Srinivasarao Raghothama

Designed Peptides with Homochiral and Heterochiral Diproline Templates as Conformational Constraints (2008)

Chatterjee, Bhaswati, Saha, Indranil, Raghothama, Srinivasarao, Aravinda, Subrayashastry, Rai, Rajkishor, Shamala, Narayanaswamy, ...

Diproline segments have been advanced as templates for nucleation of folded structure in designed peptides. The conformational space available to homochiral and heterochiral diproline segments has...

Designed Peptides with Homochiral and Heterochiral Diproline Templates as Conformational Constraints (2008)

Chatterjee, Bhaswati, Saha, Indranil, Raghothama, Srinivasarao, Aravinda, Subrayashastry, Rai, Rajkishor, Shamala, Narayanaswamy, ...

Diproline segments have been advanced as templates for nucleation of folded structure in designed peptides. The conformational space available to homochiral and heterochiral diproline segments has...

Tryptophan Rich Peptides: Influence of Indole Rings on Backbone Conformation (2007)

Mahalakshmi, Radhakrishnan, Sengupta, Anindita, Raghothama, Srinivasarao, Shamala, Narayanaswamy, Balaram, Padmanabhan

Synthetic peptides with defined secondary structure scaffolds, namely hairpins and helices, containing tryptophan residues, have been investigated in this study to probe the influence of a large...

Hybrid Peptides: Expanding the \beta Turn in Peptide Hairpins by the Insertion of \beta-, \gamma-, and \delta-Residues (2007)

Rai, Rajkishor, Vasudev, Prema G, Ananda, Kuppanna, Raghothama, Srinivasarao, Shamala, Narayanaswamy, Karle, Isabella L, ...

The \beta turn segment in designed peptide hairpins has been expanded by the insertion of \beta-, \gamma- and \delta amino acids at the i+2 position. The model octapeptides...

Tryptophan Rich Peptides: Influence of Indole Rings on Backbone Conformation (2007)

Mahalakshmi, Radhakrishnan, Sengupta, Anindita, Raghothama, Srinivasarao, Shamala, Narayanaswamy, Balaram, Padmanabhan

Synthetic peptides with defined secondary structure scaffolds, namely hairpins and helices, containing tryptophan residues, have been investigated in this study to probe the influence of a large...

Hybrid Peptides: Expanding the \beta Turn in Peptide Hairpins by the Insertion of \beta-, \gamma-, and \delta-Residues (2007)

Rai, Rajkishor, Vasudev, Prema G, Ananda, Kuppanna, Raghothama, Srinivasarao, Shamala, Narayanaswamy, Karle, Isabella L, ...

The \beta turn segment in designed peptide hairpins has been expanded by the insertion of \beta-, \gamma- and \delta amino acids at the i+2 position. The model octapeptides...

Tuning the $\beta$-Turn Segment in Designed Peptide $\beta$-Hairpins: Construction a Stable Type I' $\beta$-Turn Nucleus and Hairpin-Helix Transition Promoting Segments (2006)

Rai, Rajkishor, Raghothama, Srinivasarao, Sridharan, Rajagopalan, Balaram, Padmanabhan

Designed octapeptides Boc-Leu-Val-Val-Aib-$^DXxx$-Leu-Val-Val-OMe $(^DXxx=^DAla, 3a; ^DVal, 3c$ and $^DPro, 5a)$ and Boc-Leu-Phe-Val-Aib-$^DAla$-Leu-Phe-Val-OMe (3b) have been investigated to...

Design of a Peptide Hairpin Containing a Central Three-Residue Loop (2006)

Rai, Rajkishor, Raghothama, Srinivasarao, Balaram, Padmanabhan

The construction of a designed $\beta$-hairpin structure, containing a central three-residue loop has been successfully achieved in the synthetic nonapeptide...

Design of a Peptide Hairpin Containing a Central Three-Residue Loop (2006)

Rai, Rajkishor, Raghothama, Srinivasarao, Balaram, Padmanabhan

The construction of a designed $\beta$-hairpin structure, containing a central three-residue loop has been successfully achieved in the synthetic nonapeptide...

Tuning the $\beta$-Turn Segment in Designed Peptide $\beta$-Hairpins: Construction a Stable Type I' $\beta$-Turn Nucleus and Hairpin-Helix Transition Promoting Segments (2006)

Rai, Rajkishor, Raghothama, Srinivasarao, Sridharan, Rajagopalan, Balaram, Padmanabhan

Designed octapeptides Boc-Leu-Val-Val-Aib-$^DXxx$-Leu-Val-Val-OMe $(^DXxx=^DAla, 3a; ^DVal, 3c$ and $^DPro, 5a)$ and Boc-Leu-Phe-Val-Aib-$^DAla$-Leu-Phe-Val-OMe (3b) have been investigated to...