Kyra Oswald-Richter, Stacy M. Grill, Mindy Leelawong, Michelle Tseng, Spyros A. Kalams, Todd Hulgan, ...
Infection with HIV-1 perturbs homeostasis of human T cell subsets, leading to accelerated immunologic deterioration. While studying changes in CD4+ memory and naïve T cells during HIV-1 infection,...
Determinants of HIV-1 Mutational Escape From Cytotoxic (1365)
T Lymphocytes, Otto O. Yang, Christian Brander, Spyros A. Kalams, Ayub Ali, Bruce D. Walker, ...
CD8� class I–restricted cytotoxic T lymphocytes (CTLs) usually incompletely suppress HIV-1 in vivo, and while analogous partial suppression induces antiretroviral drug-resistance mutations,...
Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells
Yang, Otto O., Tran, Annie-Chen, Kalams, Spyros A., Johnson, R. Paul, Roberts, Margo R., Walker, Bruce D.
Increasing evidence suggests that HIV-1-specific cytotoxic T lymphocytes (CTLs) are a key host immune response to HIV-1 infection. Generation of CTL responses for prevention or therapy of HIV-1...
Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity
Flores-Villanueva, Pedro O., Yunis, Edmond J., Delgado, Julio C., Vittinghoff, Eric, Buchbinder, Susan, Leung, Jessica Y., ...
Certain HLA-B antigens have been associated with lack of progression to AIDS. HLA-B alleles can be divided into two mutually exclusive groups based on the expression of the molecular epitopes HLA-Bw4...
Severino, Michael E., Sipsas, Nikolaos V., Nguyen, Phuong Thi, Kalams, Spyros A., Walker, Bruce D., Johnson, R. Paul, ...
We demonstrate that human immunodeficiency virus type 1 (HIV-1)-specific CD8+ cytotoxic T lymphocytes (CTL) suppress HIV-1 replication in primary lymphocytes, monocytes, and dendritic cells...
Kalams, Spyros A., Buchbinder, S. P., Rosenberg, E. S., Billingsley, J. M., Colbert, D. S., Jones, N. G., ...
Cellular immune responses are thought to be an important antiviral host defense, but the relationship between virus-specific T-helper and cytotoxic-T-lymphocyte (CTL) responses has not been defined....
Kalams, Spyros A., Goulder, Philip J., Shea, Amy K., Jones, Norman G., Trocha, Alicja K., Ogg, Graham S., ...
Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidate interactions between the host cellular immune responses and HIV-1 infection. We performed a...
Brander, Christian, Yang, Otto O., Jones, Norman G., Lee, Yun, Goulder, Philip, Johnson, R. Paul, ...
Immune escape from cytotoxic T-lymphocyte (CTL) responses has been shown to occur not only by changes within the targeted epitope but also by changes in the flanking sequences which interfere with...
Altfeld, Marcus A., Livingston, Brian, Reshamwala, Neha, Nguyen, Phuong T., Addo, Marylyn M., Shea, Amy, ...
Virus-specific cytotoxic T-lymphocyte (CTL) responses are critical in the control of human immunodeficiency virus type 1 (HIV-1) infection and will play an important part in therapeutic and...
Islam, Sabina A., Hay, Christine M., Hartman, Kelly E., He, Suqin, Shea, Amy K., Trocha, Alicja K., ...
We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive...
Day, Cheryl L., Shea, Amy K., Altfeld, Marcus A., Olson, Douglas P., Buchbinder, Susan P., Hecht, Frederick M., ...
Cytotoxic T lymphocytes (CTL) target multiple epitopes in human immunodeficiency virus (HIV)-infected persons, and are thought to influence the viral set point. The extent to which HLA class I allele...
Altfeld, Marcus A., Trocha, Alicja, Eldridge, Robert L., Rosenberg, Eric S., Phillips, Mary N., Addo, Marylyn M., ...
Human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T-lymphocyte (CTL) responses play a major role in the antiviral immune response, but the relative contribution of CTL responses...
Nef-Mediated Resistance of Human Immunodeficiency Virus Type 1 to Antiviral Cytotoxic T Lymphocytes
Yang, Otto O., Nguyen, Phuong Thi, Kalams, Spyros A., Dorfman, Tanya, Göttlinger, Heinrich G., Stewart, Sheila, ...
Although Nef has been proposed to effect the escape of human immunodeficiency virus type 1 (HIV-1) from cytotoxic T lymphocytes (CTL) through downmodulation of major histocompatibility complex class...
Koibuchi, Tomohiko, Allen, Todd M., Lichterfeld, Mathias, Mui, Stanley K., O'Sullivan, Kristin M., Trocha, Alicja, ...
Studies in acute human immunodeficiency virus type 1 (HIV-1) infection indicate viral evolution under CD8 T-cell immune selection pressure, but the effects of ongoing immune pressure on epitope...
Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells
Yang, Otto O., Tran, Annie-Chen, Kalams, Spyros A., Johnson, R. Paul, Roberts, Margo R., Walker, Bruce D.
Increasing evidence suggests that HIV-1-specific cytotoxic T lymphocytes (CTLs) are a key host immune response to HIV-1 infection. Generation of CTL responses for prevention or therapy of HIV-1...
Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity
Flores-Villanueva, Pedro O., Yunis, Edmond J., Delgado, Julio C., Vittinghoff, Eric, Buchbinder, Susan, Leung, Jessica Y., ...
Certain HLA-B antigens have been associated with lack of progression to AIDS. HLA-B alleles can be divided into two mutually exclusive groups based on the expression of the molecular epitopes HLA-Bw4...
Severino, Michael E., Sipsas, Nikolaos V., Nguyen, Phuong Thi, Kalams, Spyros A., Walker, Bruce D., Johnson, R. Paul, ...
We demonstrate that human immunodeficiency virus type 1 (HIV-1)-specific CD8+ cytotoxic T lymphocytes (CTL) suppress HIV-1 replication in primary lymphocytes, monocytes, and dendritic cells...
Kalams, Spyros A., Buchbinder, S. P., Rosenberg, E. S., Billingsley, J. M., Colbert, D. S., Jones, N. G., ...
Cellular immune responses are thought to be an important antiviral host defense, but the relationship between virus-specific T-helper and cytotoxic-T-lymphocyte (CTL) responses has not been defined....
Kalams, Spyros A., Goulder, Philip J., Shea, Amy K., Jones, Norman G., Trocha, Alicja K., Ogg, Graham S., ...
Therapeutic suppression of human immunodeficiency virus type 1 (HIV-1) replication may help elucidate interactions between the host cellular immune responses and HIV-1 infection. We performed a...
Brander, Christian, Yang, Otto O., Jones, Norman G., Lee, Yun, Goulder, Philip, Johnson, R. Paul, ...
Immune escape from cytotoxic T-lymphocyte (CTL) responses has been shown to occur not only by changes within the targeted epitope but also by changes in the flanking sequences which interfere with...
Altfeld, Marcus A., Livingston, Brian, Reshamwala, Neha, Nguyen, Phuong T., Addo, Marylyn M., Shea, Amy, ...
Virus-specific cytotoxic T-lymphocyte (CTL) responses are critical in the control of human immunodeficiency virus type 1 (HIV-1) infection and will play an important part in therapeutic and...
Islam, Sabina A., Hay, Christine M., Hartman, Kelly E., He, Suqin, Shea, Amy K., Trocha, Alicja K., ...
We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive...
Day, Cheryl L., Shea, Amy K., Altfeld, Marcus A., Olson, Douglas P., Buchbinder, Susan P., Hecht, Frederick M., ...
Cytotoxic T lymphocytes (CTL) target multiple epitopes in human immunodeficiency virus (HIV)-infected persons, and are thought to influence the viral set point. The extent to which HLA class I allele...
Altfeld, Marcus A., Trocha, Alicja, Eldridge, Robert L., Rosenberg, Eric S., Phillips, Mary N., Addo, Marylyn M., ...
Human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T-lymphocyte (CTL) responses play a major role in the antiviral immune response, but the relative contribution of CTL responses...
Nef-Mediated Resistance of Human Immunodeficiency Virus Type 1 to Antiviral Cytotoxic T Lymphocytes
Yang, Otto O., Nguyen, Phuong Thi, Kalams, Spyros A., Dorfman, Tanya, Göttlinger, Heinrich G., Stewart, Sheila, ...
Although Nef has been proposed to effect the escape of human immunodeficiency virus type 1 (HIV-1) from cytotoxic T lymphocytes (CTL) through downmodulation of major histocompatibility complex class...
Koibuchi, Tomohiko, Allen, Todd M., Lichterfeld, Mathias, Mui, Stanley K., O'Sullivan, Kristin M., Trocha, Alicja, ...
Studies in acute human immunodeficiency virus type 1 (HIV-1) infection indicate viral evolution under CD8 T-cell immune selection pressure, but the effects of ongoing immune pressure on epitope...
Lebedeva, Tatiana, Anikeeva, Nadja, Kalams, Spyros A, Walker, Bruce D, Gaidarov, Ibragim, Keen, James H, ...
Polarization and segregation of the T-cell receptor (TCR) and integrins upon productive cytotoxic T-lymphocyte (CTL) target cell encounters are well documented. Much less is known about the...
Identification of a CCR5-Expressing T Cell Subset That Is Resistant to R5-Tropic HIV Infection
Oswald-Richter, Kyra, Grill, Stacy M, Leelawong, Mindy, Tseng, Michelle, Kalams, Spyros A, Hulgan, Todd, ...
Infection with HIV-1 perturbs homeostasis of human T cell subsets, leading to accelerated immunologic deterioration. While studying changes in CD4+ memory and naïve T cells during HIV-1 infection,...
Cellular Recognition of Mycobacterium tuberculosis ESAT-6 and KatG Peptides in Systemic Sarcoidosis▿
Drake, Wonder P., Dhason, Mary S., Nadaf, Michele, Shepherd, Bryan E., Vadivelu, Sangeetha, Hajizadeh, Rana, ...
Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood...
Meyer-Olson, Dirk, Brady, Kristen W., Bartman, Melissa T., O'Sullivan, Kristin M., Simons, Brenna C., Conrad, Joseph A., ...
T-cell receptor (TCR) diversity of virus-specific CD8+ T cells likely helps prevent escape mutations in chronic viral infections. To understand the dynamics of the virus-specific T cells in more...
Limited T Cell Receptor Diversity of HCV-specific T Cell Responses Is Associated with CTL Escape
Meyer-Olson, Dirk, Shoukry, Naglaa H., Brady, Kristen W., Kim, Helen, Olson, Douglas P., Hartman, Kelly, ...
Escape mutations are believed to be important contributors to immune evasion by rapidly evolving viruses such as hepatitis C virus (HCV). We show that the majority of HCV-specific cytotoxic T...
Determinants of HIV-1 Mutational Escape From Cytotoxic T Lymphocytes
Yang, Otto O., Sarkis, Phuong Thi Nguyen, Ali, Ayub, Harlow, Jason D., Brander, Christian, Kalams, Spyros A., ...
CD8+ class I–restricted cytotoxic T lymphocytes (CTLs) usually incompletely suppress HIV-1 in vivo, and while analogous partial suppression induces antiretroviral drug-resistance mutations, epitope...
Goulder, Philip J.R., Altfeld, Marcus A., Rosenberg, Eric S., Nguyen, Thi, Tang, Yanhua, Eldridge, Robert L., ...
Cytotoxic T lymphocytes (CTLs) play a vital part in controlling viral replication during human viral infections. Most studies in human infections have focused on CTL specificities in chronic...
Goulder, Philip J.R., Tang, Yanhua, Brander, Christian, Betts, Michael R., Altfeld, Marcus, Annamalai, Ken, ...
The highly sensitive quantitation of virus-specific CD8+ T cells using major histocompatibility complex–peptide tetramer assays has revealed higher levels of cytotoxic T lymphocytes (CTLs) in acute...
Antons, Amanda K., Wang, Rui, Kalams, Spyros A., Unutmaz, Derya
Regulatory T cells (Tregs) suppress immune responses against both self and non-self antigens. Tregs require activation through the T cell receptor (TCR) and IL-2 to exert their suppressive functions....
Ramalingam, Ramesh K., Meyer-Olson, Dirk, Shoukry, Naglaa H., Bowen, David G., Walker, Christopher M., Kalams, Spyros A.
Intrahepatic virus-specific CD8+ T cells are thought to be important for the control of hepatitis C virus (HCV) infection, yet the precise kinetics for the expansion of epitope-specific T cells over...
Sadagopal, Shanmugalakshmi, Lorey, Shelly L., Barnett, Louise, Basham, Rebecca, Lebo, Laurie, Erdem, Husamettin, ...
During untreated human immunodeficiency virus type 1 (HIV-1) infection, virus-specific CD8+ T cells partially control HIV replication in peripheral lymphoid tissues, but host mechanisms of HIV...