Celina G, Van Golen, Kenneth L, Merajver, Sofia D
Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer (LABC) that effects approximately 5% of women with breast cancer annually in the USA. It is a clinically and...
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer
Kleer, Celina G, Zhang, Yanhong, Pan, Quintin, Gallagher, Gary, Wu, Mei, Wu, Zhi-Fen, ...
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1
Lin, Min, DiVito, Melinda M, Merajver, Sofia D, Boyanapalli, Madanamohan, Van Golen, Kenneth L
The Polycomb Group Protein EZH2 Impairs DNA Repair in Breast Epithelial Cells1
Zeidler, Michael, Varambally, Sooryanarayana, Cao, Qi, Chinnaiyan, Arul M., Ferguson, David O., Merajver, Sofia D., ...
The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to aggressive and metastatic breast cancer. Here we report that EZH2...
Kleer, Celina G, Zhang, Yanhong, Pan, Quintin, Merajver, Sofia D
Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer. We have found that WISP3 is lost in 80% of human IBC tumors and that it has growth- and...
RhoC GTPase Overexpression Modulates Induction of Angiogenic Factors in Breast Cells1
Van Golen, Kenneth L, Wu, Zhi-Fen, Qiao, XiaoTan, Bao, LiWei, Merajver, Sofia D
Inflammatory breast cancer (IBC) is a distinct and aggressive form of locally advanced breast cancer. IBC is highly angiogenic, invasive, and metastatic at its inception. Previously, we identified...
Radiotherapy and Antiangiogenic TM in Lung Cancer
Khan, Mohamed K, Miller, Meredith W, Taylor, Jeremy, Gill, Navkiranjit K, Dick, Robert D, Van Golen, Kenneth, ...
Tetrathiomolybdate (TM) is a potent nontoxic orally delivered copper complexing agent under development for the last several years for the treatment of Wilson's disease. It has been shown to block...
Van Golen, Kenneth L, Bao, LiWei, Brewer, George J, Pienta, Kenneth J, Kamradt, Jeffrey M, Livant, Donna L, ...
Plasma fibronectin-mediated invasion of human DU145 prostate cancer cell line was efficaciously inhibited in a rat tumor model by treatment with Ac-PHSCN-NH2 peptide. Invasion of DU145 cells was...
Kleer, Celina G., Van Golen, Kenneth L., Zhang, Yanhong, Wu, Zhi-Fen, Rubin, Mark A., Merajver, Sofia D.
The most important factor in predicting outcome in patients with early breast cancer is the stage of the disease. There is no robust marker capable of identifying invasive carcinomas that despite...
BRCA1 regulates human mammary stem/progenitor cell fate
Liu, Suling, Ginestier, Christophe, Charafe-Jauffret, Emmanuelle, Foco, Hailey, Kleer, Celina G., Merajver, Sofia D., ...
Although it is well established that women with germ-line mutations in the BRCA1 gene have a greatly increased lifetime incidence of breast and ovarian cancer, the molecular mechanisms responsible...
Huang, Wei, Zhang, Yanhong, Varambally, Sooryanarayana, Chinnaiyan, Arul M., Banerjee, Mousumi, Merajver, Sofia D., ...
The cysteine-rich protein CCN6 [or Wnt-1-induced signaling protein 3 (WISP3)] exerts tumor-suppressive effects in aggressive inflammatory breast cancer. Loss of CCN6 is associated with poorly...