Srinivas V. Kaveri

Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia (2009)

Wootla, Bharath, Mahendra, Ankit, Dimitrov, Jordan D, Friboulet, Alain, Borel-Derlon, Annie, Rao, Desirazu N, ...

Anti-factor VIII (FVIII) inhibitory IgG may arise as alloantibodies to therapeutic FVIII in patients with congenital hemophilia A, or as autoantibodies to endogenous FVIII in individuals with...

Immune response against therapeutic factor VIII in hemophilia A patients—A survey of probable risk factors (2007)

Dasgupta, Suryasarathi, Navarrete, Ana-Maria, Delignat, Sandrine, Wootla, Bharath, Andre, Sebastien, Nagaraja, Valakunja, ...

A number of diseases are treated by passive administration of human proteins. Human coagulation factor VIII (FVIII) is one such protein which is adminsitered to hemophilia A patients in order to...

VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors (2007)

Repesse, Yohann, Bayry, Jagadeesh, Navarrete, Ana-Maria, Wootla, Bharath, Delignat, Sandrine, ...

Von Willebrand factor (VWF) is a chaperone molecule for procoagulant factor VIII (FVIII). Its role in the reduction of the immunogenicity of therapeutic FVIII in patients with hemophilia A has been...

Immune response against therapeutic factor VIII in hemophilia A patients—A survey of probable risk factors (2007)

Dasgupta, Suryasarathi, Navarrete, Ana-Maria, Delignat, Sandrine, Wootla, Bharath, Andre, Sebastien, Nagaraja, Valakunja, ...

A number of diseases are treated by passive administration of human proteins. Human coagulation factor VIII (FVIII) is one such protein which is adminsitered to hemophilia A patients in order to...

Physiopathology of catalytic antibodies:the case for factor VIII-hydrolyzing immunoglobulin G (2006)

Bharath, Wootla, Dasgupta, Suryasarathi, Mallet, Vincent, Kazatchkine, Michel D, Nagaraja, Valakunja, Friboulet, Alain, ...

Antibodies that are able to catalyze the antigen for which they are specific are produced spontaneously by the immune system. Catalytic immunoglobulins (Igs) both of the IgM and IgG isotypes have...

Analysis of natural and disease-associated autoantibody repertoires: anti-endothelial cell IgG autoantibody activity in the serum of healthy individuals and patients with systemic lupus erythematosus (1994)

Ronda, Nicoletta, Haury, Mattias, Nobrega, Alberto, Kaveri, Srinivas V., Coutinho, Antonio, Kazatchkine, Michel D.

The present study demonstrates that natural IgG with anti-endothelial cell activity is present in the serum of healthy individuals and in pooled normal human Ig. By using a novel method that allows...

Human immunoglobulin preparations for intravenous use prevent experimental autoimmune uveoretinitis (1993)

Saoudi, Abdelhadi, Hurez, Vincent, De Kozak, Yvonne, Kuhn, Joelle, Kaveri, Srinivas V., Kazatchkine, Michel D., ...

We have evaluated the effect of human Igs for intravenous use (IVIg) on the onset and development of experimental autoimmune uveoretinitis (EAU), a T cell-dependent autoimmune disease induced in rats...

A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes

Dasgupta, Suryasarathi, Navarrete, Ana-Maria, Bayry, Jagadeesh, Delignat, Sandrine, Wootla, Bharath, André, Sébastien, ...

Several therapeutic self-proteins elicit immune responses when administered to patients. Such adverse immune responses reduce drug efficacy. To induce an immune response, a protein must interact with...

Infection of Macrophages and Dendritic Cells with Primary R5-Tropic Human Immunodeficiency Virus Type 1 Inhibited by Natural Polyreactive Anti-CCR5 Antibodies Purified from Cervicovaginal Secretions▿

Eslahpazir, Jobin, Jenabian, Mohammad-Ali, Bouhlal, Hicham, Hocini, Hakim, Carbonneil, Cédric, Grésenguet, Gérard, ...

Heterosexual contact is the primary mode of human immunodeficiency virus (HIV) type 1 (HIV-1) transmission worldwide. The chemokine receptor CCR5 is the major coreceptor that is associated with the...