Susomboon, Pannapa, Iwagami, Moritoshi, Tangpukdee, Noppadon, Krusood, Srivicha, Looareesuwan, Sornchai, Kano, Shigeyuki
Abstract Background There have been many reports on the population genetic structures of Plasmodium falciparum from different endemic regions, but few studies have examined the characteristics of...
Nagao, Yoshiro, Kimura-Sato, Masako, Chavalitshewinkoon-Petmitr, Porntip, Thongrungkiat, Supatra, Wilairatana, Polrat, Ishida, Takafumi, ...
Abstract Background It has frequently been reported that Plasmodium vivax suppressed Plasmodium falciparum and ameliorated disease severity in patients infected with these two species simultaneously....
Phimpraphi, Waraphon, Paul, Richard E, Yimsamran, Surapon, Puangsa-art, Supalarp, Thanyavanich, Nipon, Maneeboonyang, Wanchai, ...
Abstract Background Clinical case treatment of malaria infections where Plasmodium falciparum and Plasmodium vivax are sympatric has achieved effective reductions in P. falciparum prevalence and...
Julie A. Simpson, Tsiri Agbenyega, Karen I. Barnes, Gianni Di Perri, Peter Folb, Melba Gomes, ...
BackgroundIntra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not...
Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1. (2006)
Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne Charlotte, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...
BACKGROUND: Plasmodium vivax is the second most prevalent malaria parasite affecting more than 75 million people each year, mostly in South America and Asia. In addition to major morbidity this...
Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1. (2006)
Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne Charlotte, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...
BACKGROUND: Plasmodium vivax is the second most prevalent malaria parasite affecting more than 75 million people each year, mostly in South America and Asia. In addition to major morbidity this...
Verena Ilona Carrara, Supakit Sirilak, Janjira Thonglairuam, Chaiporn Rojanawatsirivet, Stephane Proux, Valery Gilbos, ...
Artesunate-mefloquine therapy and rapid diagnosis were introduced in five border districts in northwestern Thailand. Cases, hospitalizations, and malaria-related deaths were recorded before, during,...
Verena Ilona Carrara, Supakit Sirilak, Janjira Thonglairuam, Chaiporn Rojanawatsirivet, Stephane Proux, Valery Gilbos, ...
Background Early diagnosis and treatment with artesunate-mefloquine combination therapy (MAS) have reduced the transmission of falciparum malaria dramatically and halted the progression of mefloquine...
Ohashi, Jun, Naka, Izumi, Doi, Akihiro, Patarapotikul, Jintana, Hananantachai, Hathairad, Tangpukdee, Noppadon, ...
Abstract Background IL-1β and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be...
Practical PCR genotyping protocols for Plasmodium vivaxusing Pvcsand Pvmsp1 (2005)
Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...
Abstract Background Plasmodium vivax is the second most prevalent malaria parasite affecting more than 75 million people each year, mostly in South America and Asia. In addition to major morbidity...
Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1. (2005)
Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne Charlotte, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...
BACKGROUND: Plasmodium vivax is the second most prevalent malaria parasite affecting more than 75 million people each year, mostly in South America and Asia. In addition to major morbidity this...
Sibmooh, Nathawut, Yamanont, Paveena, Krudsood, Srivicha, Leowattana, Wattana, Brittenham, Gary, Looareesuwan, Sornchai, ...
Abstract Introduction Oxidative stress has been demonstrated in malaria. The potential oxidative modification of lipoproteins derived from malaria patients was studied. These oxidized lipids may have...
Matsuo, Toshiaki, Shirakawa, Toshiro, Singhasivanon, Pratap, Looareesuwan, Sornchai, Kawabata, Masato
Matsuo, Toshiaki, Shirakawa, Toshiro, Singhasivanon, Pratap, Looareesuwan, Sornchai, Kawabata, Masato
Mathieu Nacher, Pratap Singhasivanon, Udomsak Silachamroon, Sombat Treeprasertsuk, Thanawat Tosukhowong, Suparp Vannaphan, ...
To determine factors influencing gametocyte carriage, a cross-sectional study was conducted among 512 patients admitted for Plasmodium falciparum malaria. After adjustments for potential confounders,...
Therapeutic Responses to Different Antimalarial Drugs in Vivax Malaria
Pukrittayakamee, Sasithon, Chantra, Arun, Simpson, Julie A., Vanijanonta, Sirivan, Clemens, Ralf, Looareesuwan, Sornchai, ...
The therapeutic responses to the eight most widely used antimalarial drugs were assessed in 207 adult patients with Plasmodium vivax malaria. This parasite does not cause marked sequestration, so...
Therapeutic Responses to Quinine and Clindamycin in Multidrug-Resistant Falciparum Malaria
Pukrittayakamee, Sasithon, Chantra, Arun, Vanijanonta, Sirivan, Clemens, Ralf, Looareesuwan, Sornchai, White, Nicholas J.
Therapeutic responses to clindamycin in combination with quinine were assessed in adult Thai patients with uncomplicated multidrug-resistant Plasmodium falciparum malaria. In total 204 patients were...
Imwong, Mallika, Pukrittakayamee, Sasithon, Looareesuwan, Sornchai, Pasvol, Geoffrey, Poirreiz, Jean, White, Nicholas J., ...
Mutations in the Plasmodium falciparum gene (dhfr) encoding dihydrofolate reductase are associated with resistance to antifols. Plasmodium vivax, the more prevalent malaria parasite in Asia and the...
Effects of α-Thalassemia on Pharmacokinetics of the Antimalarial Agent Artesunate
Ittarat, Wanida, Looareesuwan, Sornchai, Pootrakul, Pensri, Sumpunsirikul, Petchmanee, Vattanavibool, Phantip, Meshnick, Steven R.
Thalassemia is common in Southeast Asia, where artemisinin derivatives are frequently used in the treatment of malaria. It has been previously reported that artemisinin derivatives can be...
Newton, Paul N., Van Vugt, Michele, Teja-Isavadharm, Paktiya, Siriyanonda, Duangsuda, Rasameesoroj, Maneerat, Teerapong, Pramote, ...
Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial...
Imwong, Mallika, Pukrittayakamee, Sasithon, Looareesuwan, Sornchai, Pasvol, Geoffrey, Poirriez, Jean, White, Nicholas J., ...
Febrile temperatures induce cytoadherence of ring-stage Plasmodium falciparum-infected erythrocytes
Udomsangpetch, Rachanee, Pipitaporn, Busaba, Silamut, Kamolrat, Pinches, Robert, Kyes, Sue, Looareesuwan, Sornchai, ...
In falciparum malaria, the malaria parasite induces changes at the infected red blood cell surface that lead to adherence to vascular endothelium and other red blood cells. As a result, the more...
Imwong, Mallika, Pukrittayakamee, Sasithon, Rénia, Laurent, Letourneur, Franck, Charlieu, Jean-Paul, Leartsakulpanich, Ubolsree, ...
Mutations in the dihydrofolate reductase (dhfr) genes of Plasmodium falciparum and P. vivax are associated with resistance to the antifolate antimalarial drugs. P. vivax dhfr sequences were obtained...
Brockman, Alan, Singlam, Sittaporn, Phiaphun, Lucy, Looareesuwan, Sornchai, White, Nicholas J., Nosten, François
A double-site enzyme-linked lactate dehydrogenase enzyme immunodetection assay was tested against field isolates of Plasmodium falciparum for assessing in vitro drug susceptibilities to a wide range...
Pukrittayakamee, Sasithon, Chotivanich, Kesinee, Chantra, Arun, Clemens, Ralf, Looareesuwan, Sornchai, White, Nicholas J.
The activities of primaquine in combination with quinine or artesunate against asexual- and sexual-stage parasites were assessed in 176 adult Thai patients with uncomplicated Plasmodium falciparum...
Comparison of Artesunate and Chloroquine Activities against Plasmodium vivax Gametocytes
Nacher, Mathieu, Silachamroon, Udomsak, Singhasivanon, Pratap, Wilairatana, Polrat, Phumratanaprapin, Weerapong, Fontanet, Arnaud, ...
The gametocidal activities of chloroquine and artesunate were compared. The relative risk (RR) of having detectable gametocytes appear after treatment initiation was lower in artesunate-treated...
Sibmooh, Nathawut, Yamanont, Paveena, Krudsood, Srivicha, Leowattana, Wattana, Brittenham, Gary, Looareesuwan, Sornchai, ...
Brockman, Alan, Singlam, Sittaporn, Phiaphun, Lucy, Looareesuwan, Sornchai, White, Nicholas J., Nosten, François
In Vivo Assessment of Drug Efficacy against Plasmodium falciparum Malaria: Duration of Follow-Up
Stepniewska, Kasia, Taylor, Walter R.J., Mayxay, Mayfong, Price, Ric, Smithuis, Frank, Guthmann, Jean-Paul, ...
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28...
Pharmacokinetics of Oral Doxycycline during Combination Treatment of Severe Falciparum Malaria
Newton, Paul N., Chaulet, Jean-François, Brockman, Alan, Chierakul, Wirongrong, Dondorp, Arjen, Ruangveerayuth, Ronatrai, ...
The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of...
Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1
Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne Charlotte, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...
Ohashi, Jun, Naka, Izumi, Doi, Akihiro, Patarapotikul, Jintana, Hananantachai, Hathairad, Tangpukdee, Noppadon, ...
Imwong, Mallika, Pukrittayakamee, Sasithon, Cheng, Qin, Moore, Catrin, Looareesuwan, Sornchai, Snounou, Georges, ...
The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of...
Carrara, Verena Ilona, Sirilak, Supakit, Thonglairuam, Janjira, Rojanawatsirivet, Chaiporn, Proux, Stephane, Gilbos, Valery, ...
Artesunate-mefloquine therapy and rapid diagnosis were introduced in five border districts in northwestern Thailand. Cases, hospitalizations, and malaria-related deaths were recorded before, during,...
The treatment of severe falciparum malaria
Warrell, D A, White, N J, Looareesuwan, Sornchai, Phillips, R E, Warrell, M J, Bunnag, Danai, ...
Transmission-Blocking Activities of Quinine, Primaquine, and Artesunate
Chotivanich, Kesinee, Sattabongkot, Jetsumon, Udomsangpetch, Rachanee, Looareesuwan, Sornchai, Day, Nicholas P. J., Coleman, Russell E., ...
The infectivity of Plasmodium falciparum gametocytes after exposure in vitro to quinine, artesunate, and primaquine was assessed in Anopheles dirus, a major vector of malaria in Southeast Asia....
Simpson, Julie A, Agbenyega, Tsiri, Barnes, Karen I, Perri, Gianni Di, Folb, Peter, Gomes, Melba, ...
A study of the population pharmacokinetics of intra-rectal artesunate in patients with moderately severe falciparum malaria found the pharmacokinetic properties of dihydroartemisinin were affected...
Therapeutic Responses to Different Antimalarial Drugs in Vivax Malaria
Pukrittayakamee, Sasithon, Chantra, Arun, Simpson, Julie A., Vanijanonta, Sirivan, Clemens, Ralf, Looareesuwan, Sornchai, ...
The therapeutic responses to the eight most widely used antimalarial drugs were assessed in 207 adult patients with Plasmodium vivax malaria. This parasite does not cause marked sequestration, so...
Therapeutic Responses to Quinine and Clindamycin in Multidrug-Resistant Falciparum Malaria
Pukrittayakamee, Sasithon, Chantra, Arun, Vanijanonta, Sirivan, Clemens, Ralf, Looareesuwan, Sornchai, White, Nicholas J.
Therapeutic responses to clindamycin in combination with quinine were assessed in adult Thai patients with uncomplicated multidrug-resistant Plasmodium falciparum malaria. In total 204 patients were...
Imwong, Mallika, Pukrittakayamee, Sasithon, Looareesuwan, Sornchai, Pasvol, Geoffrey, Poirreiz, Jean, White, Nicholas J., ...
Mutations in the Plasmodium falciparum gene (dhfr) encoding dihydrofolate reductase are associated with resistance to antifols. Plasmodium vivax, the more prevalent malaria parasite in Asia and the...
Effects of α-Thalassemia on Pharmacokinetics of the Antimalarial Agent Artesunate
Ittarat, Wanida, Looareesuwan, Sornchai, Pootrakul, Pensri, Sumpunsirikul, Petchmanee, Vattanavibool, Phantip, Meshnick, Steven R.
Thalassemia is common in Southeast Asia, where artemisinin derivatives are frequently used in the treatment of malaria. It has been previously reported that artemisinin derivatives can be...
Newton, Paul N., Van Vugt, Michele, Teja-Isavadharm, Paktiya, Siriyanonda, Duangsuda, Rasameesoroj, Maneerat, Teerapong, Pramote, ...
Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial...
Imwong, Mallika, Pukrittayakamee, Sasithon, Looareesuwan, Sornchai, Pasvol, Geoffrey, Poirriez, Jean, White, Nicholas J., ...
Febrile temperatures induce cytoadherence of ring-stage Plasmodium falciparum-infected erythrocytes
Udomsangpetch, Rachanee, Pipitaporn, Busaba, Silamut, Kamolrat, Pinches, Robert, Kyes, Sue, Looareesuwan, Sornchai, ...
In falciparum malaria, the malaria parasite induces changes at the infected red blood cell surface that lead to adherence to vascular endothelium and other red blood cells. As a result, the more...
Imwong, Mallika, Pukrittayakamee, Sasithon, Rénia, Laurent, Letourneur, Franck, Charlieu, Jean-Paul, Leartsakulpanich, Ubolsree, ...
Mutations in the dihydrofolate reductase (dhfr) genes of Plasmodium falciparum and P. vivax are associated with resistance to the antifolate antimalarial drugs. P. vivax dhfr sequences were obtained...
Brockman, Alan, Singlam, Sittaporn, Phiaphun, Lucy, Looareesuwan, Sornchai, White, Nicholas J., Nosten, François
A double-site enzyme-linked lactate dehydrogenase enzyme immunodetection assay was tested against field isolates of Plasmodium falciparum for assessing in vitro drug susceptibilities to a wide range...
Pukrittayakamee, Sasithon, Chotivanich, Kesinee, Chantra, Arun, Clemens, Ralf, Looareesuwan, Sornchai, White, Nicholas J.
The activities of primaquine in combination with quinine or artesunate against asexual- and sexual-stage parasites were assessed in 176 adult Thai patients with uncomplicated Plasmodium falciparum...
CD36 Polymorphism Is Associated with Protection from Cerebral Malaria
Omi, Kazuya, Ohashi, Jun, Patarapotikul, Jintana, Hananantachai, Hathairad, Naka, Izumi, Looareesuwan, Sornchai, ...
The human protein CD36 is a major receptor for Plasmodium falciparum–infected erythrocytes and contributes to the pathology of P. falciparum malaria. We performed variation screening of the CD36...
Comparison of Artesunate and Chloroquine Activities against Plasmodium vivax Gametocytes
Nacher, Mathieu, Silachamroon, Udomsak, Singhasivanon, Pratap, Wilairatana, Polrat, Phumratanaprapin, Weerapong, Fontanet, Arnaud, ...
The gametocidal activities of chloroquine and artesunate were compared. The relative risk (RR) of having detectable gametocytes appear after treatment initiation was lower in artesunate-treated...
Sibmooh, Nathawut, Yamanont, Paveena, Krudsood, Srivicha, Leowattana, Wattana, Brittenham, Gary, Looareesuwan, Sornchai, ...
Brockman, Alan, Singlam, Sittaporn, Phiaphun, Lucy, Looareesuwan, Sornchai, White, Nicholas J., Nosten, François
In Vivo Assessment of Drug Efficacy against Plasmodium falciparum Malaria: Duration of Follow-Up
Stepniewska, Kasia, Taylor, Walter R.J., Mayxay, Mayfong, Price, Ric, Smithuis, Frank, Guthmann, Jean-Paul, ...
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28...
Pharmacokinetics of Oral Doxycycline during Combination Treatment of Severe Falciparum Malaria
Newton, Paul N., Chaulet, Jean-François, Brockman, Alan, Chierakul, Wirongrong, Dondorp, Arjen, Ruangveerayuth, Ronatrai, ...
The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of...
Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1
Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne Charlotte, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...
Extended Linkage Disequilibrium Surrounding the Hemoglobin E Variant Due to Malarial Selection
Ohashi, Jun, Naka, Izumi, Patarapotikul, Jintana, Hananantachai, Hathairad, Brittenham, Gary, Looareesuwan, Sornchai, ...
The hemoglobin E variant (HbE; β26Glu→Lys) is concentrated in parts of Southeast Asia where malaria is endemic, and HbE carrier status has been shown to confer some protection against Plasmodium...