Sonia Holz-Smith

The role of the third β strand in gp120 conformation and neutralization sensitivity of the HIV-1 primary isolate DH012

Zhu, Chong-Bin, Zhu, Lei, Holz-Smith, Sonia, Matthews, Thomas J., Chen, Chin Ho

Neutralization of HIV-1 primary isolates has been a tremendous challenge for AIDS vaccine development. Here, we identify a single amino acid change (T198P) in gp120 that alters the neutralization...

Induction and Characterization of Neutralizing Antibodies against a Human Immunodeficiency Virus Type 1 Primary Isolate

Chen, Chin-Ho, Jin, Lei, Zhu, Chongbin, Holz-Smith, Sonia, Matthews, Thomas J.

Chimpanzees infected with the primary isolate DH012 mount potent neutralizing antibodies. This DH012 neutralizing activity is highly strain specific. Immune sera from guinea pigs immunized with...

The role of the third β strand in gp120 conformation and neutralization sensitivity of the HIV-1 primary isolate DH012

Zhu, Chong-Bin, Zhu, Lei, Holz-Smith, Sonia, Matthews, Thomas J., Chen, Chin Ho

Neutralization of HIV-1 primary isolates has been a tremendous challenge for AIDS vaccine development. Here, we identify a single amino acid change (T198P) in gp120 that alters the neutralization...

Induction and Characterization of Neutralizing Antibodies against a Human Immunodeficiency Virus Type 1 Primary Isolate

Chen, Chin-Ho, Jin, Lei, Zhu, Chongbin, Holz-Smith, Sonia, Matthews, Thomas J.

Chimpanzees infected with the primary isolate DH012 mount potent neutralizing antibodies. This DH012 neutralizing activity is highly strain specific. Immune sera from guinea pigs immunized with...