6Department of Oncology (2009)
Justin Lamb, Sridhar Ramaswamy, Heide L. Ford, Bernardo Contreras, Robert V. Martinez, Frances S. Kittrell, ...
Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Com-putational analysis of the expression patterns...
A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression (2009)
Yu, Min, Smolen, Gromoslaw A., Zhang, Jianmin, Wittner, Ben, Schott, Benjamin J., Brachtel, Elena, ...
Epithelial-to-mesenchymal transition (EMT) plays an important role during normal embryogenesis, and it has been implicated in cancer invasion and metastasis. Here, we report that Ladybird homeobox 1...
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 (2009)
Barbie, David A., Tamayo, Pablo, Boehm, Jesse S., Kim, So Young, Moody, Susan E., Dunn, Ian F., ...
Abstract Selectivity Estimation in Spatial Databases (2008)
Swarup Acharya, Viswanath Poosala, Sridhar Ramaswamy
swarup,poosala¢ Selectivity estimation of queries is an important and wellstudied problem in relational database systems. In this paper, we examine selectivity estimation in the context of...
Gregory Piatetsky-shapiro, Tom Khabaza, Sridhar Ramaswamy
Analyzing gene expression data from microarray devices has many important applications in medicine and biology, but presents significant challenges to data mining. Microarray data typically has many...
Abstract Selectivity Estimation in Spatial Databases (2008)
Swarup Acharya, Viswanath Poosala, Sridhar Ramaswamy
Selectivity estimation of queries is an important and well-studied problem in relational database systems. In this paper, we examine selectivity estimation in the context of Geographic Information...
Abstract Efficient Algorithms for Mining Outliers from Large Data Sets (2008)
In this paper, we propose a novel formulation for distance-based outliers that is based on the distance of a point from its £¥¤§ ¦ nearest neighbor. We rank each point on the basis of its...
Paris Kanellakis, Sridhar Ramaswamy, Darren Vengroff, Jeffrey Vitter
We examine I/O-efficient data structures that provide indexing support for new data models. The database languages of these models include concepts from constraint programming (e.g., relational...
Paris Kanellakis, Sridhar Ramaswamy, Darren Vengroff, Jeffrey Vitter
We examine I/O-efficient data structures that provide indexing support for new data models. The database languages of these models include concepts from constraint programming (e.g., relational...
Sridhar Ramaswamy, Rajeev Rastogi, Kyuseok Shim
In this paper, we propose a novel formulation for distance-based outliers that is based on the distance of a point from its k th nearest neighbor. We rank each point on the basis of its distance to...
Pages 1--7 Molecular classification of multiple tumor types (2007)
Chen-hsiang Yeang, Sridhar Ramaswamy, Pablo Tamayo, Ryan M. Rifkin, Michael Angelo, Michael Reich, ...
Vol. 1 no. 1 2001
SUPPLEMENTARY INFORMATION Multi-class Cancer Diagnosis Using Tumor Gene Expression Signatures (2007)
Sridhar Ramaswamy, Pablo Tamayo, Ryan Rifkin, Sayan Mukherjee, Hsiang Yeang, ...
This document provides supplementary information and details not included in the paper "Multiclass Cancer Diagnosis Using Tumor Gene Expression Signatures." Other sources of information can...
Zhigang C. Wang, Ming Lin, Lee-jen Wei, Cheng Li, Er Miron, Gabriella Lodeiro, ...
Gene expression array profiles identify subclasses of breast cancers with different clinical outcomes and different molecular features. The present study attempted to correlate genomic alterations...
An analytical method for multiclass molecular cancer classification (2003)
Ryan Rifkin, Sayan Mukherjee, Pablo Tamayo, Sridhar Ramaswamy, Chen-hsiang Yeang, Michael Angelo, ...
Abstract. Modern cancer treatment relies upon microscopic tissue examination to classify tumors according to anatomical site of origin. This approach is effective but subjective and variable even...
Gavin J. Gordon, Roderick V. Jensen, Li-li Hsiao, Steven R. Gullans, Joshua E. Blumenstock, Sridhar Ramaswamy, ...
The pathological distinction between malignant pleural mesothelioma (MPM) and adenocarcinoma (ADCA) of the lung can be cumbersome using established methods. We propose that a simple technique, based...
Molecular Classification of Multiple Tumor Types (2001)
Chen-Hsiang Yeang, Sridhar Ramaswamy, Pablo Tamayo, Sayan Mukherjee, Ryan M. Rifkin, Michael Angelo, ...
Using gene expression data to classify tumor types is a very promising tool in cancer diagnosis. Previous works show several pairs of tumor types can be successfully distinguished by their gene...
Molecular classification of multiple tumor types (2001)
Yeang, Chen-Hsiang, Ramaswamy, Sridhar, Tamayo, Pablo, Mukherjee, Sayan, Rifkin, Ryan M., Angelo, Michael, ...
Using gene expression data to classify tumor types is a very promising tool in cancer diagnosis. Previous works show several pairs of tumor types can be successfully distinguished by their gene...
Thesis (M.S.)--Ohio University, June, 2000.
An investigation of integrated global positioning system and inertial navigation system fault detection
An investigation of integrated global positioning system and inertial navigation system fault detection
A unified approach for indexed and non-indexed spatial joins (2000)
Lars Arge, Octavian Procopiuc, Sridhar Ramaswamy, Torsten Suel, Jan Vahrenhold, Jeffrey Scott Vitter
Abstract. Most spatial join algorithms either assume the existence of a spatial index structure that is traversed during the join process,or solve the problem by sorting, partitioning, or on-the-fly...
A Unified Approach For Indexed and Non-Indexed Spatial Joins (2000)
Lars Arge, Octavian Procopiuc, Sridhar Ramaswamy, Jeffrey Scott Vitter, Jan Vahrenhold, Torsten Suel
A large number of spatial join algorithms have been proposed over the last few years. Most of the algorithms can be broadly categorized into two approaches. The first approach assumes the existence...
A Unified Approach For Indexed and (2000)
Lars Arge, Octavian Procopiuc, Sridhar Ramaswamy, Torsten Suel, Jeffrey Scott Vitter
Most spatial join algorithms either assume the existence of a spatial index structure that is traversed during the join process, or solve the problem by sorting, partitioning, or on-the-fly index...
A unified approach for indexed and non-indexed spatial joins (2000)
Lars Arge, Octavian Procopiuc, Sridhar Ramaswamy, Torsten Suel, Jan Vahrenhold, Jeffrey Scott Vitter
Abstract. Most spatial join algorithms either assume the existence of a spatial index structure that is traversed during the join process,or solve the problem by sorting, partitioning, or on-the-fly...
Join synopses for approximate query answering (1999)
Swarup Acharya, Phillip B. Gibbons, Viswanath Poosala, Sridhar Ramaswamy
In large data warehousing environments, it is often advantageous to provide fast, approximate answers to complex aggregate queries based on statistical summaries of the full data. In this paper, we...
On the discovery of interesting patterns in association rules (1998)
Sridhar Ramaswamy, Sameer Mahajan
Many decision support systems, which utilize associ-ation rules for discovering interesting patterns, require the discovery of association rules that vary over time. Such rules describe complicated...
On the discovery of interesting patterns in association rules (1998)
Many decision support systems, which utilize association rules for discovering interesting patterns, require the discovery of association rules that vary over time. Such rules describe complicated...
Scalable Sweeping-Based Spatial Join (1998)
Lars Arge, Octavian Procopiuc, Sridhar Ramaswamy, Torsten Suel, Jeffrey Scott Vitter
In this paper, we consider the filter step of the spatial join problem, for the case where neither of the inputs are indexed. We present a new algorithm, Scalable Sweeping-Based Spatial Join (SSSJ),...
A constraint-based spatial extension to SQL (1998)
Gabriel Kuper, Sridhar Ramaswamy, Kyuseok Shim, Jianwen Su
The constraint database model provides a uniform framework for handling spatial and non-spatial data. We describe our proposal for a query language for GISs based on this model. Our language is...
Scalable Sweeping-Based Spatial Join (1998)
Lars Arge, Octavian Procopiuc, Sridhar Ramaswamy, Torsten Suel, Jeffrey Scott Vitter
In this paper, we consider the filter step of the spatial join problem, for the case where neither of the inputs are indexed. We present a new algorithm, Scalable Sweeping-Based Spatial Join (SSSJ),...
Scalable Sweeping-Based Spatial Join (1998)
Lars Arge, Octavian Procopiuc, Sridhar Ramaswamy, Torsten Suel, Jeffrey Scott Vitter
In this paper, we examine the spatial join problem. In particular, we focus on the case when neither of the inputs is indexed. We present a new algorithm, Scalable Sweep-based Spatial Join (SSSJ),...
A Constraint-based Spatial Extension to SQL (1998)
Gabriel Kuper, Sridhar Ramaswamy, Kyuseok Shim, Jianwen Su
The constraint database model provides a uniform framework for handling spatial and non-spatial data. We describe our proposal for a query language for GISs based on this model. Our language is...
Extend Ed, Lars Arge, Octavian Procopiuc, Sridhar Ramaswamy, Torsten Suel, Jeffrey Scott Vitter
) Lars Arge Octavian Procopiuc y Sridhar Ramaswamy z Torsten Suel x Jeffrey Scott Vitter -- Abstract We describe a powerful framework for designing efficient batch algorithms for certain large-scale...
Lars Arge, Octavian Procopiuc, Sridhar Ramaswamy, Torsten Suel, Jeffrey Scott Vitter
We describe a powerful framework for designing efficient batch algorithms for certain large-scale dynamic problems that must be solved using external memory. The class of problems we consider, which...
Efficient Indexing for Constraint and Temporal Databases (1997)
. We examine new I/O-efficient techniques for indexing problems in constraint and temporal data models. We present algorithms for these problems that are considerably simpler than previous solutions....
Printout.
Indexing for data models with classes and constraints /--by Sridhar Ramaswamy. (1995)
Available in film copy from University Microfilms International.
OODB Indexing by Class-Division (1995)
Sridhar Ramaswamy Paris, Sridhar Ramaswamy, Paris C. Kanellakis, Paris C. Kanellakis
Indexing a class hierarchy, in order to efficiently search or update the objects of a class according to a (range of) value(s) of an attribute, impacts OODB performance heavily. For this indexing...
OODB Indexing by Class-Division (1995)
Sridhar Ramaswamy, Paris C. Kanellakis
Indexing a class hierarchy, in order to efficiently search or update the objects of a class according to a (range of) value(s) of an attribute, impacts OODB performance heavily. For this indexing...
Path Caching: A Technique for Optimal External Searching (1994)
Sridhar Ramaswamy, Sridhar Ramaswamy, Sairam Subramanian, Sairam Subramanian
) Sridhar Ramaswamy Brown University sr@cs.brown.edu Sairam Subramanian y Brown University ss@cs.brown.edu Abstract External 2-dimensional searching is a fundamental problem with many applications in...
Functional Programming Formalisms for OODB Methods (1994)
Gerd Hillebrand, Paris Kanellakis, Sridhar Ramaswamy
. Two well-studied functional formalisms in the theory of programming languages are (1) applicative program schemas and (2) typed lambda calculi. We relate these programming formalisms to...
Indexing for Data Models with Constraints and Classes (1993)
Paris Kanellakis, Paris Kanellakis, Sridhar Ramaswamy, Sridhar Ramaswamy, Darren Vengroff, Darren Vengroff, ...
We examine I/O-efficient data structures that provide indexing support for new data models. The database languages of these models include concepts from constraint programming (e.g., relational...
Indexing for Data Models with Constraints and Classes (1993)
Jeffrey S. Vitter, Extended Abstract, Paris C. Kanellakis, Sridhar Ramaswamy, Darren E. Vengroff, Jeffrey S. Vitter
We examine I/O-efficient data structures that provide indexing support for new data models. The database languages of these models include concepts from constraint programming (e.g., relational...
Indexing for Data Models with Constraints and Classes (1993)
Jeffrey Scott Vitter, Paris Kanellakis Sridhar, Paris Kanellakis, Sridhar Ramaswamy, Sridhar Ramaswamy, Darren Vengroff, ...
We examine I/O-efficient data structures that provide indexing support for new data models. The database languages of these models include concepts from constraint programming (e.g., relational...
Indexing for Data Models with Constraints and Classes (1993)
Extend Ed, Paris C. Kanellakis, Sridhar Ramaswamy, Darren E. Vengroff, Jeffrey S. Vitter
) Paris C. Kanellakis Sridhar Ramaswamy y Darren E. Vengroff z Jeffrey S. Vitter x Abstract We examine I/O-efficient data structures that provide indexing support for new data models. The database...
Indexing for data models with constraints and classes (1993)
Paris Kanellakis, Sridhar Ramaswamy, Darren Vengro, Je Vitter
We examine I/O-e cient data structures that provide indexing support for new data models. The database languages of these models include concepts from constraint programming (e.g., relational tuples...
A Cooperative Transaction Model for Design Databases (1992)
Marian H. Nodine, Marian H. Nodine, Sridhar Ramaswamy, Sridhar Ramaswamy, Stanley B. Zdonik, Stanley B. Zdonik
this paper is organized as follows: Section 3.2 explains some desirable characteristics of a model for design transactions. Section 3.3 describes our cooperative transaction model. Section 3.4...
Paris Kanellakis, Sridhar Ramaswamy, Emmanuel Waller, Serge Abiteboul, Serge Abiteboul
A method schema is a simple programming formalism for object-oriented databases with features such as classes, methods, inheritance, name overloading, and late binding. An important problem is to...
Cloning of the escherichia coli lexA gene in bacillus subtilis /--by Sridhar Ramaswamy. (1987)
Thesis (B.A.)--Williams College, Dept. of Chemistry, 1987.
Multiclass cancer diagnosis using tumor gene expression signatures
Ramaswamy, Sridhar, Tamayo, Pablo, Rifkin, Ryan, Mukherjee, Sayan, Yeang, Chen-Hsiang, Angelo, Michael, ...
The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data. In some instances, this task is...
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer
Signoretti, Sabina, Di Marcotullio, Lucia, Richardson, Andrea, Ramaswamy, Sridhar, Isaac, Beth, Rue, Montserrat, ...
Estrogen receptor (ER) expression and Her-2 amplification define specific subsets of breast tumors for which specific therapies exist. The S-phase kinase-associated protein Skp2 is required for the...
Multiclass cancer diagnosis using tumor gene expression signatures
Ramaswamy, Sridhar, Tamayo, Pablo, Rifkin, Ryan, Mukherjee, Sayan, Yeang, Chen-Hsiang, Angelo, Michael, ...
The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data. In some instances, this task is...
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer
Signoretti, Sabina, Di Marcotullio, Lucia, Richardson, Andrea, Ramaswamy, Sridhar, Isaac, Beth, Rue, Montserrat, ...
Estrogen receptor (ER) expression and Her-2 amplification define specific subsets of breast tumors for which specific therapies exist. The S-phase kinase-associated protein Skp2 is required for the...
Du, Jinyan, Miller, Arlo J., Widlund, Hans R., Horstmann, Martin A., Ramaswamy, Sridhar, Fisher, David E.
The clinically important melanoma diagnostic antibodies HMB-45, melan-A, and MITF (D5) recognize gene products of the melanocyte-lineage genes SILV/PMEL17/GP100, MLANA/MART1, and MITF, respectively....
A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression
Yu, Min, Smolen, Gromoslaw A., Zhang, Jianmin, Wittner, Ben, Schott, Benjamin J., Brachtel, Elena, ...
Epithelial-to-mesenchymal transition (EMT) plays an important role during normal embryogenesis, and it has been implicated in cancer invasion and metastasis. Here, we report that Ladybird homeobox 1...
Systematic RNA interference reveals that oncogenic KRASdriven cancers require TBK1
Barbie, David A., Tamayo, Pablo, Boehm, Jesse S., Kim, So Young, Moody, Susan E., Dunn, Ian F., ...
Systems-Level Modeling of Cancer-Fibroblast Interaction
Wadlow, Raymond C., Wittner, Ben S., Finley, S. Aidan, Bergquist, Henry, Upadhyay, Rabi, Finn, Stephen, ...
Cancer cells interact with surrounding stromal fibroblasts during tumorigenesis, but the complex molecular rules that govern these interactions remain poorly understood thus hindering the development...
Coser, Kathryn R., Wittner, Ben S., Rosenthal, Noël F., Collins, Sabrina C., Melas, Antonia, Smith, Shannon L., ...
Emergence of antiestrogen-resistant cells in MCF-7 cells during suppression of estrogen signaling is a widely accepted model of acquired breast cancer resistance to endocrine therapy. To obtain...